Author, as appears in the article.: Pastor-Cavada, E; Pardo, LM; Kandil, D; Torres-Fuentes, C; Clarke, SL; Shaban, H; McGlacken, GP; Schellekens, H
Department: Bioquímica i Biotecnologia
URV's Author/s: Torres Fuentes, Cristina
Abstract: © The Author(s) 2016. Loss of appetite in the medically ill and ageing populations is a major health problem and a significant symptom in cachexia syndromes, which is the loss of muscle and fat mass. Ghrelin is a gut-derived hormone which can stimulate appetite. Herein we describe a novel, simple, non-peptidic, 2-pyridone which acts as a selective agonist for the ghrelin receptor (GHS-R1a). The small 2-pyridone demonstrated clear agonistic activity in both transfected human cells and mouse hypothalamic cells with endogenous GHS-R1a receptor expression. In vivo tests with the hit compound showed significant increased food intake following peripheral administration, which highlights the potent orexigenic effect of this novel GHS-R1a receptor ligand.
Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Odontología Nutrição Multidisciplinary sciences Multidisciplinary Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Letras / linguística Interdisciplinar Geografía Geociências Farmacia Engenharias iv Engenharias iii Engenharias ii Enfermagem Educação física Educação Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Biotecnología Biodiversidade Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 20452322
Author's mail: cristina.torres@urv.cat
Author identifier: 0000-0002-2917-6910
Record's date: 2024-02-11
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.nature.com/articles/srep36456
Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Scientific Reports. 6 36456-
APA: Pastor-Cavada, E; Pardo, LM; Kandil, D; Torres-Fuentes, C; Clarke, SL; Shaban, H; McGlacken, GP; Schellekens, H (2016). A Novel Non-Peptidic Agonist of the Ghrelin Receptor with Orexigenic Activity in vivo. Scientific Reports, 6(), 36456-. DOI: 10.1038/srep36456
Article's DOI: 10.1038/srep36456
Entity: Universitat Rovira i Virgili
Journal publication year: 2016
Publication Type: Journal Publications
Repositori URV