Articles producció científica> Enginyeria Electrònica, Elèctrica i Automàtica

Lifestyle Intervention Decreases Urine Trimethylamine N-Oxide Levels in Prepubertal Children with Obesity

  • Identification data

    Identifier: imarina:6178125
    Authors:
    Leal-Witt, Maria JLlobet, MarinaSamino, SaraCastellano, PolCuadras, DanielJimenez-Chillaron, Josep CYanes, OscarRamon-Krauel, MartaLerin, Carles
    Abstract:
    Objective: Early lifestyle interventions in children with obesity decrease risk of obesity and metabolic disorders during adulthood. This study aimed to identify metabolic signatures associated with lifestyle intervention in urine samples from prepubertal children with obesity. Methods: Thirty-four prepubertal children with obesity were studied before and after a 6-month lifestyle intervention program, and anthropometric, metabolic, and nutritional variables were collected. A nuclear magnetic resonance approach was applied to obtain the metabolomic profile from urine samples. Partial least squares-discriminant analysis (PLS-DA) was used to achieve group classification and variable importance on projection (VIP) for biomarker selection. Results: The intervention reduced caloric intake by 10% (P<0.05) and BMI standard deviation score by 0.47 SD (P<0.001). PLS-DA identified trimethylamine N-oxide (TMAO, VIP=2.21) as the metabolite with the highest discrimination properties between groups. Urine TMAO levels were reduced after the intervention (P<0.05). TMAO is a biomarker of cardiovascular disease risk and is a product of gut microbiota-dependent metabolism of certain dietary compounds, including choline. Notably, changes in TMAO levels after the intervention did not correlate to differences in choline intake but were inversely associated with fiber intake (P<0.05). Conclusions: These results indicate that lifestyle intervention decreases TMAO levels in children with obesity.
  • Others:

    Author, as appears in the article.: Leal-Witt, Maria J; Llobet, Marina; Samino, Sara; Castellano, Pol; Cuadras, Daniel; Jimenez-Chillaron, Josep C; Yanes, Oscar; Ramon-Krauel, Marta; Lerin, Carles
    Department: Enginyeria Electrònica, Elèctrica i Automàtica
    URV's Author/s: SAMINO GENÉ, SARA / Yanes Torrado, Óscar
    Keywords: Risk Phosphatidylcholine Overweight Metabolomics Metabolism Intestinal microbiota Impact Heart Childhood obesity Adulthood
    Abstract: Objective: Early lifestyle interventions in children with obesity decrease risk of obesity and metabolic disorders during adulthood. This study aimed to identify metabolic signatures associated with lifestyle intervention in urine samples from prepubertal children with obesity. Methods: Thirty-four prepubertal children with obesity were studied before and after a 6-month lifestyle intervention program, and anthropometric, metabolic, and nutritional variables were collected. A nuclear magnetic resonance approach was applied to obtain the metabolomic profile from urine samples. Partial least squares-discriminant analysis (PLS-DA) was used to achieve group classification and variable importance on projection (VIP) for biomarker selection. Results: The intervention reduced caloric intake by 10% (P<0.05) and BMI standard deviation score by 0.47 SD (P<0.001). PLS-DA identified trimethylamine N-oxide (TMAO, VIP=2.21) as the metabolite with the highest discrimination properties between groups. Urine TMAO levels were reduced after the intervention (P<0.05). TMAO is a biomarker of cardiovascular disease risk and is a product of gut microbiota-dependent metabolism of certain dietary compounds, including choline. Notably, changes in TMAO levels after the intervention did not correlate to differences in choline intake but were inversely associated with fiber intake (P<0.05). Conclusions: These results indicate that lifestyle intervention decreases TMAO levels in children with obesity.
    Thematic Areas: Saúde coletiva Psicología Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Enfermagem Endocrinology, diabetes and metabolism Endocrinology & metabolism Endocrinology Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciência de alimentos Biotecnología
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 19307381
    Author's mail: oscar.yanes@urv.cat
    Author identifier: 0000-0003-3695-7157
    Record's date: 2024-10-12
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://onlinelibrary.wiley.com/doi/full/10.1002/oby.22271
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Obesity. 26 (10): 1603-1610
    APA: Leal-Witt, Maria J; Llobet, Marina; Samino, Sara; Castellano, Pol; Cuadras, Daniel; Jimenez-Chillaron, Josep C; Yanes, Oscar; Ramon-Krauel, Marta; Ler (2018). Lifestyle Intervention Decreases Urine Trimethylamine N-Oxide Levels in Prepubertal Children with Obesity. Obesity, 26(10), 1603-1610. DOI: 10.1002/oby.22271
    Article's DOI: 10.1002/oby.22271
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2018
    Publication Type: Journal Publications
  • Keywords:

    Endocrinology,Endocrinology & Metabolism,Endocrinology, Diabetes and Metabolism,Medicine (Miscellaneous),Nutrition & Dietetics,Nutrition and Dietetics
    Risk
    Phosphatidylcholine
    Overweight
    Metabolomics
    Metabolism
    Intestinal microbiota
    Impact
    Heart
    Childhood obesity
    Adulthood
    Saúde coletiva
    Psicología
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicine (miscellaneous)
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    General medicine
    Farmacia
    Enfermagem
    Endocrinology, diabetes and metabolism
    Endocrinology & metabolism
    Endocrinology
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciência de alimentos
    Biotecnología
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