Articles producció científica> Química Física i Inorgànica

Optofluidic device for the quantification of circulating tumor cells in breast cancer

  • Identification data

    Identifier: imarina:9242026
    Authors:
    Pedrol, EricGarcia-Algar, ManuelMassons, JaumeNazarenus, MoritzGuerrini, LucaMartinez, JavierRodenas, AiranFernandez-Carrascal, AnaAguilo, MagdalenaEstevez, Laura GCalvo, IsabelOlano-Daza, AnaGarcia-Rico, EduardoDiaz, FrancescAlvarez-Puebla, Ramon A
    Abstract:
    Metastatic cancer patients require a continuous monitoring during the sequential treatment cycles to carefully evaluate their disease evolution. Repetition of biopsies is very invasive and not always feasible. Herein, we design and demonstrate a 3D-flow focusing microfluidic device, where all optics are integrated into the chip, for the fluorescence quantification of CTCs in real samples. To test the chip performance, two cell membrane targets, the epithelial cell adhesion molecule, EpCAM, and the receptor tyrosine-protein kinase, HER2, are selected. The efficiency of the platform
  • Others:

    Author, as appears in the article.: Pedrol, Eric; Garcia-Algar, Manuel; Massons, Jaume; Nazarenus, Moritz; Guerrini, Luca; Martinez, Javier; Rodenas, Airan; Fernandez-Carrascal, Ana; Aguilo, Magdalena; Estevez, Laura G; Calvo, Isabel; Olano-Daza, Ana; Garcia-Rico, Eduardo; Diaz, Francesc; Alvarez-Puebla, Ramon A
    Department: Química Física i Inorgànica
    URV's Author/s: Aguiló Díaz, Magdalena / Alvarez Puebla, Ramon Angel / Díaz González, Francisco Manuel / Guerrini, Luca / Masons Bosch, Jaime / RODENAS SEGUI, AIRAN
    Keywords: Samples Microfluidics Level Kinase inhibitor Her2 Expression Està en blanc Embedded microchips Egfr Capture
    Abstract: Metastatic cancer patients require a continuous monitoring during the sequential treatment cycles to carefully evaluate their disease evolution. Repetition of biopsies is very invasive and not always feasible. Herein, we design and demonstrate a 3D-flow focusing microfluidic device, where all optics are integrated into the chip, for the fluorescence quantification of CTCs in real samples. To test the chip performance, two cell membrane targets, the epithelial cell adhesion molecule, EpCAM, and the receptor tyrosine-protein kinase, HER2, are selected. The efficiency of the platform
    Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Odontología Nutrição Multidisciplinary sciences Multidisciplinary Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Letras / linguística Interdisciplinar Geografía Geociências Farmacia Engenharias iv Engenharias iii Engenharias ii Enfermagem Educação física Educação Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Biotecnología Biodiversidade Astronomia / física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: ramon.alvarez@urv.cat luca.guerrini@urv.cat magdalena.aguilo@urv.cat jaume.masons@urv.cat f.diaz@urv.cat
    Author identifier: 0000-0003-4770-5756 0000-0002-2925-1562 0000-0001-6130-9579 0000-0003-4325-6084 0000-0003-4581-4967
    Record's date: 2024-10-19
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.nature.com/articles/s41598-017-04033-9
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Scientific Reports. 7 (1): 3677-
    APA: Pedrol, Eric; Garcia-Algar, Manuel; Massons, Jaume; Nazarenus, Moritz; Guerrini, Luca; Martinez, Javier; Rodenas, Airan; Fernandez-Carrascal, Ana; Agu (2017). Optofluidic device for the quantification of circulating tumor cells in breast cancer. Scientific Reports, 7(1), 3677-. DOI: 10.1038/s41598-017-04033-9
    Article's DOI: 10.1038/s41598-017-04033-9
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2017
    Publication Type: Journal Publications
  • Keywords:

    Multidisciplinary,Multidisciplinary Sciences
    Samples
    Microfluidics
    Level
    Kinase inhibitor
    Her2
    Expression
    Està en blanc
    Embedded microchips
    Egfr
    Capture
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Psicología
    Odontología
    Nutrição
    Multidisciplinary sciences
    Multidisciplinary
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Matemática / probabilidade e estatística
    Letras / linguística
    Interdisciplinar
    Geografía
    Geociências
    Farmacia
    Engenharias iv
    Engenharias iii
    Engenharias ii
    Enfermagem
    Educação física
    Educação
    Economia
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Ciência da computação
    Biotecnología
    Biodiversidade
    Astronomia / física
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