Articles producció científica> Medicina i Cirurgia

Evolution of Serum Acute-Phase Glycoproteins Assessed by H-1-NMR in HIV Elite Controllers

  • Datos identificativos

    Identificador: imarina:9230373
    Autores:
    Malo, AIPeraire, JRuiz-Mateos, EMasip, JAmigó, NAlcamí, JMoreno, SGirona, JGarcía-Pardo, GReig, RVidal, FCastro, AMasana, LRull, A
    Resumen:
    Elite controllers (ECs) are an exceptional group of people living with HIV (PLWH) who maintain undetectable viral loads (VLs) despite not being on antiretroviral therapy (ART). However, this phenotype is heterogeneous, with some of these subjects losing virological control over time. In this longitudinal retrospective study, serum acute-phase glycoprotein profile assessed by proton nuclear magnetic resonance (H-1-NMR) was determined in 11 transient controllers (TCs) who spontaneously lost virological control and 11 persistent controllers (PCs) who persistently maintained virological control over time. Both PCs and TCs showed similar acute-phase glycoprotein profiles, even when TCs lost the virological control (GlycB, p = 0.824 and GlycA, p = 0.710), and the serum acute-phase glycoprotein signature in PCs did not differ from that in HIV-negative subjects (GlycB, p = 0.151 and GlycA, p = 0.243). Differences in serum glycoproteins A and B were significant only in ECs compared to HIV-typical progressors (TPs) with < 100 CD4+ T-cells (p < 0.001). H-1-NMR acute-phase glycoprotein profile does not distinguish TCs form PCs before the loss of viral control. ECs maintain a low-grade inflammatory state compared to TPs. PCs revealed a closer serum signature to HIV-negative subjects, reaffirming this phenotype as a closer model of functional control of HIV.

  • Otros:

    Autor según el artículo: Malo, AI; Peraire, J; Ruiz-Mateos, E; Masip, J; Amigó, N; Alcamí, J; Moreno, S; Girona, J; García-Pardo, G; Reig, R; Vidal, F; Castro, A; Masana, L; Rull, A
    Departamento: Medicina i Cirurgia Ciències Mèdiques Bàsiques
    Autor/es de la URV: Castro Salomó, Antoni / Girona Tell, Josefa / Masana Marín, Luis / Masip Morcillo, Jenifer / Peraire Forner, José Joaquin / RULL AIXA, ANNA
    Palabras clave: Replication Proton nuclear magnetic resonance Proteins Mechanisms Inflammation Hiv Glycosylation Glyca Events Elite controllers Biomarkers Acute-phase glycoproteins
    Resumen: Elite controllers (ECs) are an exceptional group of people living with HIV (PLWH) who maintain undetectable viral loads (VLs) despite not being on antiretroviral therapy (ART). However, this phenotype is heterogeneous, with some of these subjects losing virological control over time. In this longitudinal retrospective study, serum acute-phase glycoprotein profile assessed by proton nuclear magnetic resonance (H-1-NMR) was determined in 11 transient controllers (TCs) who spontaneously lost virological control and 11 persistent controllers (PCs) who persistently maintained virological control over time. Both PCs and TCs showed similar acute-phase glycoprotein profiles, even when TCs lost the virological control (GlycB, p = 0.824 and GlycA, p = 0.710), and the serum acute-phase glycoprotein signature in PCs did not differ from that in HIV-negative subjects (GlycB, p = 0.151 and GlycA, p = 0.243). Differences in serum glycoproteins A and B were significant only in ECs compared to HIV-typical progressors (TPs) with < 100 CD4+ T-cells (p < 0.001). H-1-NMR acute-phase glycoprotein profile does not distinguish TCs form PCs before the loss of viral control. ECs maintain a low-grade inflammatory state compared to TPs. PCs revealed a closer serum signature to HIV-negative subjects, reaffirming this phenotype as a closer model of functional control of HIV.</p>
    Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Química Odontología Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Immunology and allergy Immunology Farmacia Engenharias iii Engenharias ii Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Biotecnología Biodiversidade
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: luis.masana@urv.cat josefa.girona@urv.cat joaquim.peraire@urv.cat jenifer.masip@estudiants.urv.cat jenifer.masip@estudiants.urv.cat josefa.girona@urv.cat antoni.castro@urv.cat
    Identificador del autor: 0000-0002-0789-4954 0000-0002-6267-8779 0000-0001-7808-5479 0000-0002-6267-8779 0000-0001-5441-6333
    Fecha de alta del registro: 2024-07-27
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://www.frontiersin.org/articles/10.3389/fimmu.2021.730691/full
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Frontiers In Immunology. 12
    Referencia de l'ítem segons les normes APA: Malo, AI; Peraire, J; Ruiz-Mateos, E; Masip, J; Amigó, N; Alcamí, J; Moreno, S; Girona, J; García-Pardo, G; Reig, R; Vidal, F; Castro, A; Masana, L; R (2021). Evolution of Serum Acute-Phase Glycoproteins Assessed by H-1-NMR in HIV Elite Controllers. Frontiers In Immunology, 12(), -. DOI: 10.3389/fimmu.2021.730691
    DOI del artículo: 10.3389/fimmu.2021.730691
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2021
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Immunology,Immunology and Allergy
    Replication
    Proton nuclear magnetic resonance
    Proteins
    Mechanisms
    Inflammation
    Hiv
    Glycosylation
    Glyca
    Events
    Elite controllers
    Biomarkers
    Acute-phase glycoproteins
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Odontología
    Nutrição
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Immunology and allergy
    Immunology
    Farmacia
    Engenharias iii
    Engenharias ii
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciência de alimentos
    Biotecnología
    Biodiversidade
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