Articles producció científica> Bioquímica i Biotecnologia

Effects of flavanols on enteroendocrine secretion

  • Identification data

    Identifier: imarina:6406113
    Authors:
    Grau-Bove, CarmeGonzalez-Quilen, CarlosTerra, XimenaBlay, M TeresaBeltran-Debon, RaulJorba-Martin, RosaEspina, BeatrizPinent, MontserratArdevol, Anna
    Abstract:
    © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Some beneficial effects of grape seed proanthocyanidin extract (GSPE) can be explained by the modulation of enterohormone secretion. As GSPE comprises a combination of different molecules, the pure compounds that cause these effects need to be elucidated. The enterohormones and chemoreceptors present in the gastrointestinal tract differ between species, so if humans are to gain beneficial effects, species closer to humans—and humans themselves—must be used. We demonstrate that 100 mg/L of GSPE stimulates peptide YY (PYY) release, but not glucagon-like peptide 1 (GLP-1) release in the human colon. We used a pig ex vivo system that differentiates between apical and basolateral intestinal sides to analyse how apical stimulation with GSPE and its pure compounds affects the gastrointestinal tract. In pigs, apical GSPE treatment stimulates the basolateral release of PYY in the duodenum and colon and that of GLP-1 in the ascending, but not the descending colon. In the duodenum, luminal stimulation with procyanidin dimer B2 increased PYY secretion, but not CCK secretion, while catechin monomers (catechin/epicatechin) significantly increased CCK release, but not PYY release. The differential effects of GSPE and its pure compounds on enterohormone release at the same intestinal segment suggest that they act through chemosensors located apically and unevenly distributed along the gastrointestinal tract.
  • Others:

    Author, as appears in the article.: Grau-Bove, Carme; Gonzalez-Quilen, Carlos; Terra, Ximena; Blay, M Teresa; Beltran-Debon, Raul; Jorba-Martin, Rosa; Espina, Beatriz; Pinent, Montserrat; Ardevol, Anna
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Ardévol Grau, Anna / Beltrán Debón, Raúl Alejandro / Blay Olivé, Maria Teresa / GONZALEZ QUILEN, CARLOS ALBERTO / Jorba Martin, Rosa Maria / Pinent Armengol, Montserrat / Terra Barbadora, Ximena
    Keywords: Vitis Swine Seeds Pyy Procyanidins Proanthocyanidins Proanthocyanidin Plant extracts Pig Peptide yy Metabolism Intestine Humans Gut hormones Grape seed extract Glucagon-like peptide-1 Glucagon-like peptide 1 Glp-1 Ghrelin production Gastrointestinal tract Flavonoids Cholecystokinin Cells Cck Bitter Animals Absorption pyy glp-1 flavonoids cck
    Abstract: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Some beneficial effects of grape seed proanthocyanidin extract (GSPE) can be explained by the modulation of enterohormone secretion. As GSPE comprises a combination of different molecules, the pure compounds that cause these effects need to be elucidated. The enterohormones and chemoreceptors present in the gastrointestinal tract differ between species, so if humans are to gain beneficial effects, species closer to humans—and humans themselves—must be used. We demonstrate that 100 mg/L of GSPE stimulates peptide YY (PYY) release, but not glucagon-like peptide 1 (GLP-1) release in the human colon. We used a pig ex vivo system that differentiates between apical and basolateral intestinal sides to analyse how apical stimulation with GSPE and its pure compounds affects the gastrointestinal tract. In pigs, apical GSPE treatment stimulates the basolateral release of PYY in the duodenum and colon and that of GLP-1 in the ascending, but not the descending colon. In the duodenum, luminal stimulation with procyanidin dimer B2 increased PYY secretion, but not CCK secretion, while catechin monomers (catechin/epicatechin) significantly increased CCK release, but not PYY release. The differential effects of GSPE and its pure compounds on enterohormone release at the same intestinal segment suggest that they act through chemosensors located apically and unevenly distributed along the gastrointestinal tract.
    Thematic Areas: Química Molecular biology Materiais General medicine Farmacia Ensino Biochemistry & molecular biology Biochemistry
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 2218273X
    Author's mail: anna.ardevol@urv.cat ximena.terra@urv.cat mteresa.blay@urv.cat montserrat.pinent@urv.cat rosamaria.jorba@urv.cat raul.beltran@urv.cat
    Author identifier: 0000-0003-0156-7538 0000-0003-1043-5844 0000-0002-6256-9847 0000-0003-3550-5378 0000-0003-3307-4340 0000-0001-9691-1906
    Record's date: 2024-10-19
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.mdpi.com/2218-273X/10/6/844
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Biomolecules. 10 (6): 1-14
    APA: Grau-Bove, Carme; Gonzalez-Quilen, Carlos; Terra, Ximena; Blay, M Teresa; Beltran-Debon, Raul; Jorba-Martin, Rosa; Espina, Beatriz; Pinent, Montserrat (2020). Effects of flavanols on enteroendocrine secretion. Biomolecules, 10(6), 1-14. DOI: 10.3390/biom10060844
    Article's DOI: 10.3390/biom10060844
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2020
    Publication Type: Journal Publications
  • Keywords:

    Biochemistry,Biochemistry & Molecular Biology,Molecular Biology
    Vitis
    Swine
    Seeds
    Pyy
    Procyanidins
    Proanthocyanidins
    Proanthocyanidin
    Plant extracts
    Pig
    Peptide yy
    Metabolism
    Intestine
    Humans
    Gut hormones
    Grape seed extract
    Glucagon-like peptide-1
    Glucagon-like peptide 1
    Glp-1
    Ghrelin production
    Gastrointestinal tract
    Flavonoids
    Cholecystokinin
    Cells
    Cck
    Bitter
    Animals
    Absorption
    pyy
    glp-1
    flavonoids
    cck
    Química
    Molecular biology
    Materiais
    General medicine
    Farmacia
    Ensino
    Biochemistry & molecular biology
    Biochemistry
  • Documents:

  • Cerca a google

    Search to google scholar