Author, as appears in the article.: Gonzalez-Quilen, Carlos; Rodriguez-Gallego, Esther; Beltran-Debon, Raul; Pinent, Montserrat; Ardevol, Anna; Teresa Blay, M; Terra, Ximena
Department: Bioquímica i Biotecnologia
URV's Author/s: Ardévol Grau, Anna / Beltrán Debón, Raúl Alejandro / Blay Olivé, Maria Teresa / GONZALEZ QUILEN, CARLOS ALBERTO / Pinent Armengol, Montserrat / Rodríguez Gallego, Esther / Terra Barbadora, Ximena
Keywords: Ulcerative-colitis Signal-transduction pathways Procyanidin Proanthocyanidins Phytochemicals Permeability Oxidative stress Obesity Nf-kappa-b Metabolic endotoxemia Inflammatory-bowel-disease Inflammatory bowel diseases Inflammation In-vitro Ibd Humans Gut microbiota Gut Grape seed extract Food sources Flavonoid Flavan-3-ol Dietary polyphenols Condensed tannin Animals permeability obesity metabolic endotoxemia inflammation ibd gut flavonoid flavan-3-ol condensed tannin
Abstract: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. The intestinal barrier is constantly exposed to potentially harmful environmental factors, including food components and bacterial endotoxins. When intestinal barrier function and immune homeostasis are compromised (intestinal dysfunction), inflammatory conditions may develop and impact overall health. Evidence from experimental animal and cell culture studies suggests that exposure of intestinal mucosa to proanthocyanidin (PAC)-rich plant products, such as grape seeds, may contribute to maintaining the barrier function and to ameliorating the pathological inflammation present in diet-induced obesity and inflammatory bowel disease. In this review, we aim to update the current knowledge on the bioactivity of PACs in experimental models of intestinal dysfunction and in humans, and to provide insights into the underlying biochemical and molecular mechanisms.
Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 20726643
Author's mail: anna.ardevol@urv.cat ximena.terra@urv.cat mteresa.blay@urv.cat esther.rodriguez@urv.cat montserrat.pinent@urv.cat raul.beltran@urv.cat
Author identifier: 0000-0003-0156-7538 0000-0003-1043-5844 0000-0002-6256-9847 0000-0003-3550-5378 0000-0001-9691-1906
Record's date: 2024-10-19
Journal volume: 12
Papper version: info:eu-repo/semantics/publishedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Nutrients. 12 (1): E130-
APA: Gonzalez-Quilen, Carlos; Rodriguez-Gallego, Esther; Beltran-Debon, Raul; Pinent, Montserrat; Ardevol, Anna; Teresa Blay, M; Terra, Ximena (2020). Health-promoting properties of proanthocyanidins for intestinal dysfunction. Nutrients, 12(1), E130-. DOI: 10.3390/nu12010130
Entity: Universitat Rovira i Virgili
Journal publication year: 2020
Publication Type: Journal Publications
Repositori URV