Author, as appears in the article.: González-Quilen C; Rodríguez-Gallego E; Beltrán-Debón R; Pinent M; Ardévol A; Blay M; Terra X
Department: Bioquímica i Biotecnologia
URV's Author/s: Ardévol Grau, Anna / Beltrán Debón, Raúl Alejandro / Blay Olivé, Maria Teresa / GONZALEZ QUILEN, CARLOS ALBERTO / Pinent Armengol, Montserrat / Rodríguez Gallego, Esther / Terra Barbadora, Ximena
Keywords: Ulcerative-colitis Signal-transduction pathways Procyanidin Permeability Oxidative stress Obesity Nf-kappa-b Metabolic endotoxemia Inflammatory-bowel-disease Inflammation In-vitro Ibd Gut microbiota Gut Grape seed extract Food sources Flavonoid Flavan-3-ol Dietary polyphenols Condensed tannin permeability obesity metabolic endotoxemia inflammation ibd gut flavonoid flavan-3-ol condensed tannin
Abstract: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. The intestinal barrier is constantly exposed to potentially harmful environmental factors, including food components and bacterial endotoxins. When intestinal barrier function and immune homeostasis are compromised (intestinal dysfunction), inflammatory conditions may develop and impact overall health. Evidence from experimental animal and cell culture studies suggests that exposure of intestinal mucosa to proanthocyanidin (PAC)-rich plant products, such as grape seeds, may contribute to maintaining the barrier function and to ameliorating the pathological inflammation present in diet-induced obesity and inflammatory bowel disease. In this review, we aim to update the current knowledge on the bioactivity of PACs in experimental models of intestinal dysfunction and in humans, and to provide insights into the underlying biochemical and molecular mechanisms.
Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 20726643
Author's mail: raul.beltran@urv.cat montserrat.pinent@urv.cat esther.rodriguez@urv.cat mteresa.blay@urv.cat ximena.terra@urv.cat anna.ardevol@urv.cat
Author identifier: 0000-0001-9691-1906 0000-0003-3550-5378 0000-0002-6256-9847 0000-0003-1043-5844 0000-0003-0156-7538
Record's date: 2024-06-22
Journal volume: 12
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.mdpi.com/2072-6643/12/1/130
Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Nutrients. 12 (1):
APA: González-Quilen C; Rodríguez-Gallego E; Beltrán-Debón R; Pinent M; Ardévol A; Blay M; Terra X (2020). Health-promoting properties of proanthocyanidins for intestinal dysfunction. Nutrients, 12(1), -. DOI: 10.3390/nu12010130
Article's DOI: 10.3390/nu12010130
Entity: Universitat Rovira i Virgili
Journal publication year: 2020
Publication Type: Journal Publications
Repositori URV