Author, as appears in the article.: Navarro-Rodríguez P; López-Fernández L; Martin-Vicente A; Guarro J; Capilla J

Department: Ciències Mèdiques Bàsiques

URV's Author/s: Capilla Luque, Javier / Guarro Artigas, Josep / Miró Martínez, Eric

Keywords: Voriconazole Gene expression Ergosterol Erg11 mutations Erg11 C. tropicalis Azole resistance

Abstract: © 2020 American Society for Microbiology. All Rights Reserved. Mutations in ERG11 were detected by gene sequencing and amino acid alignment in 18 Candida tropicalis strains with different degrees of sensitivity to voriconazole (VRC). ERG11 expression, sterol content, and membrane permeability were also evaluated. We report three missense mutations in ERG11 that resulted in resistance to VRC. The transcriptional levels of ERG11 as well as the ergosterol content and membrane permeability demonstrated no correlation to only a slight correlation with the obtained MIC values, but the data did suggest a tendency toward such a correlation.

Thematic Areas: Saúde coletiva Química Pharmacology (medical) Pharmacology & pharmacy Pharmacology Odontología Nutrição Microbiology Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Interdisciplinar Infectious diseases Farmacia Ensino Engenharias iv Engenharias iii Engenharias ii Enfermagem Educação física Educação Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Astronomia / física

licence for use: https://creativecommons.org/licenses/by/3.0/es/

Author's mail: josep.guarro@urv.cat javier.capilla@urv.cat 0 0 0

Author identifier: 0000-0002-7839-7568 0000-0002-0765-6403

Record's date: 2023-09-23

Papper version: info:eu-repo/semantics/acceptedVersion

Link to the original source: https://aac.asm.org/content/65/1/e00325-20

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Antimicrobial Agents And Chemotherapy. 65 (1):

APA: Navarro-Rodríguez P; López-Fernández L; Martin-Vicente A; Guarro J; Capilla J (2021). ERG11 polymorphism in voriconazole-resistant candida tropicalis: Weak role of erg11 expression, ergosterol content, and membrane permeability. Antimicrobial Agents And Chemotherapy, 65(1), -. DOI: 10.1128/AAC.00325-20

Article's DOI: 10.1128/AAC.00325-20

Entity: Universitat Rovira i Virgili

Journal publication year: 2021

Publication Type: Journal Publications