Author, as appears in the article.: Alexandra Iakab, Stefania; Rafols, Pere; Correig-Blanchar, Xavier; Garcia-Altares, Maria;

Department: Enginyeria Electrònica, Elèctrica i Automàtica

URV's Author/s: Ràfols Soler, Pere

Keywords: Vibrational spectroscopy Sweat Spatial resolution Scattering Research fields Multi-modal imaging Molecular information Mass spectrometry imaging (msi) Mass spectrometry Maldi-tof Lipidomics Imaging techniques Images Fusion Ft-ir Confocal raman microscopy Clinical application Biological samples Biological phenomena

Abstract: Studies on complex biological phenomena often combine two or more imaging techniques to collect high-quality comprehensive data directly in situ, preserving the biological context. Mass spectrometry imaging (MSI) and vibrational spectroscopy imaging (VSI) complement each other in terms of spatial resolution and molecular information. In the past decade, several combinations of such multimodal strategies arose in research fields as diverse as microbiology, cancer, and forensics, overcoming many challenges toward the unification of these techniques. Here we focus on presenting the advantages and challenges of multimodal imaging from the point of view of studying biological samples as well as giving a perspective on the upcoming trends regarding this topic. The latest efforts in the field are discussed, highlighting the purpose of the technique for clinical applications.

Thematic Areas: Química Medicina ii Medicina i Materiais Interdisciplinar Geociências General medicine Farmacia Ensino Engenharias iv Engenharias iii Engenharias ii Enfermagem Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Chemistry, analytical Biotecnología Biodiversidade Astronomia / física Analytical chemistry

licence for use: https://creativecommons.org/licenses/by/3.0/es/

Author's mail: pere.rafols@urv.cat

Author identifier: 0000-0002-9240-4058

Record's date: 2023-02-19

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://pubs.acs.org/doi/10.1021/acs.analchem.0c04986

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Analytical Chemistry. 93 (16): 6301-6310

APA: Alexandra Iakab, Stefania; Rafols, Pere; Correig-Blanchar, Xavier; Garcia-Altares, Maria; (2021). Perspective on Multimodal Imaging Techniques Coupling Mass Spectrometry and Vibrational Spectroscopy: Picturing the Best of Both Worlds. Analytical Chemistry, 93(16), 6301-6310. DOI: 10.1021/acs.analchem.0c04986

Article's DOI: 10.1021/acs.analchem.0c04986

Entity: Universitat Rovira i Virgili

Journal publication year: 2021

Publication Type: Journal Publications