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Site-Selective Defluorinative sp(3) C-H Alkylation of Secondary Amides

  • Datos identificativos

    Identificador: imarina:9216332
    Autores:
    Yue, Wen-JunDay, Craig S.Martin, Ruben
    Resumen:
    A site-selective defluorinative sp(3) C-H alkylation of secondary amides that rapidly and reliably incorporates gemdifluoroalkene motifs into previously unfunctionalized sp(3) sites is disclosed. This protocol is distinguished by its mild conditions, wide scope, and exquisite site-selectivity, thus unlocking a new platform to introduce carbonyl isosteres at saturated hydrocarbon sites.
  • Otros:

    Autor según el artículo: Yue, Wen-Jun; Day, Craig S.; Martin, Ruben;
    Departamento: Química Analítica i Química Orgànica
    Autor/es de la URV: Day, Craig
    Palabras clave: Site selectivity Site selective Secondary amides Saturated hydrocarbons Functionalization Bond activation Amides Alkylation
    Resumen: A site-selective defluorinative sp(3) C-H alkylation of secondary amides that rapidly and reliably incorporates gemdifluoroalkene motifs into previously unfunctionalized sp(3) sites is disclosed. This protocol is distinguished by its mild conditions, wide scope, and exquisite site-selectivity, thus unlocking a new platform to introduce carbonyl isosteres at saturated hydrocarbon sites.
    Áreas temáticas: Química Materiais Interdisciplinar General chemistry Farmacia Engenharias iv Engenharias iii Engenharias ii Colloid and surface chemistry Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Chemistry, multidisciplinary Chemistry (miscellaneous) Chemistry (all) Chemistry Catalysis Biochemistry Astronomia / física
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: craig.day@estudiants.urv.cat
    Identificador del autor: 0000-0002-6931-0280
    Fecha de alta del registro: 2024-07-27
    Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
    Enlace a la fuente original: https://pubs.acs.org/doi/10.1021/jacs.1c03126
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Journal Of The American Chemical Society. 143 (17): 6395-6400
    Referencia de l'ítem segons les normes APA: Yue, Wen-Jun; Day, Craig S.; Martin, Ruben; (2021). Site-Selective Defluorinative sp(3) C-H Alkylation of Secondary Amides. Journal Of The American Chemical Society, 143(17), 6395-6400. DOI: 10.1021/jacs.1c03126
    DOI del artículo: 10.1021/jacs.1c03126
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2021
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Biochemistry,Catalysis,Chemistry,Chemistry (Miscellaneous),Chemistry, Multidisciplinary,Colloid and Surface Chemistry
    Site selectivity
    Site selective
    Secondary amides
    Saturated hydrocarbons
    Functionalization
    Bond activation
    Amides
    Alkylation
    Química
    Materiais
    Interdisciplinar
    General chemistry
    Farmacia
    Engenharias iv
    Engenharias iii
    Engenharias ii
    Colloid and surface chemistry
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência de alimentos
    Chemistry, multidisciplinary
    Chemistry (miscellaneous)
    Chemistry (all)
    Chemistry
    Catalysis
    Biochemistry
    Astronomia / física
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