Author, as appears in the article.: Antonelli F; Casciati A; Belles M; Serra N; Linares Vidal MV; Marino C; Mancuso M; Pazzaglia S
Department: Ciències Mèdiques Bàsiques
URV's Author/s: Bellés Mateu, Montserrat / Linares Vidal, M. Victoria / Serra Encinas, Noemi
Keywords: Ionizing radiation Hippocampal neurogenesis Cognitive effects Astrocytes
Abstract: Radiation therapy represents one of the primary treatment modalities for primary and metastatic brain tumors. Although recent advances in radiation techniques, that allow the delivery of higher radiation doses to the target volume, reduce the toxicity to normal tissues, long?term neurocognitive decline is still a detrimental factor significantly affecting quality of life, particularly in pediatric patients. This imposes the need for the development of prevention strategies. Based on recent evidence, showing that manipulation of the Shh pathway carries therapeutic potential for brain repair and functional recovery after injury, here we evaluate how radiation?induced hippocampal alterations are modulated by the constitutive activation of the Shh signaling pathway in Patched 1 heterozygous mice (Ptch1+/?). Our results show, for the first time, an overall protective effect of constitutive Shh pathway activation on hippocampal radiation injury. This activation, through modulation of the proneural gene network, leads to a long?term reduction of hippocampal deficits in the stem cell and new neuron compartments and to the mitigation of radio?induced astrogliosis, despite some behavioral alterations still being detected in Ptch1+/? mice. A better understanding of the pathogenic mechanisms responsible for the neural decline following irradiation is essential for identifying prevention measures to contain the harmful consequences of irradiation. Our data have important translational implications as they suggest a role for Shh pathway manipulation to provide the therapeutic possibility of improving brain repair and functional recovery after radio?induced injury. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Thematic Areas: Zootecnia / recursos pesqueiros Spectroscopy Saúde coletiva Química Psicología Physical and theoretical chemistry Organic chemistry Odontología Nutrição Molecular biology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Inorganic chemistry Geociências Farmacia Engenharias iv Engenharias ii Engenharias i Educação física Computer science applications Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Chemistry, multidisciplinary Catalysis Biotecnología Biodiversidade Biochemistry & molecular biology Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: montserrat.belles@urv.cat mvictoria.linares@urv.cat noemi.serra@urv.cat
Author identifier: 0000-0002-9282-2989 0000-0003-4170-4197 0000-0002-2277-351X
Record's date: 2024-06-22
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.mdpi.com/1422-0067/22/22/12605
Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: International Journal Of Molecular Sciences. 22 (22):
APA: Antonelli F; Casciati A; Belles M; Serra N; Linares Vidal MV; Marino C; Mancuso M; Pazzaglia S (2021). Long-term effects of ionizing radiation on the hippocampus: Linking effects of the sonic hedgehog pathway activation with radiation response. International Journal Of Molecular Sciences, 22(22), -. DOI: 10.3390/ijms222212605
Article's DOI: 10.3390/ijms222212605
Entity: Universitat Rovira i Virgili
Journal publication year: 2021
Publication Type: Journal Publications
Repositori URV