Articles producció científica> Ciències Mèdiques Bàsiques

ERG11 polymorphism in voriconazole-resistant candida tropicalis: Weak role of erg11 expression, ergosterol content, and membrane permeability

  • Identification data

    Identifier: imarina:9139032
    Authors:
    Navarro-Rodríguez PLópez-Fernández LMartin-Vicente AGuarro JCapilla J
    Abstract:
    © 2020 American Society for Microbiology. All Rights Reserved. Mutations in ERG11 were detected by gene sequencing and amino acid alignment in 18 Candida tropicalis strains with different degrees of sensitivity to voriconazole (VRC). ERG11 expression, sterol content, and membrane permeability were also evaluated. We report three missense mutations in ERG11 that resulted in resistance to VRC. The transcriptional levels of ERG11 as well as the ergosterol content and membrane permeability demonstrated no correlation to only a slight correlation with the obtained MIC values, but the data did suggest a tendency toward such a correlation.
  • Others:

    Author, as appears in the article.: Navarro-Rodríguez P; López-Fernández L; Martin-Vicente A; Guarro J; Capilla J
    Department: Ciències Mèdiques Bàsiques
    URV's Author/s: Alkhoury, Nadine / Capilla Luque, Javier / Guarro Artigas, Josep
    Keywords: Voriconazole Gene expression Ergosterol Erg11 mutations Erg11 C. tropicalis Azole resistance
    Abstract: © 2020 American Society for Microbiology. All Rights Reserved. Mutations in ERG11 were detected by gene sequencing and amino acid alignment in 18 Candida tropicalis strains with different degrees of sensitivity to voriconazole (VRC). ERG11 expression, sterol content, and membrane permeability were also evaluated. We report three missense mutations in ERG11 that resulted in resistance to VRC. The transcriptional levels of ERG11 as well as the ergosterol content and membrane permeability demonstrated no correlation to only a slight correlation with the obtained MIC values, but the data did suggest a tendency toward such a correlation.
    Thematic Areas: Saúde coletiva Química Pharmacology (medical) Pharmacology & pharmacy Pharmacology Odontología Nutrição Microbiology Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Interdisciplinar Infectious diseases Farmacia Ensino Engenharias iv Engenharias iii Engenharias ii Enfermagem Educação física Educação Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Astronomia / física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: josep.guarro@urv.cat nadine.alkhoury@estudiants.urv.cat nadine.alkhoury@estudiants.urv.cat nadine.alkhoury@estudiants.urv.cat nadine.alkhoury@estudiants.urv.cat javier.capilla@urv.cat
    Author identifier: 0000-0002-7839-7568 0000-0002-0765-6403
    Record's date: 2024-07-27
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: https://aac.asm.org/content/65/1/e00325-20
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Antimicrobial Agents And Chemotherapy. 65 (1):
    APA: Navarro-Rodríguez P; López-Fernández L; Martin-Vicente A; Guarro J; Capilla J (2021). ERG11 polymorphism in voriconazole-resistant candida tropicalis: Weak role of erg11 expression, ergosterol content, and membrane permeability. Antimicrobial Agents And Chemotherapy, 65(1), -. DOI: 10.1128/AAC.00325-20
    Article's DOI: 10.1128/AAC.00325-20
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2021
    Publication Type: Journal Publications
  • Keywords:

    Infectious Diseases,Microbiology,Pharmacology,Pharmacology & Pharmacy,Pharmacology (Medical)
    Voriconazole
    Gene expression
    Ergosterol
    Erg11 mutations
    Erg11
    C. tropicalis
    Azole resistance
    Saúde coletiva
    Química
    Pharmacology (medical)
    Pharmacology & pharmacy
    Pharmacology
    Odontología
    Nutrição
    Microbiology
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Matemática / probabilidade e estatística
    Interdisciplinar
    Infectious diseases
    Farmacia
    Ensino
    Engenharias iv
    Engenharias iii
    Engenharias ii
    Enfermagem
    Educação física
    Educação
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
    Biodiversidade
    Astronomia / física
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