Author, as appears in the article.: Margalef R; Bosque M; Monclús P; Flores P; Minaya-Muñoz F; Valera-Garrido F; Santafé MM

Department: Ciències Mèdiques Bàsiques

URV's Author/s: Santafé Martínez, Manuel

Keywords: Twitch response Stimulation Potentials Pain Muscle Electrotaxis Common

Abstract: © 2020 R. Margalef et al. An increase in the spontaneous release of acetylcholine (ACh) at the motor endplate is directly related to the generation of myofascial trigger points (MTrPs). In this study, percutaneous electric fields were applied to an animal model of MTrPs with high levels of spontaneous ACh release. All experiments were performed on Swiss mice and Sprague Dawley rats. For evaluating the spontaneous neurotransmission, intracellular recordings were performed, and the frequency of miniature endplate potentials was evaluated. Electromyographic recordings were also conducted to evaluate the endplate noise. Finally, the number and strength of local twitch responses (LTR) were evaluated using ultrasound recordings. The protocols used for the electric currents were 0.4 mA for five seconds and four repetitions (protocol 1), 1.5 mA for five seconds and three repetitions (protocol 2), and 3 mA for three seconds and three repetitions (protocol 3). After a subcutaneous injection of neostigmine (NTG), a great increase was observed in the frequency of mEPPs, together with an elevated endplate noise. Protocols 2 and 3 were the most effective. Protocol 3 could completely reverse the action of NTG at both three hours and 24 hours, respectively. The application of percutaneous currents produced both an increase in the number (144%) and in the speed (230% faster) of LTR compared with dry needling. In conclusion, higher doses of electrical current are more effective for decreasing MTrPs findings in an animal model.

Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Odontología Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Integrative & complementary medicine Farmacia Ensino Engenharias iv Engenharias ii Engenharias i Enfermagem Educação física Economia Complementary and alternative medicine Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Astronomia / física Administração, ciências contábeis e turismo

licence for use: https://creativecommons.org/licenses/by/3.0/es/

Author's mail: manuel.santafe@urv.cat

Author identifier: 0000-0002-5462-5108

Record's date: 2023-02-19

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.hindawi.com/journals/ecam/2020/4173218/

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Evidence-Based Complementary And Alternative Medicine. 2020 (4173218): 4173218-

APA: Margalef R; Bosque M; Monclús P; Flores P; Minaya-Muñoz F; Valera-Garrido F; Santafé MM (2020). Percutaneous Application of Galvanic Current in Rodents Reverses Signs of Myofascial Trigger Points. Evidence-Based Complementary And Alternative Medicine, 2020(4173218), 4173218-. DOI: 10.1155/2020/4173218

Article's DOI: 10.1155/2020/4173218

Entity: Universitat Rovira i Virgili

Journal publication year: 2020

Publication Type: Journal Publications