Author, as appears in the article.: Oliveira, Mariana M; Trevilato, Tania M B; Segura-Munoz, Susana, I; Aragon, Davi C; Alves, Larissa G; Nadal, Marti; Marques, Montse; Domingo, Jose L; Sierra, Jordi; Camelo Jr, Jose Simon
Department: Ciències Mèdiques Bàsiques
URV's Author/s: Domingo Roig, José Luis / Marquès Bueno, Montserrat / Nadal Lomas, Martí
Keywords: Trace-elements Trace elements Premature infant Necrotizing enterocolitis Milk, human Micronutrients Mercury concentration Lead Lactation Infants Infant, very low birth weight Infant, premature Infant, newborn Infant Humans Human milk Health-risk Female Exposure Cadmium Breast-milk Breast milk Biomonitoring Bayes theorem Animals micronutrients human milk breast milk biomonitoring
Abstract: © 2020 The Authors Concentrated human milk (HM-concentrate) can be obtained from the simple and inexpensive method of donated breast milk direct lyophilization. A previous study reported that HM-concentrate contains the adequate amount of main macro- and micronutrients for use as a nutritional resource for preterm infants with very low birth weight admitted to neonatal intensive care units. However, further details need to be elucidated about HM-concentrate composition, particularly its content of essential and potentially toxic trace elements. Therefore, this study aimed to determine the concentration of essential and toxic elements in human milk considered baseline (HM-baseline) and HM-concentrate, as well as to quantify changes in concentration of these elements after the HM concentration process. The concentration of Aluminum, Arsenic, Cadmium, Chromium, Iron, Mercury, Manganese, Nickel, Lead, Selenium, Tin, and Thallium was analyzed by inductively coupled plasma-mass spectrometry (ICP-MS). Moreover, Bayesian linear mixed effect models were applied to estimate the mean difference between HM-baseline and HM-concentrate samples. After comparison (HM-concentrate versus HM-baseline), a significant increase in concentration was observed only for Manganese (0.80 μg/L; 95% CrI [0.16; 1.43]) and Selenium (6.74 μg/L; 95% CrI [4.66; 8.86]), while Lead concentration (−6.13 μg/L; 95% CrI [-8.63; −3.61]) decreased. This study provides latest and reliable information about HM composition. After milk concentration by lyophilization, there was a significant increase only in the essential elements Manganese and Selenium. The essential micronutrient content in HM-concentrate was similar or higher than that in preterm mothers' milk, which suggests it is viable for nutritional support of preterm infants. In addition, the low concentrations of potentially toxic elements in HM-concentrate indicates that it is safe for consumption by premature newborns.
Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Public, environmental & occupational health Public health, environmental and occupational health Psicología Planejamento urbano e regional / demografia Odontología Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Geociências General medicine General environmental science Farmacia Environmental sciences Environmental science (miscellaneous) Environmental science (all) Ensino Engenharias iii Engenharias ii Engenharias i Enfermagem Educação física Direito Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Biochemistry Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 00139351
Author's mail: montserrat.marques@urv.cat joseluis.domingo@urv.cat marti.nadal@urv.cat
Author identifier: 0000-0001-6302-8578 0000-0001-6647-9470 0000-0002-0217-4827
Record's date: 2025-03-22
Paper version: info:eu-repo/semantics/publishedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Paper original source: Environmental Research. 188 (109733): 109733-
APA: Oliveira, Mariana M; Trevilato, Tania M B; Segura-Munoz, Susana, I; Aragon, Davi C; Alves, Larissa G; Nadal, Marti; Marques, Montse; Domingo, Jose L; (2020). Essential and toxic elements in human milk concentrate with human milk lyophilizate: A preclinical study. Environmental Research, 188(109733), 109733-. DOI: 10.1016/j.envres.2020.109733
Entity: Universitat Rovira i Virgili
Journal publication year: 2020
Publication Type: Journal Publications