Articles producció científica> Ciències Mèdiques Bàsiques

Running and swimming differently adapt the bdnf/trkb pathway to a slow molecular pattern at the nmj

  • Datos identificativos

    Identificador: imarina:9202470
    Autores:
    Just-Borras, LaiaCilleros-Mane, VictorHurtado, EricaBiondi, OlivierCharbonnier, FredericTomas, MartaGarcia, NeusTomas, JosepLanuza, Maria A
    Resumen:
    Physical exercise improves motor control and related cognitive abilities and reinforces neuroprotective mechanisms in the nervous system. As peripheral nerves interact with skeletal muscles at the neuromuscular junction, modifications of this bidirectional communication by physical activity are positive to preserve this synapse as it increases quantal content and resistance to fatigue, acetylcholine receptors expansion, and myocytes’ fast-to-slow functional transition. Here, we provide the intermediate step between physical activity and functional and morphological changes by analyzing the molecular adaptations in the skeletal muscle of the full BDNF/TrkB downstream signaling pathway, directly involved in acetylcholine release and synapse maintenance. After 45 days of training at different intensities, the BDNF/TrkB molecular phenotype of trained muscles from male B6SJLF1/J mice undergo a fast-to-slow transition without affecting motor neuron size. We provide further knowledge to understand how exercise induces muscle molecular adaptations towards a slower phenotype, resistant to prolonged trains of stimulation or activity that can be useful as therapeutic tools.
  • Otros:

    Autor según el artículo: Just-Borras, Laia; Cilleros-Mane, Victor; Hurtado, Erica; Biondi, Olivier; Charbonnier, Frederic; Tomas, Marta; Garcia, Neus; Tomas, Josep; Lanuza, Maria A
    Departamento: Ciències Mèdiques Bàsiques
    Autor/es de la URV: Cilleros Mañé, Víctor / Garcia Sancho, Maria de les Neus / Hurtado Caballero, Erica / Just Borràs, Laia / Lanuza Escolano, María Angel / Tomás Ferré, José Maria / Tomas Marginet, Marta / TOMÀS ROIG, JORDI
    Palabras clave: Trkb signaling Trkb kinase-activity Synaptosomal-associated protein 25 Synaptic vesicles Synaptic activity Swimming Stxbp1 protein, mouse Soleus neuromuscular-junctions Snap25 protein, human Skeletal-muscle Skeletal muscle Signal transduction Running Protein-tyrosine kinases Protein serine-threonine kinases Physical conditioning, animal Ntrk2 protein, mouse New activity conditions Neurotrophic factor Neuromuscular junction Nerve growth factors Muscle, skeletal Munc18 proteins Motor neurons Modulates acetylcholine-release Mitochondrial biogenesis Mice, inbred strains Mice Membrane glycoproteins Male Gene-expression Fast axonal-transport Endurance exercise C epsilon isoform Brain-derived neurotrophic factor Bdnf/trkb signaling Bdnf protein, mouse Bdnf Animals
    Resumen: Physical exercise improves motor control and related cognitive abilities and reinforces neuroprotective mechanisms in the nervous system. As peripheral nerves interact with skeletal muscles at the neuromuscular junction, modifications of this bidirectional communication by physical activity are positive to preserve this synapse as it increases quantal content and resistance to fatigue, acetylcholine receptors expansion, and myocytes’ fast-to-slow functional transition. Here, we provide the intermediate step between physical activity and functional and morphological changes by analyzing the molecular adaptations in the skeletal muscle of the full BDNF/TrkB downstream signaling pathway, directly involved in acetylcholine release and synapse maintenance. After 45 days of training at different intensities, the BDNF/TrkB molecular phenotype of trained muscles from male B6SJLF1/J mice undergo a fast-to-slow transition without affecting motor neuron size. We provide further knowledge to understand how exercise induces muscle molecular adaptations towards a slower phenotype, resistant to prolonged trains of stimulation or activity that can be useful as therapeutic tools.
    Áreas temáticas: Zootecnia / recursos pesqueiros Spectroscopy Saúde coletiva Química Psicología Physical and theoretical chemistry Organic chemistry Odontología Nutrição Molecular biology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Inorganic chemistry Geociências Farmacia Engenharias iv Engenharias ii Engenharias i Educação física Computer science applications Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Chemistry, multidisciplinary Catalysis Biotecnología Biodiversidade Biochemistry & molecular biology Astronomia / física
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: laia.just@urv.cat marta.tomas@urv.cat erica.hurtado@urv.cat victor.cilleros@alumni.urv.cat josepmaria.tomas@urv.cat laia.just@urv.cat mariaangel.lanuza@urv.cat
    Identificador del autor: 0000-0003-0473-3730 0000-0002-4151-1697 0000-0001-5690-9932 0000-0002-0406-0006 0000-0003-0473-3730 0000-0003-4795-4103
    Fecha de alta del registro: 2024-10-12
    Volumen de revista: 22
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://www.mdpi.com/1422-0067/22/9/4577
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: International Journal Of Molecular Sciences. 22 (9): 4577-
    Referencia de l'ítem segons les normes APA: Just-Borras, Laia; Cilleros-Mane, Victor; Hurtado, Erica; Biondi, Olivier; Charbonnier, Frederic; Tomas, Marta; Garcia, Neus; Tomas, Josep; Lanuza, Ma (2021). Running and swimming differently adapt the bdnf/trkb pathway to a slow molecular pattern at the nmj. International Journal Of Molecular Sciences, 22(9), 4577-. DOI: 10.3390/ijms22094577
    DOI del artículo: 10.3390/ijms22094577
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2021
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Biochemistry & Molecular Biology,Catalysis,Chemistry, Multidisciplinary,Computer Science Applications,Inorganic Chemistry,Medicine (Miscellaneous),Molecular Biology,Organic Chemistry,Physical and Theoretical Chemistry,Spectroscopy
    Trkb signaling
    Trkb kinase-activity
    Synaptosomal-associated protein 25
    Synaptic vesicles
    Synaptic activity
    Swimming
    Stxbp1 protein, mouse
    Soleus neuromuscular-junctions
    Snap25 protein, human
    Skeletal-muscle
    Skeletal muscle
    Signal transduction
    Running
    Protein-tyrosine kinases
    Protein serine-threonine kinases
    Physical conditioning, animal
    Ntrk2 protein, mouse
    New activity conditions
    Neurotrophic factor
    Neuromuscular junction
    Nerve growth factors
    Muscle, skeletal
    Munc18 proteins
    Motor neurons
    Modulates acetylcholine-release
    Mitochondrial biogenesis
    Mice, inbred strains
    Mice
    Membrane glycoproteins
    Male
    Gene-expression
    Fast axonal-transport
    Endurance exercise
    C epsilon isoform
    Brain-derived neurotrophic factor
    Bdnf/trkb signaling
    Bdnf protein, mouse
    Bdnf
    Animals
    Zootecnia / recursos pesqueiros
    Spectroscopy
    Saúde coletiva
    Química
    Psicología
    Physical and theoretical chemistry
    Organic chemistry
    Odontología
    Nutrição
    Molecular biology
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    Inorganic chemistry
    Geociências
    Farmacia
    Engenharias iv
    Engenharias ii
    Engenharias i
    Educação física
    Computer science applications
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Ciência da computação
    Chemistry, multidisciplinary
    Catalysis
    Biotecnología
    Biodiversidade
    Biochemistry & molecular biology
    Astronomia / física
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