Articles producció científica> Bioquímica i Biotecnologia

Circulating vitamin D levels and colorectal cancer risk: A meta-analysis and systematic review of case-control and prospective cohort studies

  • Identification data

    Identifier: imarina:9223784
    Authors:
    Hernandez-Alonso, PabloBoughanem, HatimCanudas, SilviaBecerra-Tomas, Nereade la Puente, Maria FernandezBabio, NancyMacias-Gonzalez, ManuelSalas-Salvado, Jordi
    Abstract:
    The associations between circulating vitamin D concentrations and total and site-specific colorectal cancer (CRC) incidence have been examined in several epidemiological studies with overall inconclusive findings. The aim of this systematic review and meta-analysis of both case-control and prospective cohort studies was to evaluate the association between CRC and circulating levels of vitamin D. The main exposure and outcome were circulating total 25(OH)D and CRC, respectively, in the overall population (i.e., all subjects). Two reviewers, working independently, screened all the literature available to identify studies that met the inclusion criteria (e.g., case-control or prospective cohort studies, published in English, and excluding non-original papers). Data were pooled by the generic inverse variance method using a random or fixed effect model, as approriate. Heterogeneity was identified using the Cochran's Q-test and quantified by the I-2 statistic. Results were stratified by study design, sex, and metabolite of vitamin D. Sensitivity and subgroup analyses were also performed. A total of 28 original studies were included for the quantitative meta-analysis. Meta-analyses comparing the highest vs lowest categories, showed a 39% lower risk between levels of total 25(OH)D and CRC risk (OR (95% CI): 0.61 (0.52; 0.71); 11 studies) in case-control studies; whereas a 20% reduced CRC risk in prospective cohort studies (HR (95% CI): 0.80 (0.66; 0.97); 6 studies). Results in women mirrored main results, whereas results in men were non-significant in both analyses. Our findings support an inverse association between circulating vitamin D levels and CRC risk.
  • Others:

    Author, as appears in the article.: Hernandez-Alonso, Pablo; Boughanem, Hatim; Canudas, Silvia; Becerra-Tomas, Nerea; de la Puente, Maria Fernandez; Babio, Nancy; Macias-Gonzalez, Manuel; Salas-Salvado, Jordi;
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Babio Sánchez, Nancy Elvira / Becerra Tomás, Nerea / Salas Salvadó, Jorge
    Keywords: Vitamin d Systematic review Serum 25-hydroxyvitamin d Rectal-cancer Rectal cancer Prostate Meta-analysis Lung Health D-binding protein D metabolites Colorectal cancer Colon-cancer Colon cancer Breast Association
    Abstract: The associations between circulating vitamin D concentrations and total and site-specific colorectal cancer (CRC) incidence have been examined in several epidemiological studies with overall inconclusive findings. The aim of this systematic review and meta-analysis of both case-control and prospective cohort studies was to evaluate the association between CRC and circulating levels of vitamin D. The main exposure and outcome were circulating total 25(OH)D and CRC, respectively, in the overall population (i.e., all subjects). Two reviewers, working independently, screened all the literature available to identify studies that met the inclusion criteria (e.g., case-control or prospective cohort studies, published in English, and excluding non-original papers). Data were pooled by the generic inverse variance method using a random or fixed effect model, as approriate. Heterogeneity was identified using the Cochran's Q-test and quantified by the I-2 statistic. Results were stratified by study design, sex, and metabolite of vitamin D. Sensitivity and subgroup analyses were also performed. A total of 28 original studies were included for the quantitative meta-analysis. Meta-analyses comparing the highest vs lowest categories, showed a 39% lower risk between levels of total 25(OH)D and CRC risk (OR (95% CI): 0.61 (0.52; 0.71); 11 studies) in case-control studies; whereas a 20% reduced CRC risk in prospective cohort studies (HR (95% CI): 0.80 (0.66; 0.97); 6 studies). Results in women mirrored main results, whereas results in men were non-significant in both analyses. Our findings support an inverse association between circulating vitamin D levels and CRC risk.
    Thematic Areas: Saúde coletiva Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina ii Medicina i Interdisciplinar Industrial and manufacturing engineering General medicine Food science & technology Food science Farmacia Engenharias iii Engenharias ii Ciências biológicas iii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: nerea.becerra@urv.cat jordi.salas@urv.cat nancy.babio@urv.cat
    Author identifier: 0000-0002-4429-6507 0000-0003-2700-7459 0000-0003-3527-5277
    Record's date: 2024-08-03
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.tandfonline.com/doi/full/10.1080/10408398.2021.1939649
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Critical Reviews In Food Science And Nutrition. 63 (1): 1-17
    APA: Hernandez-Alonso, Pablo; Boughanem, Hatim; Canudas, Silvia; Becerra-Tomas, Nerea; de la Puente, Maria Fernandez; Babio, Nancy; Macias-Gonzalez, Manuel (2023). Circulating vitamin D levels and colorectal cancer risk: A meta-analysis and systematic review of case-control and prospective cohort studies. Critical Reviews In Food Science And Nutrition, 63(1), 1-17. DOI: 10.1080/10408398.2021.1939649
    Article's DOI: 10.1080/10408398.2021.1939649
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2023
    Publication Type: Journal Publications
  • Keywords:

    Food Science,Food Science & Technology,Industrial and Manufacturing Engineering,Medicine (Miscellaneous),Nutrition & Dietetics
    Vitamin d
    Systematic review
    Serum 25-hydroxyvitamin d
    Rectal-cancer
    Rectal cancer
    Prostate
    Meta-analysis
    Lung
    Health
    D-binding protein
    D metabolites
    Colorectal cancer
    Colon-cancer
    Colon cancer
    Breast
    Association
    Saúde coletiva
    Nutrition & dietetics
    Nutrição
    Medicine (miscellaneous)
    Medicina ii
    Medicina i
    Interdisciplinar
    Industrial and manufacturing engineering
    General medicine
    Food science & technology
    Food science
    Farmacia
    Engenharias iii
    Engenharias ii
    Ciências biológicas iii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
  • Documents:

  • Cerca a google

    Search to google scholar