Author, as appears in the article.: Girona, Josefa; Rodriguez-Borjabad, Celia; Ibarretxe, Daiana; Vallve, Joan-Carles; Ferre, Raimon; Heras, Mercedes; Rodriguez-Calvo, Ricardo; Guaita-Esteruelas, Sandra; Martinez-Micaelo, Neus; Plana, Nuria; Masana, Lluis
Department: Ciències Mèdiques Bàsiques Medicina i Cirurgia
e-ISSN: 2077-0383
URV's Author/s: FERRÉ VALLÈS, RAIMON / Girona Tell, Josefa / GUAITA ESTERUELAS, SANDRA / HERAS IBAÑEZ, MERCEDES / Ibarretxe Gerediaga, Daiana / Masana Marín, Luis / Plana Gil, Núria / Rodríguez Borjabad, Cèlia / Vallvé Torrente, Joan Carles
Keywords: Type 2 diabetes Resistance Obesity Obese Metabolic syndrome Media thickness Mechanism Insulin Induction Homeostasis Grp78/bip Fenofibrate/niacin treatment Fenofibrate Er stress Endoplasmic reticulum stress Cholesterol Carotid intima–media thickness Carotid intima-media thickness Carotid intima Cardiovascular risk Atherosclerosis Adipose-tissue obesity metabolic syndrome grp78/bip fenofibrate/niacin treatment endoplasmic reticulum stress carotid intima–media thickness cardiovascular risk atherosclerosis
Abstract: Background: Glucose-regulated protein 78/Binding immunoglobulin protein (GRP78/BiP) is a protein associated with endoplasmic reticulum stress and is upregulated by metabolic alterations at the tissue-level, such as hypoxia or glucose deprivation, and it is hyper-expressed in fat tissue of obese individuals. Objective: To investigate the role of the GRP78/BiP level as a metabolic and vascular disease biomarker in patients with type 2 diabetes (DM), obesity and metabolic syndrome (MS). Methods: Four hundred and five patients were recruited, of whom 52.5% were obese, 72.8% had DM, and 78.6% had MS. The intimae media thickness (cIMT) was assessed by ultrasonography. The plasma GRP78/BiP concentration was determined, and its association with metabolic and vascular parameters was assessed. Circulating GRP78/BiP was also prospectively measured in 30 DM patients before and after fenofibrate/niacin treatment and 30 healthy controls. Results: In the cross-sectional study, the GRP78/BiP level was significantly higher in the patients with obesity, DM, and MS. Age-, gender- and BMI-adjusted GRP78/BiP was directly associated with LDL-cholesterol, non-HDL-cholesterol, triglycerides, apoB, and cIMT. GRP78/BiP was positively associated to carotid plaque presence in the adjusted model, irrespective of obesity, DM and MS. In the prospective study, nicotinic acid treatment produced a significant reduction in the GRP78/BiP levels that was not observed with fenofibrate. Conclusions: GRP78/BiP plasma concentrations are increased in patients with both metabolic derangements and subclinical atherosclerosis. GRP78/BiP could be a useful marker of metabolic and cardiovascular risk.
Thematic Areas: Medicine, general & internal Medicine (miscellaneous) Medicine (all)
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 20770383
Author's mail: celia.rodriguez@urv.cat daiana.ibarretxe@urv.cat josefa.girona@urv.cat jc.vallve@urv.cat celia.rodriguez@urv.cat josefa.girona@urv.cat jc.vallve@urv.cat luis.masana@urv.cat
Author identifier: 0000-0001-8160-3716 0000-0002-6267-8779 0000-0001-8160-3716 0000-0002-6267-8779 0000-0002-0789-4954
Record's date: 2024-09-28
Journal volume: 8
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.mdpi.com/2077-0383/8/11/1793
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Journal Of Clinical Medicine. 8 (11): 1793-
APA: Girona, Josefa; Rodriguez-Borjabad, Celia; Ibarretxe, Daiana; Vallve, Joan-Carles; Ferre, Raimon; Heras, Mercedes; Rodriguez-Calvo, Ricardo; Guaita-Es (2019). The Circulating GRP78/BiP Is a Marker of Metabolic Diseases and Atherosclerosis: Bringing Endoplasmic Reticulum Stress into the Clinical Scenario. Journal Of Clinical Medicine, 8(11), 1793-. DOI: 10.3390/jcm8111793
Article's DOI: 10.3390/jcm8111793
Entity: Universitat Rovira i Virgili
Journal publication year: 2019
Publication Type: Journal Publications