Author, as appears in the article.: Pedrol, Eric; Garcia-Algar, Manuel; Massons, Jaume; Nazarenus, Moritz; Guerrini, Luca; Martinez, Javier; Rodenas, Airan; Fernandez-Carrascal, Ana; Aguilo, Magdalena; Estevez, Laura G; Calvo, Isabel; Olano-Daza, Ana; Garcia-Rico, Eduardo; Diaz, Francesc; Alvarez-Puebla, Ramon A
Department: Química Física i Inorgànica
URV's Author/s: Aguiló Díaz, Magdalena / Alvarez Puebla, Ramon Angel / Díaz González, Francisco Manuel / Guerrini, Luca / Masons Bosch, Jaime / RODENAS SEGUI, AIRAN
Keywords: Samples Neoplastic cells, circulating Neoplasm metastasis Middle aged Microfluidics Microfluidic analytical techniques Magnetic resonance imaging Level Lab-on-a-chip devices Kinase inhibitor Humans Her2 Fluorescent antibody technique Female Expression Està en blanc Embedded microchips Egfr Disease progression Cell line, tumor Case-control studies Capture Breast neoplasms Biomarkers, tumor Biomarkers Aged Adult
Abstract: Metastatic cancer patients require a continuous monitoring during the sequential treatment cycles to carefully evaluate their disease evolution. Repetition of biopsies is very invasive and not always feasible. Herein, we design and demonstrate a 3D-flow focusing microfluidic device, where all optics are integrated into the chip, for the fluorescence quantification of CTCs in real samples. To test the chip performance, two cell membrane targets, the epithelial cell adhesion molecule, EpCAM, and the receptor tyrosine-protein kinase, HER2, are selected. The efficiency of the platform
Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Odontología Nutrição Multidisciplinary sciences Multidisciplinary Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Letras / linguística Interdisciplinar Geografía Geociências Farmacia Engenharias iv Engenharias iii Engenharias ii Enfermagem Educação física Educação Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Biotecnología Biodiversidade Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: ramon.alvarez@urv.cat luca.guerrini@urv.cat magdalena.aguilo@urv.cat jaume.masons@urv.cat f.diaz@urv.cat
Author identifier: 0000-0003-4770-5756 0000-0002-2925-1562 0000-0001-6130-9579 0000-0003-4325-6084 0000-0003-4581-4967
Record's date: 2025-02-19
Paper version: info:eu-repo/semantics/publishedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Paper original source: Scientific Reports. 7 (1): 3677-
APA: Pedrol, Eric; Garcia-Algar, Manuel; Massons, Jaume; Nazarenus, Moritz; Guerrini, Luca; Martinez, Javier; Rodenas, Airan; Fernandez-Carrascal, Ana; Agu (2017). Optofluidic device for the quantification of circulating tumor cells in breast cancer. Scientific Reports, 7(1), 3677-. DOI: 10.1038/s41598-017-04033-9
Entity: Universitat Rovira i Virgili
Journal publication year: 2017
Publication Type: Journal Publications
Repositori URV