Gold-Catalyzed Synthesis of Small Rings

Identifier:  imarina:9138937

Handle: https://hdl.handle.net/20.500.11797/imarina9138937

Authors:  Mato, Mauro; Franchino, Allegra; Garcia-Morales, Cristina; Echavarren, Antonio M

Abstract:
© Three- and four-membered rings, widespread motifs in nature and medicinal chemistry, have fascinated chemists ever since their discovery. However, due to energetic considerations, small rings are often difficult to assemble. In this regard, homogeneous gold catalysis has emerged as a powerful tool to construct these highly strained carbocycles. This review aims to provide a comprehensive summary of all the major advances and discoveries made in the gold-catalyzed synthesis of cyclopropanes, cyclopropenes, cyclobutanes, cyclobutenes, and their corresponding heterocyclic or heterosubstituted analogs.