Author, as appears in the article.: Hernandez-Baixauli J; Puigbò P; Torrell H; Palacios-Jordan H; Ripoll VJR; Caimari A; Bas JMD; Baselga-Escudero L; Mulero M

Department: Bioquímica i Biotecnologia

URV's Author/s: BASELGA ESCUDERO, LAURA / Mulero Abellán, Miguel

Keywords: O-coumaric acid Microbial dysbiosis Metagenomics Metabolomics Metabolic profile Hippurate Gut microbiota Dysbiosis biomarkers Dysbiosis bi-omarkers Diacylglycerol 34:2 3-hppa

Abstract: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. Obesity is one of the most incident and concerning disease worldwide. Definite strategies to prevent obesity and related complications remain elusive. Among the risk factors of the onset of obesity, gut microbiota might play an important role in the pathogenesis of the disease, and it has received extensive attention because it affects the host metabolism. In this study, we aimed to define a metabolic profile of the segregated obesity-associated gut dysbiosis risk factor. The study of the metabolome, in an obesity-associated gut dysbiosis model, provides a relevant way for the discrim-ination on the different biomarkers in the obesity onset. Thus, we developed a model of this obesity risk factors through the transference of gut microbiota from obese to non-obese male Wistar rats and performed a subsequent metabolic analysis in the receptor rats. Our results showed alterations in the lipid metabolism in plasma and in the phenylalanine metabolism in urine. In consequence, we have identified metabolic changes characterized by: (1) an increase in DG:34:2 in plasma, a decrease in hippurate, (2) an increase in 3-HPPA, and (3) an increase in o-coumaric acid. Hereby, we propose these metabolites as a metabolic profile associated to a segregated dysbiosis state related to obesity disease.

Thematic Areas: Química Molecular biology Materiais General medicine Farmacia Ensino Biochemistry & molecular biology Biochemistry

licence for use: https://creativecommons.org/licenses/by/3.0/es/

Author's mail: miquel.mulero@urv.cat

Record's date: 2023-02-19

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.mdpi.com/2218-273X/11/2/303

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Biomolecules. 11 (2): 1-22

APA: Hernandez-Baixauli J; Puigbò P; Torrell H; Palacios-Jordan H; Ripoll VJR; Caimari A; Bas JMD; Baselga-Escudero L; Mulero M (2021). A pilot study for metabolic profiling of obesity-associated microbial gut dysbiosis in male wistar rats. Biomolecules, 11(2), 1-22. DOI: 10.3390/biom11020303

Article's DOI: 10.3390/biom11020303

Entity: Universitat Rovira i Virgili

Journal publication year: 2021

Publication Type: Journal Publications