Autor según el artículo: Navarro-Rodriguez, Patricia; Lopez-Fernandez, Loida; Martin-Vicente, Adela; Guarro, Josep; Capilla, Javier
Departamento: Ciències Mèdiques Bàsiques
Autor/es de la URV: Alkhoury, Nadine / Capilla Luque, Javier / Guarro Artigas, Josep
Palabras clave: Voriconazole; Permeability; Microbial sensitivity tests; Humans; Gene expression; Fungal proteins; Fluconazole; Ergosterol; Erg11 mutations; Erg11; Drug resistance, fungal; Candidiasis; Candida tropicalis; Candida albicans; C. tropicalis; Azoles; Azole resistance; Antifungal agents
Resumen: © 2020 American Society for Microbiology. All Rights Reserved. Mutations in ERG11 were detected by gene sequencing and amino acid alignment in 18 Candida tropicalis strains with different degrees of sensitivity to voriconazole (VRC). ERG11 expression, sterol content, and membrane permeability were also evaluated. We report three missense mutations in ERG11 that resulted in resistance to VRC. The transcriptional levels of ERG11 as well as the ergosterol content and membrane permeability demonstrated no correlation to only a slight correlation with the obtained MIC values, but the data did suggest a tendency toward such a correlation.
Áreas temáticas: Saúde coletiva; Química; Pharmacology (medical); Pharmacology & pharmacy; Pharmacology; Odontología; Nutrição; Microbiology; Medicina veterinaria; Medicina iii; Medicina ii; Medicina i; Materiais; Matemática / probabilidade e estatística; Interdisciplinar; Infectious diseases; Farmacia; Ensino; Engenharias iv; Engenharias iii; Engenharias ii; Enfermagem; Educação física; Educação; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Ciências agrárias i; Ciência de alimentos; Biotecnología; Biodiversidade; Astronomia / física
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: nadine.alkhoury@estudiants.urv.cat; nadine.alkhoury@estudiants.urv.cat; nadine.alkhoury@estudiants.urv.cat; nadine.alkhoury@estudiants.urv.cat; javier.capilla@urv.cat
Fecha de alta del registro: 2025-01-08
Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
Enlace a la fuente original: https://aac.asm.org/content/65/1/e00325-20
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Antimicrobial Agents And Chemotherapy. 65 (1): e00325-20-
Referencia de l'ítem segons les normes APA: Navarro-Rodriguez, Patricia; Lopez-Fernandez, Loida; Martin-Vicente, Adela; Guarro, Josep; Capilla, Javier (2021). ERG11 polymorphism in voriconazole-resistant candida tropicalis: Weak role of erg11 expression, ergosterol content, and membrane permeability. Antimicrobial Agents And Chemotherapy, 65(1), e00325-20-. DOI: 10.1128/AAC.00325-20
DOI del artículo: 10.1128/AAC.00325-20
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2021
Tipo de publicación: Journal Publications
Repositori URV