Author, as appears in the article.: Malo, AI; Peraire, J; Ruiz-Mateos, E; Masip, J; Amigó, N; Alcamí, J; Moreno, S; Girona, J; García-Pardo, G; Reig, R; Vidal, F; Castro, A; Masana, L; Rull, A
Department: Medicina i Cirurgia Ciències Mèdiques Bàsiques
URV's Author/s: Castro Salomó, Antoni / Girona Tell, Josefa / Masana Marín, Luis / Masip Morcillo, Jenifer / Peraire Forner, José Joaquin / RULL AIXA, ANNA
Keywords: Replication Proton nuclear magnetic resonance Proteins Mechanisms Inflammation Hiv Glycosylation Glyca Events Elite controllers Biomarkers Acute-phase glycoproteins
Abstract: Elite controllers (ECs) are an exceptional group of people living with HIV (PLWH) who maintain undetectable viral loads (VLs) despite not being on antiretroviral therapy (ART). However, this phenotype is heterogeneous, with some of these subjects losing virological control over time. In this longitudinal retrospective study, serum acute-phase glycoprotein profile assessed by proton nuclear magnetic resonance (H-1-NMR) was determined in 11 transient controllers (TCs) who spontaneously lost virological control and 11 persistent controllers (PCs) who persistently maintained virological control over time. Both PCs and TCs showed similar acute-phase glycoprotein profiles, even when TCs lost the virological control (GlycB, p = 0.824 and GlycA, p = 0.710), and the serum acute-phase glycoprotein signature in PCs did not differ from that in HIV-negative subjects (GlycB, p = 0.151 and GlycA, p = 0.243). Differences in serum glycoproteins A and B were significant only in ECs compared to HIV-typical progressors (TPs) with < 100 CD4+ T-cells (p < 0.001). H-1-NMR acute-phase glycoprotein profile does not distinguish TCs form PCs before the loss of viral control. ECs maintain a low-grade inflammatory state compared to TPs. PCs revealed a closer serum signature to HIV-negative subjects, reaffirming this phenotype as a closer model of functional control of HIV.</p>
Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Odontología Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Immunology and allergy Immunology Farmacia Engenharias iii Engenharias ii Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Biotecnología Biodiversidade
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: luis.masana@urv.cat josefa.girona@urv.cat joaquim.peraire@urv.cat jenifer.masip@estudiants.urv.cat jenifer.masip@estudiants.urv.cat josefa.girona@urv.cat antoni.castro@urv.cat
Author identifier: 0000-0002-0789-4954 0000-0002-6267-8779 0000-0001-7808-5479 0000-0002-6267-8779 0000-0001-5441-6333
Record's date: 2024-07-27
Papper version: info:eu-repo/semantics/publishedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Frontiers In Immunology. 12
APA: Malo, AI; Peraire, J; Ruiz-Mateos, E; Masip, J; Amigó, N; Alcamí, J; Moreno, S; Girona, J; García-Pardo, G; Reig, R; Vidal, F; Castro, A; Masana, L; R (2021). Evolution of Serum Acute-Phase Glycoproteins Assessed by H-1-NMR in HIV Elite Controllers. Frontiers In Immunology, 12(), -. DOI: 10.3389/fimmu.2021.730691
Entity: Universitat Rovira i Virgili
Journal publication year: 2021
Publication Type: Journal Publications