Author, as appears in the article.: Montane, Xavier; Kowalczyk, Oliwia; Reig-Vano, Belen; Bajek, Anna; Roszkowski, Krzysztof; Tomczyk, Remigiusz; Pawliszak, Wojciech; Giamberini, Marta; Mocek-Plociniak, Agnieszka; Tylkowski, Bartosz
Department: Enginyeria Química
URV's Author/s: Giamberini, Marta / Montané Montané, Xavier / Reig Vañó, Belén / Tylkowski, Bartosz
Keywords: Tumor-growth; Prostate-cancer; Polyphenols; Phytochemicals; P-coumaric acid; Neoplasms; Natural health products; Molecular-mechanisms; Inhibits proliferation; In-vitro; Humans; Flavonoids; Ellagic acid; Drug-resistance; Drug therapy; Drug synergism; Dietary supplements; Cell lung-cancer; Cancer; Apoptosis; Antioxidants; Antineoplastic agents; Anticancer therapy; phytochemicals; natural health products; flavonoids; dietary supplements; cancer; antioxidants; anticancer therapy
Abstract: The development of anticancer therapies that involve natural drugs has undergone exponential growth in recent years. Among the natural compounds that produce beneficial effects on human health, polyphenols have shown potential therapeutic applications in cancer due to their protective functions in plants, their use as food additives, and their excellent antioxidant properties. The possibility of combining conventional drugs-which are usually more aggressive than natural compounds-with polyphenols offers very valuable advantages such as the building of more efficient anticancer therapies with less side effects on human health. This review shows a wide range of trials in which polyphenolic compounds play a crucial role as anticancer medicines alone or in combination with other drugs at different stages of cancer: cancer initiation, promotion, and growth or progression. Moreover, the future directions in applications of various polyphenols in cancer therapy are emphasized.
Thematic Areas: Zootecnia / recursos pesqueiros; Saúde coletiva; Química; Psicología; Planejamento urbano e regional / demografia; Physical and theoretical chemistry; Pharmaceutical science; Organic chemistry; Odontología; Nutrição; Molecular medicine; Medicine (miscellaneous); Medicina veterinaria; Medicina iii; Medicina ii; Medicina i; Materiais; Matemática / probabilidade e estatística; Interdisciplinar; Geografía; General medicine; Farmacia; Ensino; Engenharias iv; Engenharias iii; Engenharias ii; Engenharias i; Educação física; Economia; Drug discovery; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Ciências ambientais; Ciências agrárias i; Ciência de alimentos; Ciência da computação; Chemistry, organic; Chemistry, multidisciplinary; Chemistry (miscellaneous); Biotecnología; Biodiversidade; Biochemistry & molecular biology; Astronomia / física; Analytical chemistry
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 1420-3049
Author's mail: xavier.montane@urv.cat; belen.reig@estudiants.urv.cat; belen.reig@estudiants.urv.cat; marta.giamberini@urv.cat; bartosz.tylkowski@urv.cat
Record's date: 2025-01-28
Journal volume: 25
Paper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.mdpi.com/1420-3049/25/15/3342
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Paper original source: Molecules. 25 (15): E3342-
APA: Montane, Xavier; Kowalczyk, Oliwia; Reig-Vano, Belen; Bajek, Anna; Roszkowski, Krzysztof; Tomczyk, Remigiusz; Pawliszak, Wojciech; Giamberini, Marta; (2020). Current Perspectives of the Applications of Polyphenols and Flavonoids in Cancer Therapy. Molecules, 25(15), E3342-. DOI: 10.3390/molecules25153342
Article's DOI: 10.3390/molecules25153342
Entity: Universitat Rovira i Virgili
Journal publication year: 2020
Publication Type: Journal Publications
Repositori URV