Autor según el artículo: Gómez-Canela C., Rovira García X., Martínez-Jerónimo F., Marcé R., Barata C.

Departamento: Química Analítica i Química Orgànica

Autor/es de la URV: Marcé Recasens, Rosa Maria

Palabras clave: Serotonin reuptake inhibitors Pharmaceuticals Norepinephrine Neurotransmittors Neurotransmitters Monoamines Metabolites Mechanisms Liquid chromatography-orbitrap-high resolution mass spectrometry Lc-orbitrap Fluoxetine Duloxetine Daphnia magna Brain Behavior Antidepressants neurotransmitters lc-orbitrap daphnia magna

Resumen: Neurotransmission plays an essential role during the central nervous system (CNS) development. During the last years, several studies based on the changes produced in neurotransmitters of aquatic organisms caused by pharmaceuticals have been reported. Daphnia magna, the aquatic ecotoxicological model organism, shares several of the neurotransmitters targeted by antidepressant and other neuro-active drugs with vertebrates. Therefore, a method based on liquid chromatography coupled to high-resolution mass spectrometry (LC-HRMS) has been applied for the first time to study the levels of 41 neurotransmitters in Daphnia magna under the effect of four different neuro-active pharmaceuticals (sertraline, venlafaxine, duloxetine and fluoxetine). In addition, the performance of LC-HRMS was studied in terms of linearity, sensitivity, intra- and inter-day precision, and overall robustness. The developed analytical method using LC-HRMS is a new tool for neurotoxicology research using the Daphnia magna model. As a result, general differences on the concentrations of those neurotransmitters exposed to the mentioned pharmaceuticals were observed.Copyright © 2019 Elsevier Ltd. All rights reserved.

Áreas temáticas: Zootecnia / recursos pesqueiros Toxicology Saúde coletiva Química Pollution Nutrição Medicine (miscellaneous) Medicina ii Medicina i Matemática / probabilidade e estatística Interdisciplinar Health, toxicology and mutagenesis Geografía Geociências General medicine Farmacia Environmental sciences Ensino Engenharias iii Engenharias ii Engenharias i Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Arquitetura e urbanismo

ISSN: 02697491

Direcció de correo del autor: rosamaria.marce@urv.cat

Identificador del autor: 0000-0002-5667-2899

Fecha de alta del registro: 2023-02-22

Volumen de revista: 254

Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion

Enlace a la fuente original: https://www.sciencedirect.com/science/article/abs/pii/S0269749119319220

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Environmental Pollution. 254 (Pt B): 113029-113029

Referencia de l'ítem segons les normes APA: Gómez-Canela C., Rovira García X., Martínez-Jerónimo F., Marcé R., Barata C. (2019). Analysis of neurotransmitters in Daphnia magna affected by neuroactive pharmaceuticals using liquid chromatography-high resolución mass spectrometry. Environmental Pollution, 254(Pt B), 113029-113029. DOI: 10.1016/j.envpol.2019.113029

DOI del artículo: 10.1016/j.envpol.2019.113029

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2019

Página inicial: Article number 113029

Tipo de publicación: Journal Publications