Author, as appears in the article.: Gómez-Canela C., Rovira García X., Martínez-Jerónimo F., Marcé R., Barata C.
Department: Química Analítica i Química Orgànica
URV's Author/s: Marcé Recasens, Rosa Maria
Keywords: Serotonin reuptake inhibitors Pharmaceuticals Norepinephrine Neurotransmittors Neurotransmitters Monoamines Metabolites Mechanisms Liquid chromatography-orbitrap-high resolution mass spectrometry Lc-orbitrap Fluoxetine Duloxetine Daphnia magna Brain Behavior Antidepressants neurotransmitters lc-orbitrap daphnia magna
Abstract: Neurotransmission plays an essential role during the central nervous system (CNS) development. During the last years, several studies based on the changes produced in neurotransmitters of aquatic organisms caused by pharmaceuticals have been reported. Daphnia magna, the aquatic ecotoxicological model organism, shares several of the neurotransmitters targeted by antidepressant and other neuro-active drugs with vertebrates. Therefore, a method based on liquid chromatography coupled to high-resolution mass spectrometry (LC-HRMS) has been applied for the first time to study the levels of 41 neurotransmitters in Daphnia magna under the effect of four different neuro-active pharmaceuticals (sertraline, venlafaxine, duloxetine and fluoxetine). In addition, the performance of LC-HRMS was studied in terms of linearity, sensitivity, intra- and inter-day precision, and overall robustness. The developed analytical method using LC-HRMS is a new tool for neurotoxicology research using the Daphnia magna model. As a result, general differences on the concentrations of those neurotransmitters exposed to the mentioned pharmaceuticals were observed.Copyright © 2019 Elsevier Ltd. All rights reserved.
Thematic Areas: Zootecnia / recursos pesqueiros Toxicology Saúde coletiva Química Pollution Nutrição Medicine (miscellaneous) Medicina ii Medicina i Matemática / probabilidade e estatística Interdisciplinar Health, toxicology and mutagenesis Geografía Geociências General medicine Farmacia Environmental sciences Ensino Engenharias iii Engenharias ii Engenharias i Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Arquitetura e urbanismo
ISSN: 02697491
Author's mail: rosamaria.marce@urv.cat
Author identifier: 0000-0002-5667-2899
Record's date: 2023-02-22
Journal volume: 254
Papper version: info:eu-repo/semantics/acceptedVersion
Papper original source: Environmental Pollution. 254 (Pt B): 113029-113029
APA: Gómez-Canela C., Rovira García X., Martínez-Jerónimo F., Marcé R., Barata C. (2019). Analysis of neurotransmitters in Daphnia magna affected by neuroactive pharmaceuticals using liquid chromatography-high resolución mass spectrometry. Environmental Pollution, 254(Pt B), 113029-113029. DOI: 10.1016/j.envpol.2019.113029
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Entity: Universitat Rovira i Virgili
Journal publication year: 2019
First page: Article number 113029
Publication Type: Journal Publications
Repositori URV