Author, as appears in the article.: Mallafré-Muro, C; Llambrich, M; Cumeras, R; Pardo, A; Brezmes, J; Marco, S; Gumà, J
Department: Enginyeria Electrònica, Elèctrica i Automàtica
URV's Author/s: Cumeras Olmeda, Raquel / Gumà Padró, José / Llambrich Rodriguez, Maria
Keywords: Volatilomics Validation Urine Systematic review Nucleosides N-1,n-12-diacetylspermine Meta‐analysis Metabonomics Metabolomics Meta-analysis Markers Early-stage Diagnosis Colorectal cancer Chromatography Breast Biomarkers
Abstract: To increase compliance with colorectal cancer screening programs and to reduce the recommended screening age, cheaper and easy non‐invasiveness alternatives to the fecal immunochemical test should be provided. Following the PRISMA procedure of studies that evaluated the metabolome and volatilome signatures of colorectal cancer in human urine samples, an exhaustive search in PubMed, Web of Science, and Scopus found 28 studies that met the required criteria. There were no restrictions on the query for the type of study, leading to not only colorectal cancer samples versus control comparison but also polyps versus control and prospective studies of surgical effects, CRC staging and comparisons of CRC with other cancers. With this systematic review, we identified up to 244 compounds in urine samples (3 shared compounds between the volatilome and metabolome), and 10 of them were relevant in more than three articles. In the meta-analysis, nine studies met the criteria for inclusion, and the results combining the case‐control and the pre‐/post‐surgery groups, eleven compounds were found to be relevant. Four upregulated metabolites were identified, 3‐hydroxybutyric acid, L‐dopa, L‐histidinol, and N1, N12‐ diacetylspermine and seven downregulated compounds were identified, pyruvic acid, hydroquinone, tartaric acid, and hippuric acid as metabolites and butyraldehyde, ether, and 1,1,6‐ trimethyl‐1,2‐dihydronaphthalene as volatiles.
Thematic Areas: Oncology Medicina iii Cancer research
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: maria.llambrich@urv.cat raquel.cumeras@urv.cat maria.llambrich@urv.cat jose.guma@urv.cat
Author identifier: 0000-0001-8418-0982 0000-0003-4663-4247 0000-0001-8418-0982 0000-0001-7541-9832
Record's date: 2024-07-27
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.mdpi.com/2072-6694/13/11/2534
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Cancers. 13 (11): 2534-
APA: Mallafré-Muro, C; Llambrich, M; Cumeras, R; Pardo, A; Brezmes, J; Marco, S; Gumà, J (2021). Comprehensive volatilome and metabolome signatures of colorectal cancer in urine: A systematic review and meta‐analysis. Cancers, 13(11), 2534-. DOI: 10.3390/cancers13112534
Article's DOI: 10.3390/cancers13112534
Entity: Universitat Rovira i Virgili
Journal publication year: 2021
Publication Type: Journal Publications