Author, as appears in the article.: Lopez, Carlos; Gibert-Ramos, Albert; Bosch, Ramon; Korzynska, Anna; Garcia-Rojo, Marcial; Bueno, Gloria; Francesc Garcia-Fontgivell, Joan; Martinez Gonzalez, Salome; Fontoura, Laia; Gras Navarro, Andrea; Sauras Colon, Esther; Casanova Ribes, Julia; Roszkowiak, Lukasz; Roso, Albert; Berenguer, Marta; Llobera, Montserrat; Baucells, Jordi; Lejeune, Marylene
Department: Ciències Mèdiques Bàsiques
URV's Author/s: BAUCELLS LLADÓS, JOAN / Berenguer Poblet, Marta / Bosch Príncep, Ramon / Garcia Fontgivell, Joan Francesc / GIBERT RAMOS, ALBERT / Gras Navarro, Andrea / Lejeune, Marylène Marie / Lopez Pablo, Carlos / Martínez González, María Salomé
Keywords: Triple negative breast neoplasms Retrospective studies Prognosis Middle aged Lymphatic metastasis Lymph nodes Immunity Humans Follow-up studies Female Axilla
Abstract: © 2021 American Society for Investigative Pathology Breast cancer (BC) comprises four immunohistochemical surrogate subtypes of which triple-negative breast cancer (TNBC) has the highest risk of mortality. Axillary lymph nodes (ALNs) are the regions where BC cells first establish before distant metastasis, and the presence of tumor cells in the ALN causes an immune tolerance profile that contrasts with that of the nonmetastatic ALN (ALN−). However, few studies have compared the immune components of the ALNs− in BC subtypes. The present study aimed to determine whether differences between immune populations in the primary tumor and ALNs− were associated with the luminal A or TNBC subtype. We evaluated a retrospective cohort of 144 patients using paraffin-embedded biopsies. The TNBC samples tended to have a higher histologic grade and proliferation index and had higher levels of immune markers compared with luminal A in primary tumors and ALNs−. Two methods for validating the multivariate analysis found that histologic grade, intratumoral S100 dendritic cells, and CD8 T lymphocytes and CD57 natural killer cells in the ALNs− were factors associated with TNBC, whereas CD83 dendritic cells in the ALNs− were associated with the luminal A subtype. In conclusion, we found that intratumoral regions and ALNs− of TNBC contained higher concentrations of markers related to immune tolerance than luminal A. This finding partially explains the worse prognosis of patients with TNBC.
Thematic Areas: Pathology and forensic medicine Pathology Odontología Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: joanfrancesc.garcia@urv.cat ramon.bosch@urv.cat carlos.lopez@urv.cat mariasalome.martinez@urv.cat marylenemarie.lejeune@urv.cat marta.berenguer@urv.cat ramon.bosch@urv.cat
Author identifier: 0000-0003-1248-3065 0000-0001-6185-2889 0000-0001-8441-9404 0000-0002-6631-3777
Record's date: 2024-06-28
Papper version: info:eu-repo/semantics/acceptedVersion
Link to the original source: https://ajp.amjpathol.org/article/S0002-9440(20)30549-6/fulltext
Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: American Journal Of Pathology. 191 (3): 545-554
APA: Lopez, Carlos; Gibert-Ramos, Albert; Bosch, Ramon; Korzynska, Anna; Garcia-Rojo, Marcial; Bueno, Gloria; Francesc Garcia-Fontgivell, Joan; Martinez Go (2021). Differences in the Immune Response of the Nonmetastatic Axillary Lymph Nodes between Triple-Negative and Luminal A Breast Cancer Surrogate Subtypes. American Journal Of Pathology, 191(3), 545-554. DOI: 10.1016/j.ajpath.2020.11.008
Article's DOI: 10.1016/j.ajpath.2020.11.008
Entity: Universitat Rovira i Virgili
Journal publication year: 2021
Publication Type: Journal Publications
Repositori URV