Author, as appears in the article.: Navarro-Rodriguez, Patricia; Lopez-Fernandez, Loida; Martin-Vicente, Adela; Guarro, Josep; Capilla, Javier
Department: Ciències Mèdiques Bàsiques
URV's Author/s: Alkhoury, Nadine / Capilla Luque, Javier / Guarro Artigas, Josep
Keywords: Voriconazole; Permeability; Microbial sensitivity tests; Humans; Gene expression; Fungal proteins; Fluconazole; Ergosterol; Erg11 mutations; Erg11; Drug resistance, fungal; Candidiasis; Candida tropicalis; Candida albicans; C. tropicalis; Azoles; Azole resistance; Antifungal agents
Abstract: © 2020 American Society for Microbiology. All Rights Reserved. Mutations in ERG11 were detected by gene sequencing and amino acid alignment in 18 Candida tropicalis strains with different degrees of sensitivity to voriconazole (VRC). ERG11 expression, sterol content, and membrane permeability were also evaluated. We report three missense mutations in ERG11 that resulted in resistance to VRC. The transcriptional levels of ERG11 as well as the ergosterol content and membrane permeability demonstrated no correlation to only a slight correlation with the obtained MIC values, but the data did suggest a tendency toward such a correlation.
Thematic Areas: Saúde coletiva; Química; Pharmacology (medical); Pharmacology & pharmacy; Pharmacology; Odontología; Nutrição; Microbiology; Medicina veterinaria; Medicina iii; Medicina ii; Medicina i; Materiais; Matemática / probabilidade e estatística; Interdisciplinar; Infectious diseases; Farmacia; Ensino; Engenharias iv; Engenharias iii; Engenharias ii; Enfermagem; Educação física; Educação; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Ciências agrárias i; Ciência de alimentos; Biotecnología; Biodiversidade; Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: nadine.alkhoury@estudiants.urv.cat; nadine.alkhoury@estudiants.urv.cat; nadine.alkhoury@estudiants.urv.cat; nadine.alkhoury@estudiants.urv.cat; javier.capilla@urv.cat
Record's date: 2025-01-08
Paper version: info:eu-repo/semantics/acceptedVersion
Link to the original source: https://aac.asm.org/content/65/1/e00325-20
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Paper original source: Antimicrobial Agents And Chemotherapy. 65 (1): e00325-20-
APA: Navarro-Rodriguez, Patricia; Lopez-Fernandez, Loida; Martin-Vicente, Adela; Guarro, Josep; Capilla, Javier (2021). ERG11 polymorphism in voriconazole-resistant candida tropicalis: Weak role of erg11 expression, ergosterol content, and membrane permeability. Antimicrobial Agents And Chemotherapy, 65(1), e00325-20-. DOI: 10.1128/AAC.00325-20
Article's DOI: 10.1128/AAC.00325-20
Entity: Universitat Rovira i Virgili
Journal publication year: 2021
Publication Type: Journal Publications
Repositori URV