Author, as appears in the article.: Alexandra Iakab, Stefania; Rafols, Pere; Garcia-Altares, Maria; Yanes, Oscar; Correig, Xavier
Department: Enginyeria Electrònica, Elèctrica i Automàtica
URV's Author/s: Correig Blanchar, Francesc Xavier / Garcia-Altares Pérez, Maria / Ràfols Soler, Pere / Yanes Torrado, Óscar
Keywords: Surface functionalization Silver nanoparticles Silicon nanostructures Selective enrichment Nanowire arrays Nanostructure Ms analysis Modified porous silicon Mass spectrometry imaging (msi) Maldi Laser desorption ionization (ldi) Ion formation High-sensitivity Desorption/ionization
Abstract: Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) is widely used in the biomedical field for the label-free analysis of molecules such as drugs, lipids, peptides, proteins, and biological tissues for molecular imaging. However, organic matrices used in traditional MALDI-MS applications introduce excessive interferences in the low m/z range. For this reason, nanostructured materials-and in particular silicon-based LDI strategies-have become a promising alternative, since they provide a much weaker background. Herein, the recent developments in fabrication, functionalization, and practical applications of silicon-based LDI-MS methods are reviewed. Also the basic requirements of silicon-based substrates for optimal LDI analysis by providing an overview of the LDI mechanisms that use silicon-based substrates instead of organic matrices are reported. Finally, the considerable potential of silicon-based substrates is discussed, giving suggestions for topics for future research.
Thematic Areas: Química Physics, condensed matter Physics, applied Nanoscience and nanotechnology Nanoscience & nanotechnology Materials science, multidisciplinary Materials science (miscellaneous) Materials science (all) Materiais General materials science General chemistry Engenharias iv Engenharias ii Electronic, optical and magnetic materials Electrochemistry Condensed matter physics Ciências agrárias i Chemistry, physical Chemistry, multidisciplinary Chemistry (miscellaneous) Chemistry (all) Biomaterials Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: oscar.yanes@urv.cat maria.garcia-altares@urv.cat pere.rafols@urv.cat xavier.correig@urv.cat
Author identifier: 0000-0003-3695-7157 0000-0002-9240-4058 0000-0002-6902-3054
Record's date: 2024-10-12
Papper version: info:eu-repo/semantics/acceptedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Advanced Functional Materials. 29 (45): 1903609-
APA: Alexandra Iakab, Stefania; Rafols, Pere; Garcia-Altares, Maria; Yanes, Oscar; Correig, Xavier (2019). Silicon-Based Laser Desorption Ionization Mass Spectrometry for the Analysis of Biomolecules: A Progress Report. Advanced Functional Materials, 29(45), 1903609-. DOI: 10.1002/adfm.201903609
Entity: Universitat Rovira i Virgili
Journal publication year: 2019
Publication Type: Journal Publications
Repositori URV