Articles producció científica> Bioquímica i Biotecnologia

New Eunicellin-Type Diterpenes from the Panamanian Octocoral Briareum Asbestinum

  • Identification data

    Identifier: imarina:6112075
    Authors:
    Gutiérrez MSantamaría RGómez-Reyes JFGuzmán HMÁvila-Román JMotilva VTalero E
    Abstract:
    Gorgonian octocorals are considered a prolific source of secondary metabolites with a wide range of biological activities, including anti-inflammatory activity. In particular, the genus Briareum is known for producing a wealth of diterpenes with complex chemical structures. The chemical study of the methanolic extract of Briareum asbestinum collected in Bocas del Toro, on the Caribbean side of Panama, led to the isolation of three new eunicellin-type diterpenes: briarellin T (1), asbestinin 27 (2), asbestinin 28 (3) and the previously described asbestinin 17 (4). The structures of the new compounds were determined by extensive NMR analyses and HRMS. Anti-inflammatory activity assays showed a significant reduction of the pro-inflammatory cytokines TNF-α, IL-6, IL-1β and IL-8 as well as a downregulation of COX-2 expression in LPS-stimulated THP-1 macrophages. These findings support the potential use of these marine compounds as therapeutic agents in the treatment of inflammatory diseases.
  • Others:

    Author, as appears in the article.: Gutiérrez M; Santamaría R; Gómez-Reyes JF; Guzmán HM; Ávila-Román J; Motilva V; Talero E
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Ávila Román, Francisco Javier
    Keywords: Natural-products Microalgae Inflammation Gorgonian corals Eunicellin diterpenes Cytokines Cyclooxygenase-2 Chemistry Briareum Briarellins Asbestinins cytokines cyclooxygenase-2 briareum briarellins asbestinins
    Abstract: Gorgonian octocorals are considered a prolific source of secondary metabolites with a wide range of biological activities, including anti-inflammatory activity. In particular, the genus Briareum is known for producing a wealth of diterpenes with complex chemical structures. The chemical study of the methanolic extract of Briareum asbestinum collected in Bocas del Toro, on the Caribbean side of Panama, led to the isolation of three new eunicellin-type diterpenes: briarellin T (1), asbestinin 27 (2), asbestinin 28 (3) and the previously described asbestinin 17 (4). The structures of the new compounds were determined by extensive NMR analyses and HRMS. Anti-inflammatory activity assays showed a significant reduction of the pro-inflammatory cytokines TNF-α, IL-6, IL-1β and IL-8 as well as a downregulation of COX-2 expression in LPS-stimulated THP-1 macrophages. These findings support the potential use of these marine compounds as therapeutic agents in the treatment of inflammatory diseases.
    Thematic Areas: Zootecnia / recursos pesqueiros Química Pharmacology, toxicology and pharmaceutics (miscellaneous) Pharmacology & pharmacy Pharmaceutical science Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Geociências Farmacia Engenharias iii Engenharias ii Educação física Drug discovery Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Chemistry, medicinal Biotecnología Biodiversidade Astronomia / física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 1660-3397
    Author's mail: franciscojavier.avila@urv.cat
    Author identifier: 0000-0001-9766-8178
    Record's date: 2023-02-19
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.mdpi.com/1660-3397/18/2/84
    Papper original source: Marine Drugs. 18 (2):
    APA: Gutiérrez M; Santamaría R; Gómez-Reyes JF; Guzmán HM; Ávila-Román J; Motilva V; Talero E (2020). New Eunicellin-Type Diterpenes from the Panamanian Octocoral Briareum Asbestinum. Marine Drugs, 18(2), -. DOI: 10.3390/md18020084
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Article's DOI: 10.3390/md18020084
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2020
    Publication Type: Journal Publications
  • Keywords:

    Chemistry, Medicinal,Drug Discovery,Pharmaceutical Science,Pharmacology & Pharmacy,Pharmacology, Toxicology and Pharmaceutics (Miscellaneous)
    Natural-products
    Microalgae
    Inflammation
    Gorgonian corals
    Eunicellin diterpenes
    Cytokines
    Cyclooxygenase-2
    Chemistry
    Briareum
    Briarellins
    Asbestinins
    cytokines
    cyclooxygenase-2
    briareum
    briarellins
    asbestinins
    Zootecnia / recursos pesqueiros
    Química
    Pharmacology, toxicology and pharmaceutics (miscellaneous)
    Pharmacology & pharmacy
    Pharmaceutical science
    Nutrição
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Geociências
    Farmacia
    Engenharias iii
    Engenharias ii
    Educação física
    Drug discovery
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Chemistry, medicinal
    Biotecnología
    Biodiversidade
    Astronomia / física
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