Autor según el artículo: Mallafré‐muro C; Llambrich M; Cumeras R; Pardo A; Brezmes J; Marco S; Gumà J

Departamento: Enginyeria Electrònica, Elèctrica i Automàtica

Autor/es de la URV: Cumeras Olmeda, Raquel / Llambrich Rodriguez, Maria

Palabras clave: Volatilomics Validation Urine Systematic review Nucleosides N-1,n-12-diacetylspermine Meta‐analysis Metabonomics Metabolomics Meta-analysis Markers Early-stage Diagnosis Colorectal cancer Chromatography Breast Biomarkers

Resumen: To increase compliance with colorectal cancer screening programs and to reduce the recommended screening age, cheaper and easy non‐invasiveness alternatives to the fecal immunochemical test should be provided. Following the PRISMA procedure of studies that evaluated the metabolome and volatilome signatures of colorectal cancer in human urine samples, an exhaustive search in PubMed, Web of Science, and Scopus found 28 studies that met the required criteria. There were no restrictions on the query for the type of study, leading to not only colorectal cancer samples versus control comparison but also polyps versus control and prospective studies of surgical effects, CRC staging and comparisons of CRC with other cancers. With this systematic review, we identified up to 244 compounds in urine samples (3 shared compounds between the volatilome and metabolome), and 10 of them were relevant in more than three articles. In the meta-analysis, nine studies met the criteria for inclusion, and the results combining the case‐control and the pre‐/post‐surgery groups, eleven compounds were found to be relevant. Four upregulated metabolites were identified, 3‐hydroxybutyric acid, L‐dopa, L‐histidinol, and N1, N12‐ diacetylspermine and seven downregulated compounds were identified, pyruvic acid, hydroquinone, tartaric acid, and hippuric acid as metabolites and butyraldehyde, ether, and 1,1,6‐ trimethyl‐1,2‐dihydronaphthalene as volatiles.

Áreas temáticas: Oncology Medicina iii Cancer research

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

Direcció de correo del autor: raquel.cumeras@urv.cat maria.llambrich@urv.cat

Identificador del autor: 0000-0003-4663-4247

Fecha de alta del registro: 2023-02-19

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Enlace a la fuente original: https://www.mdpi.com/2072-6694/13/11/2534

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Cancers. 13 (11):

Referencia de l'ítem segons les normes APA: Mallafré‐muro C; Llambrich M; Cumeras R; Pardo A; Brezmes J; Marco S; Gumà J (2021). Comprehensive volatilome and metabolome signatures of colorectal cancer in urine: A systematic review and meta‐analysis. Cancers, 13(11), -. DOI: 10.3390/cancers13112534

DOI del artículo: 10.3390/cancers13112534

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2021

Tipo de publicación: Journal Publications