Author, as appears in the article.: Yue, Wen-Jun; Day, Craig S.; Martin, Ruben;
Department: Química Analítica i Química Orgànica
URV's Author/s: Day, Craig
Keywords: Site selectivity Site selective Secondary amides Saturated hydrocarbons Functionalization Bond activation Amides Alkylation
Abstract: A site-selective defluorinative sp(3) C-H alkylation of secondary amides that rapidly and reliably incorporates gemdifluoroalkene motifs into previously unfunctionalized sp(3) sites is disclosed. This protocol is distinguished by its mild conditions, wide scope, and exquisite site-selectivity, thus unlocking a new platform to introduce carbonyl isosteres at saturated hydrocarbon sites.
Thematic Areas: Química Materiais Interdisciplinar General chemistry Farmacia Engenharias iv Engenharias iii Engenharias ii Colloid and surface chemistry Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Chemistry, multidisciplinary Chemistry (miscellaneous) Chemistry (all) Chemistry Catalysis Biochemistry Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: craig.day@estudiants.urv.cat
Author identifier: 0000-0002-6931-0280
Record's date: 2024-07-27
Papper version: info:eu-repo/semantics/acceptedVersion
Link to the original source: https://pubs.acs.org/doi/10.1021/jacs.1c03126
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Journal Of The American Chemical Society. 143 (17): 6395-6400
APA: Yue, Wen-Jun; Day, Craig S.; Martin, Ruben; (2021). Site-Selective Defluorinative sp(3) C-H Alkylation of Secondary Amides. Journal Of The American Chemical Society, 143(17), 6395-6400. DOI: 10.1021/jacs.1c03126
Article's DOI: 10.1021/jacs.1c03126
Entity: Universitat Rovira i Virgili
Journal publication year: 2021
Publication Type: Journal Publications
Repositori URV