Articles producció científicaQuímica Analítica i Química Orgànica

Site-Selective Defluorinative sp(3) C-H Alkylation of Secondary Amides

  • Identification data

    Identifier:  imarina:9216332
    Handle: https://hdl.handle.net/20.500.11797/imarina9216332
    Authors:  Yue, Wen-Jun; Day, Craig S; Martin, Ruben
    Abstract:
    A site-selective defluorinative sp(3) C-H alkylation of secondary amides that rapidly and reliably incorporates gemdifluoroalkene motifs into previously unfunctionalized sp(3) sites is disclosed. This protocol is distinguished by its mild conditions, wide scope, and exquisite site-selectivity, thus unlocking a new platform to introduce carbonyl isosteres at saturated hydrocarbon sites.

  • Others:

    Link to the original source: https://pubs.acs.org/doi/10.1021/jacs.1c03126
    APA: Yue, Wen-Jun; Day, Craig S; Martin, Ruben (2021). Site-Selective Defluorinative sp(3) C-H Alkylation of Secondary Amides. Journal Of The American Chemical Society, 143(17), 6395-6400. DOI: 10.1021/jacs.1c03126
    Paper original source: Journal Of The American Chemical Society. 143 (17): 6395-6400
    Article's DOI: 10.1021/jacs.1c03126
    Journal publication year: 2021
    Entity: Universitat Rovira i Virgili
    Paper version: info:eu-repo/semantics/acceptedVersion
    Record's date: 2025-02-18
    URV's Author/s: Day, Craig
    Department: Química Analítica i Química Orgànica
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Publication Type: Journal Publications
    Author, as appears in the article.: Yue, Wen-Jun; Day, Craig S; Martin, Ruben
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Thematic Areas: Química, Materiais, Interdisciplinar, General chemistry, Farmacia, Engenharias iv, Engenharias iii, Engenharias ii, Colloid and surface chemistry, Ciências biológicas ii, Ciências biológicas i, Ciências agrárias i, Ciência de alimentos, Chemistry, multidisciplinary, Chemistry (miscellaneous), Chemistry (all), Chemistry, Catalysis, Biochemistry, Astronomia / física
    Author's mail: craig.day@estudiants.urv.cat

  • Keywords:

    Site selectivity
    Site selective
    Secondary amides
    Saturated hydrocarbons
    Functionalization
    Bond activation
    Amides
    Alkylation
    Biochemistry
    Catalysis
    Chemistry
    Chemistry (Miscellaneous)
    Multidisciplinary
    Colloid and Surface Chemistry
    Química
    Materiais
    Interdisciplinar
    General chemistry
    Farmacia
    Engenharias iv
    Engenharias iii
    Engenharias ii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência de alimentos
    Chemistry (all)
    Astronomia / física

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