Articles producció científicaQuímica Física i Inorgànica

Surface-Enhanced Raman Scattering Detection of Nucleic Acids Exhibiting Sterically Accessible Guanines Using Ruthenium-Polypyridyl Reagents

  • Identification data

    Identifier:  imarina:8263152
    Handle: https://hdl.handle.net/20.500.11797/imarina8263152
    Authors:  Martínez-Calvo, M; Guerrini, L; Rodríguez, J; Alvarez-Puebla, RA; Mascareñas, JL
    Abstract:
    Here, we report the application of surface-enhanced Raman scattering (SERS) spectroscopy as a rapid and practical tool for assessing the formation of coordinative adducts between nucleic acid guanines and ruthenium polypyridyl reagents. The technology provides a practical approach for the wash-free and quick identification of nucleic acid structures exhibiting sterically accessible guanines. This is demonstrated for the detection of a quadruplex-forming sequence present in the promoter region of the c-myc oncogene, which exhibits a nonpaired, reactive guanine at a flanking position of the G-quartets.

  • Others:

    Link to the original source: https://pubs.acs.org/doi/10.1021/acs.jpclett.0c02148
    APA: Martínez-Calvo, M; Guerrini, L; Rodríguez, J; Alvarez-Puebla, RA; Mascareñas, JL (2020). Surface-Enhanced Raman Scattering Detection of Nucleic Acids Exhibiting Sterically Accessible Guanines Using Ruthenium-Polypyridyl Reagents. Journal of Physical Chemistry Letters, 11(17), 7218-7223. DOI: 10.1021/acs.jpclett.0c02148
    Paper original source: Journal of Physical Chemistry Letters. 11 (17): 7218-7223
    Article's DOI: 10.1021/acs.jpclett.0c02148
    Journal publication year: 2020-09-03
    Entity: Universitat Rovira i Virgili
    Paper version: info:eu-repo/semantics/acceptedVersion
    Record's date: 2026-05-09
    URV's Author/s: Alvarez Puebla, Ramon Angel / Guerrini, Luca
    Department: Química Física i Inorgànica
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Publication Type: Journal Publications
    ISSN: 19487185
    Author, as appears in the article.: Martínez-Calvo, M; Guerrini, L; Rodríguez, J; Alvarez-Puebla, RA; Mascareñas, JL
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Research group: Grupo de Plasmonica y Ultradeteccion
    Thematic Areas: Physics, atomic, molecular & chemical, Physical and theoretical chemistry, Nanoscience and nanotechnology, Nanoscience & nanotechnology, Materials science, multidisciplinary, Materials science (miscellaneous), Materials science (all), General medicine, General materials science, Chemistry, physical, Astronomia / física
    Author's mail: ramon.alvarez@urv.cat, ramon.alvarez@urv.cat, luca.guerrini@urv.cat, luca.guerrini@urv.cat

  • Keywords:

    Spectroscopy
    Ruthenation
    Rna
    Dna interactions
    Direct quantification
    Complexes
    Binding
    Chemistry
    Physical
    Materials Science (Miscellaneous)
    Materials Science
    Multidisciplinary
    Nanoscience & Nanotechnology
    Nanoscience and Nanotechnology
    Physical and Theoretical Chemistry
    Physics
    Atomic
    Molecular & Chemical
    Materials science (all)
    General medicine
    General materials science
    Astronomia / física

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