Author, as appears in the article.: Just-Borràs L; Cilleros-Mañé V; Hurtado E; Biondi O; Charbonnier F; Tomàs M; Garcia N; Tomàs J; Lanuza MA

Department: Ciències Mèdiques Bàsiques

URV's Author/s: Cilleros Mañé, Víctor / Garcia Sancho, Maria de les Neus / Just Borràs, Laia / Lanuza Escolano, María Angel / Tomás Ferré, José Maria / Tomas Marginet, Marta

Keywords: Trkb signaling Trkb kinase-activity Synaptic activity Soleus neuromuscular-junctions Skeletal-muscle Skeletal muscle New activity conditions Neurotrophic factor Neuromuscular junction Modulates acetylcholine-release Mitochondrial biogenesis Gene-expression Fast axonal-transport Endurance exercise C epsilon isoform Bdnf/trkb signaling Bdnf

Abstract: Physical exercise improves motor control and related cognitive abilities and reinforces neuroprotective mechanisms in the nervous system. As peripheral nerves interact with skeletal muscles at the neuromuscular junction, modifications of this bidirectional communication by physical activity are positive to preserve this synapse as it increases quantal content and resistance to fatigue, acetylcholine receptors expansion, and myocytes’ fast-to-slow functional transition. Here, we provide the intermediate step between physical activity and functional and morphological changes by analyzing the molecular adaptations in the skeletal muscle of the full BDNF/TrkB downstream signaling pathway, directly involved in acetylcholine release and synapse maintenance. After 45 days of training at different intensities, the BDNF/TrkB molecular phenotype of trained muscles from male B6SJLF1/J mice undergo a fast-to-slow transition without affecting motor neuron size. We provide further knowledge to understand how exercise induces muscle molecular adaptations towards a slower phenotype, resistant to prolonged trains of stimulation or activity that can be useful as therapeutic tools.

Thematic Areas: Zootecnia / recursos pesqueiros Spectroscopy Saúde coletiva Química Psicología Physical and theoretical chemistry Organic chemistry Odontología Nutrição Molecular biology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Inorganic chemistry Geociências Farmacia Engenharias iv Engenharias ii Engenharias i Educação física Computer science applications Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Chemistry, multidisciplinary Catalysis Biotecnología Biodiversidade Biochemistry & molecular biology Astronomia / física

licence for use: https://creativecommons.org/licenses/by/3.0/es/

Author's mail: victor.cilleros@urv.cat marta.tomas@urv.cat mariaangel.lanuza@urv.cat laia.just@urv.cat josepmaria.tomas@urv.cat victor.cilleros@urv.cat

Author identifier: 0000-0001-5690-9932 0000-0002-4151-1697 0000-0003-4795-4103 0000-0003-0473-3730 0000-0002-0406-0006 0000-0001-5690-9932

Record's date: 2023-09-23

Journal volume: 22

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.mdpi.com/1422-0067/22/9/4577

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: International Journal Of Molecular Sciences. 22 (9):

APA: Just-Borràs L; Cilleros-Mañé V; Hurtado E; Biondi O; Charbonnier F; Tomàs M; Garcia N; Tomàs J; Lanuza MA (2021). Running and swimming differently adapt the bdnf/trkb pathway to a slow molecular pattern at the nmj. International Journal Of Molecular Sciences, 22(9), -. DOI: 10.3390/ijms22094577

Article's DOI: 10.3390/ijms22094577

Entity: Universitat Rovira i Virgili

Journal publication year: 2021

Publication Type: Journal Publications