Articles producció científicaCiències Mèdiques Bàsiques

ERG11 polymorphism in voriconazole-resistant candida tropicalis: Weak role of erg11 expression, ergosterol content, and membrane permeability

  • Identification data

    Identifier:  imarina:9139032
    Handle: https://hdl.handle.net/20.500.11797/imarina9139032
    Authors:  Navarro-Rodríguez, P; López-Fernández, L; Martin-Vicente, A; Guarro, J; Capilla, J
    Abstract:
    © 2020 American Society for Microbiology. All Rights Reserved. Mutations in ERG11 were detected by gene sequencing and amino acid alignment in 18 Candida tropicalis strains with different degrees of sensitivity to voriconazole (VRC). ERG11 expression, sterol content, and membrane permeability were also evaluated. We report three missense mutations in ERG11 that resulted in resistance to VRC. The transcriptional levels of ERG11 as well as the ergosterol content and membrane permeability demonstrated no correlation to only a slight correlation with the obtained MIC values, but the data did suggest a tendency toward such a correlation.

  • Others:

    Link to the original source: https://aac.asm.org/content/65/1/e00325-20
    APA: Navarro-Rodríguez, P; López-Fernández, L; Martin-Vicente, A; Guarro, J; Capilla, J (2021). ERG11 polymorphism in voriconazole-resistant candida tropicalis: Weak role of erg11 expression, ergosterol content, and membrane permeability. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 65(1), e00325-20-. DOI: 10.1128/AAC.00325-20
    Paper original source: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 65 (1): e00325-20-
    Article's DOI: 10.1128/AAC.00325-20
    Journal publication year: 2021-01-01
    Entity: Universitat Rovira i Virgili
    Paper version: info:eu-repo/semantics/acceptedVersion
    Record's date: 2026-05-09
    URV's Author/s: Alkhoury, Nadine / Capilla Luque, Javier / Guarro Artigas, Josep
    Department: Ciències Mèdiques Bàsiques
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Publication Type: Journal Publications
    Author, as appears in the article.: Navarro-Rodríguez, P; López-Fernández, L; Martin-Vicente, A; Guarro, J; Capilla, J
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Thematic Areas: Pharmacology (medical), Pharmacology & pharmacy, Pharmacology, Microbiology, Infectious diseases, Biotecnología, Biodiversidade, Administração pública e de empresas, ciências contábeis e turismo
    Author's mail: nadine.alkhoury@urv.cat, nadine.alkhoury@urv.cat, nadine.alkhoury@urv.cat, nadine.alkhoury@urv.cat, nadine.alkhoury@urv.cat, nadine.alkhoury@urv.cat, javier.capilla@urv.cat, javier.capilla@urv.cat

  • Keywords:

    Voriconazole
    Permeability
    Microbial sensitivity tests
    Humans
    Gene expression
    Fungal proteins
    Fluconazole
    Ergosterol
    Erg11 mutations
    Erg11
    Drug resistance
    fungal
    Candidiasis
    Candida tropicalis
    Candida albicans
    C. tropicalis
    Azoles
    Azole resistance
    Antifungal agents
    Infectious Diseases
    Microbiology
    Pharmacology
    Pharmacology & Pharmacy
    Pharmacology (Medical)
    Biotecnología
    Biodiversidade
    Administração pública e de empresas
    ciências contábeis e turismo

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