Author, as appears in the article.: Pastor-Cavada, Elena; Pardo, Leticia M; Kandil, Dalia; Torres-Fuentes, Cristina; Clarke, Sarah L; Shaban, Hamdy; McGlacken, Gerard P; Schellekens, Harriet
Department: Bioquímica i Biotecnologia
URV's Author/s: Torres Fuentes, Cristina
Keywords: Zero hunger
Abstract: © The Author(s) 2016. Loss of appetite in the medically ill and ageing populations is a major health problem and a significant symptom in cachexia syndromes, which is the loss of muscle and fat mass. Ghrelin is a gut-derived hormone which can stimulate appetite. Herein we describe a novel, simple, non-peptidic, 2-pyridone which acts as a selective agonist for the ghrelin receptor (GHS-R1a). The small 2-pyridone demonstrated clear agonistic activity in both transfected human cells and mouse hypothalamic cells with endogenous GHS-R1a receptor expression. In vivo tests with the hit compound showed significant increased food intake following peripheral administration, which highlights the potent orexigenic effect of this novel GHS-R1a receptor ligand.
Thematic Areas: Zootecnia / recursos pesqueiros; Saúde coletiva; Química; Psicología; Odontología; Nutrição; Multidisciplinary sciences; Multidisciplinary; Medicina veterinaria; Medicina iii; Medicina ii; Medicina i; Materiais; Matemática / probabilidade e estatística; Letras / linguística; Interdisciplinar; Geografía; Geociências; Farmacia; Engenharias iv; Engenharias iii; Engenharias ii; Enfermagem; Educação física; Educação; Economia; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Ciências ambientais; Ciências agrárias i; Ciência de alimentos; Ciência da computação; Biotecnología; Biodiversidade; Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 20452322
Author's mail: cristina.torres@urv.cat
Record's date: 2025-02-24
Paper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.nature.com/articles/srep36456
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Paper original source: Scientific Reports. 6 (1): 36456-
APA: Pastor-Cavada, Elena; Pardo, Leticia M; Kandil, Dalia; Torres-Fuentes, Cristina; Clarke, Sarah L; Shaban, Hamdy; McGlacken, Gerard P; Schellekens, Har (2016). A Novel Non-Peptidic Agonist of the Ghrelin Receptor with Orexigenic Activity in vivo. Scientific Reports, 6(1), 36456-. DOI: 10.1038/srep36456
Article's DOI: 10.1038/srep36456
Entity: Universitat Rovira i Virgili
Journal publication year: 2016
Publication Type: Journal Publications
Repositori URV