Author, as appears in the article.: Dasilva G; Pazos M; García-Egido E; Pérez-Jiménez J; Torres J; Giralt M; Nogués M; Medina I
Department: Ciències Mèdiques Bàsiques
URV's Author/s: Giralt Batista, Montserrat / Nogués Llort, Maria Rosa
Keywords: Shrob Oxidative stress Metabolism Metabolic syndrome Lipid mediators Inflammation Fatty acids Epa Dha Biomarkers oxidative stress metabolic syndrome lipid mediators inflammation epa dha
Abstract: © 2016 Elsevier Ltd. All rights reserved. The role of specific proportions of ω-3 EPA and DHA, in the modulation of inflammation and oxidative stress markers associated to the progression of Metabolic Syndrome was investigated. Potential inflammatory eicosanoids and docosanoids were discussed together to biomarkers of CVD, obesity, inflammation and oxidative stress in an animal model of metabolic disorders. Results evidenced a noteworthy health effect of 1:1 and 2:1 EPA:DHA proportions over 1:2 EPA:DHA based diets through a down-regulation in the production of strong pro-inflammatory ω-6 eicosanoids, a decrement of biomarkers of oxidative stress, and a modulation of fatty acid desaturase activities and plasma and membrane PUFAs towards greater anti-inflammatory profiles. Outcomes contribute to the general knowledge on the health benefits of marine lipids and their role on the progress of MetS, inflammation and oxidative stress. Results shed light on controversial protective mechanisms of EPA and DHA to better design dietary interventions aimed at reducing MetS.
Research group: Farmacobiologia Cel.lular
Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Odontología Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Interdisciplinar Geociências Food science & technology Food science Farmacia Ensino Engenharias iv Engenharias iii Engenharias ii Engenharias i Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Chemistry, applied Biotecnología Biodiversidade Astronomia / física Analytical chemistry Administração pública e de empresas, ciências contábeis e turismo
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 03088146
Author's mail: montse.giralt@urv.cat
Author identifier: 0000-0002-7073-577X
Record's date: 2024-09-07
Papper version: info:eu-repo/semantics/acceptedVersion
Link to the original source: https://www.sciencedirect.com/science/article/abs/pii/S0308814616303715?via%3Dihub
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Food Chemistry. 205 196-203
APA: Dasilva G; Pazos M; García-Egido E; Pérez-Jiménez J; Torres J; Giralt M; Nogués M; Medina I (2016). Lipidomics to analyze the influence of diets with different EPA:DHA ratios in the progression of Metabolic Syndrome using SHROB rats as a model. Food Chemistry, 205(), 196-203. DOI: 10.1016/j.foodchem.2016.03.020
Article's DOI: 10.1016/j.foodchem.2016.03.020
Entity: Universitat Rovira i Virgili
Journal publication year: 2016
Publication Type: Journal Publications
Repositori URV