Autor según el artículo: Gutiérrez M; Santamaría R; Gómez-Reyes JF; Guzmán HM; Ávila-Román J; Motilva V; Talero E

Departamento: Bioquímica i Biotecnologia

Autor/es de la URV: Ávila Román, Francisco Javier

Palabras clave: Natural-products Microalgae Inflammation Gorgonian corals Eunicellin diterpenes Cytokines Cyclooxygenase-2 Chemistry Briareum Briarellins Asbestinins cytokines cyclooxygenase-2 briareum briarellins asbestinins

Resumen: Gorgonian octocorals are considered a prolific source of secondary metabolites with a wide range of biological activities, including anti-inflammatory activity. In particular, the genus Briareum is known for producing a wealth of diterpenes with complex chemical structures. The chemical study of the methanolic extract of Briareum asbestinum collected in Bocas del Toro, on the Caribbean side of Panama, led to the isolation of three new eunicellin-type diterpenes: briarellin T (1), asbestinin 27 (2), asbestinin 28 (3) and the previously described asbestinin 17 (4). The structures of the new compounds were determined by extensive NMR analyses and HRMS. Anti-inflammatory activity assays showed a significant reduction of the pro-inflammatory cytokines TNF-α, IL-6, IL-1β and IL-8 as well as a downregulation of COX-2 expression in LPS-stimulated THP-1 macrophages. These findings support the potential use of these marine compounds as therapeutic agents in the treatment of inflammatory diseases.

Áreas temáticas: Zootecnia / recursos pesqueiros Química Pharmacology, toxicology and pharmaceutics (miscellaneous) Pharmacology & pharmacy Pharmaceutical science Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Geociências Farmacia Engenharias iii Engenharias ii Educação física Drug discovery Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Chemistry, medicinal Biotecnología Biodiversidade Astronomia / física

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 1660-3397

Direcció de correo del autor: franciscojavier.avila@urv.cat

Identificador del autor: 0000-0001-9766-8178

Fecha de alta del registro: 2023-02-19

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Enlace a la fuente original: https://www.mdpi.com/1660-3397/18/2/84

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Marine Drugs. 18 (2):

Referencia de l'ítem segons les normes APA: Gutiérrez M; Santamaría R; Gómez-Reyes JF; Guzmán HM; Ávila-Román J; Motilva V; Talero E (2020). New Eunicellin-Type Diterpenes from the Panamanian Octocoral Briareum Asbestinum. Marine Drugs, 18(2), -. DOI: 10.3390/md18020084

DOI del artículo: 10.3390/md18020084

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2020

Tipo de publicación: Journal Publications