Articles producció científica> Ciències Mèdiques Bàsiques

Differences in the Immune Response of the Nonmetastatic Axillary Lymph Nodes between Triple-Negative and Luminal A Breast Cancer Surrogate Subtypes

  • Datos identificativos

    Identificador: imarina:9162276
    Autores:
    Lopez, CarlosGibert-Ramos, AlbertBosch, RamonKorzynska, AnnaGarcia-Rojo, MarcialBueno, GloriaFrancesc Garcia-Fontgivell, JoanMartinez Gonzalez, SalomeFontoura, LaiaGras Navarro, AndreaSauras Colon, EstherCasanova Ribes, JuliaRoszkowiak, LukaszRoso, AlbertBerenguer, MartaLlobera, MontserratBaucells, JordiLejeune, Marylene
    Resumen:
    © 2021 American Society for Investigative Pathology Breast cancer (BC) comprises four immunohistochemical surrogate subtypes of which triple-negative breast cancer (TNBC) has the highest risk of mortality. Axillary lymph nodes (ALNs) are the regions where BC cells first establish before distant metastasis, and the presence of tumor cells in the ALN causes an immune tolerance profile that contrasts with that of the nonmetastatic ALN (ALN−). However, few studies have compared the immune components of the ALNs− in BC subtypes. The present study aimed to determine whether differences between immune populations in the primary tumor and ALNs− were associated with the luminal A or TNBC subtype. We evaluated a retrospective cohort of 144 patients using paraffin-embedded biopsies. The TNBC samples tended to have a higher histologic grade and proliferation index and had higher levels of immune markers compared with luminal A in primary tumors and ALNs−. Two methods for validating the multivariate analysis found that histologic grade, intratumoral S100 dendritic cells, and CD8 T lymphocytes and CD57 natural killer cells in the ALNs− were factors associated with TNBC, whereas CD83 dendritic cells in the ALNs− were associated with the luminal A subtype. In conclusion, we found that intratumoral regions and ALNs− of TNBC contained higher concentrations of markers related to immune tolerance than luminal A. This finding partially explains the worse prognosis of patients with TNBC.
  • Otros:

    Autor según el artículo: Lopez, Carlos; Gibert-Ramos, Albert; Bosch, Ramon; Korzynska, Anna; Garcia-Rojo, Marcial; Bueno, Gloria; Francesc Garcia-Fontgivell, Joan; Martinez Gonzalez, Salome; Fontoura, Laia; Gras Navarro, Andrea; Sauras Colon, Esther; Casanova Ribes, Julia; Roszkowiak, Lukasz; Roso, Albert; Berenguer, Marta; Llobera, Montserrat; Baucells, Jordi; Lejeune, Marylene
    Departamento: Ciències Mèdiques Bàsiques
    Autor/es de la URV: BAUCELLS LLADÓS, JOAN / Berenguer Poblet, Marta / Bosch Príncep, Ramon / Garcia Fontgivell, Joan Francesc / GIBERT RAMOS, ALBERT / Gras Navarro, Andrea / Lejeune, Marylène Marie / Lopez Pablo, Carlos / Martínez González, María Salomé
    Palabras clave: Triple negative breast neoplasms Retrospective studies Prognosis Middle aged Lymphatic metastasis Lymph nodes Immunity Humans Follow-up studies Female Axilla
    Resumen: © 2021 American Society for Investigative Pathology Breast cancer (BC) comprises four immunohistochemical surrogate subtypes of which triple-negative breast cancer (TNBC) has the highest risk of mortality. Axillary lymph nodes (ALNs) are the regions where BC cells first establish before distant metastasis, and the presence of tumor cells in the ALN causes an immune tolerance profile that contrasts with that of the nonmetastatic ALN (ALN−). However, few studies have compared the immune components of the ALNs− in BC subtypes. The present study aimed to determine whether differences between immune populations in the primary tumor and ALNs− were associated with the luminal A or TNBC subtype. We evaluated a retrospective cohort of 144 patients using paraffin-embedded biopsies. The TNBC samples tended to have a higher histologic grade and proliferation index and had higher levels of immune markers compared with luminal A in primary tumors and ALNs−. Two methods for validating the multivariate analysis found that histologic grade, intratumoral S100 dendritic cells, and CD8 T lymphocytes and CD57 natural killer cells in the ALNs− were factors associated with TNBC, whereas CD83 dendritic cells in the ALNs− were associated with the luminal A subtype. In conclusion, we found that intratumoral regions and ALNs− of TNBC contained higher concentrations of markers related to immune tolerance than luminal A. This finding partially explains the worse prognosis of patients with TNBC.
    Áreas temáticas: Pathology and forensic medicine Pathology Odontología Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: joanfrancesc.garcia@urv.cat ramon.bosch@urv.cat carlos.lopez@urv.cat mariasalome.martinez@urv.cat marylenemarie.lejeune@urv.cat ramon.bosch@urv.cat marta.berenguer@urv.cat
    Identificador del autor: 0000-0003-1248-3065 0000-0001-6185-2889 0000-0001-8441-9404 0000-0002-6631-3777
    Fecha de alta del registro: 2024-07-27
    Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
    Enlace a la fuente original: https://ajp.amjpathol.org/article/S0002-9440(20)30549-6/fulltext
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: American Journal Of Pathology. 191 (3): 545-554
    Referencia de l'ítem segons les normes APA: Lopez, Carlos; Gibert-Ramos, Albert; Bosch, Ramon; Korzynska, Anna; Garcia-Rojo, Marcial; Bueno, Gloria; Francesc Garcia-Fontgivell, Joan; Martinez Go (2021). Differences in the Immune Response of the Nonmetastatic Axillary Lymph Nodes between Triple-Negative and Luminal A Breast Cancer Surrogate Subtypes. American Journal Of Pathology, 191(3), 545-554. DOI: 10.1016/j.ajpath.2020.11.008
    DOI del artículo: 10.1016/j.ajpath.2020.11.008
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2021
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Pathology,Pathology and Forensic Medicine
    Triple negative breast neoplasms
    Retrospective studies
    Prognosis
    Middle aged
    Lymphatic metastasis
    Lymph nodes
    Immunity
    Humans
    Follow-up studies
    Female
    Axilla
    Pathology and forensic medicine
    Pathology
    Odontología
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    General medicine
    Farmacia
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Biotecnología
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