Author, as appears in the article.: Montané X; Kowalczyk O; Reig-Vano B; Bajek A; Roszkowski K; Tomczyk R; Pawliszak W; Giamberini M; Mocek-Płóciniak A; Tylkowski B

Department: Enginyeria Química

URV's Author/s: Giamberini, Marta / Montané Montané, Xavier / Reig Vañó, Belén / Tylkowski, Bartosz

Keywords: Tumor-growth Prostate-cancer Polyphenols Phytochemicals P-coumaric acid Natural health products Molecular-mechanisms Inhibits proliferation In-vitro Flavonoids Ellagic acid Drug-resistance Dietary supplements Cell lung-cancer Cancer Apoptosis Antioxidants Anticancer therapy phytochemicals natural health products flavonoids dietary supplements cancer antioxidants anticancer therapy

Abstract: The development of anticancer therapies that involve natural drugs has undergone exponential growth in recent years. Among the natural compounds that produce beneficial effects on human health, polyphenols have shown potential therapeutic applications in cancer due to their protective functions in plants, their use as food additives, and their excellent antioxidant properties. The possibility of combining conventional drugs-which are usually more aggressive than natural compounds-with polyphenols offers very valuable advantages such as the building of more efficient anticancer therapies with less side effects on human health. This review shows a wide range of trials in which polyphenolic compounds play a crucial role as anticancer medicines alone or in combination with other drugs at different stages of cancer: cancer initiation, promotion, and growth or progression. Moreover, the future directions in applications of various polyphenols in cancer therapy are emphasized.

Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Physical and theoretical chemistry Pharmaceutical science Organic chemistry Odontología Nutrição Molecular medicine Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Interdisciplinar Geografía General medicine Farmacia Ensino Engenharias iv Engenharias iii Engenharias ii Engenharias i Educação física Economia Drug discovery Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Chemistry, organic Chemistry, multidisciplinary Chemistry (miscellaneous) Biotecnología Biodiversidade Biochemistry & molecular biology Astronomia / física Analytical chemistry

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 1420-3049

Author's mail: belen.reig@urv.cat bartosz.tylkowski@urv.cat xavier.montane@urv.cat marta.giamberini@urv.cat belen.reig@urv.cat

Author identifier: 0000-0002-4163-0178 0000-0002-1426-239X 0000-0001-8278-3552

Record's date: 2023-02-19

Journal volume: 25

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.mdpi.com/1420-3049/25/15/3342

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Molecules. 25 (15):

APA: Montané X; Kowalczyk O; Reig-Vano B; Bajek A; Roszkowski K; Tomczyk R; Pawliszak W; Giamberini M; Mocek-Płóciniak A; Tylkowski B (2020). Current Perspectives of the Applications of Polyphenols and Flavonoids in Cancer Therapy. Molecules, 25(15), -. DOI: 10.3390/molecules25153342

Article's DOI: 10.3390/molecules25153342

Entity: Universitat Rovira i Virgili

Journal publication year: 2020

Publication Type: Journal Publications