Author, as appears in the article.: Gonzalez-Quilen, Carlos; Rodriguez-Gallego, Esther; Beltran-Debon, Raul; Pinent, Montserrat; Ardevol, Anna; Teresa Blay, M; Terra, Ximena
Department: Bioquímica i Biotecnologia
URV's Author/s: Ardévol Grau, Anna / Beltrán Debón, Raúl Alejandro / Blay Olivé, Maria Teresa / GONZALEZ QUILEN, CARLOS ALBERTO / Pinent Armengol, Montserrat / Rodríguez Gallego, Esther / Terra Barbadora, Ximena
Keywords: Ulcerative-colitis; Signal-transduction pathways; Procyanidin; Proanthocyanidins; Phytochemicals; Permeability; Oxidative stress; Obesity; Nf-kappa-b; Metabolic endotoxemia; Inflammatory-bowel-disease; Inflammatory bowel diseases; Inflammation; In-vitro; Ibd; Humans; Gut microbiota; Gut; Grape seed extract; Food sources; Flavonoid; Flavan-3-ol; Dietary polyphenols; Condensed tannin; Animals; permeability; obesity; metabolic endotoxemia; inflammation; ibd; gut; flavonoid; flavan-3-ol; condensed tannin
Abstract: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. The intestinal barrier is constantly exposed to potentially harmful environmental factors, including food components and bacterial endotoxins. When intestinal barrier function and immune homeostasis are compromised (intestinal dysfunction), inflammatory conditions may develop and impact overall health. Evidence from experimental animal and cell culture studies suggests that exposure of intestinal mucosa to proanthocyanidin (PAC)-rich plant products, such as grape seeds, may contribute to maintaining the barrier function and to ameliorating the pathological inflammation present in diet-induced obesity and inflammatory bowel disease. In this review, we aim to update the current knowledge on the bioactivity of PACs in experimental models of intestinal dysfunction and in humans, and to provide insights into the underlying biochemical and molecular mechanisms.
Thematic Areas: Zootecnia / recursos pesqueiros; Saúde coletiva; Química; Psicología; Planejamento urbano e regional / demografia; Nutrition and dietetics; Nutrition & dietetics; Nutrição; Medicina veterinaria; Medicina iii; Medicina ii; Medicina i; Interdisciplinar; Food science; Farmacia; Engenharias iv; Engenharias ii; Enfermagem; Educação física; Economia; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Ciências agrárias i; Ciência de alimentos; Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 20726643
Author's mail: anna.ardevol@urv.cat; ximena.terra@urv.cat; mteresa.blay@urv.cat; esther.rodriguez@urv.cat; montserrat.pinent@urv.cat; raul.beltran@urv.cat
Record's date: 2024-10-19
Journal volume: 12
Paper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.mdpi.com/2072-6643/12/1/130
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Paper original source: Nutrients. 12 (1): E130-
APA: Gonzalez-Quilen, Carlos; Rodriguez-Gallego, Esther; Beltran-Debon, Raul; Pinent, Montserrat; Ardevol, Anna; Teresa Blay, M; Terra, Ximena (2020). Health-promoting properties of proanthocyanidins for intestinal dysfunction. Nutrients, 12(1), E130-. DOI: 10.3390/nu12010130
Article's DOI: 10.3390/nu12010130
Entity: Universitat Rovira i Virgili
Journal publication year: 2020
Publication Type: Journal Publications
Repositori URV