Author, as appears in the article.: Catalán, Úrsula; Pedret, Anna; Yuste, Silvia; Rubió, Laura; Piñol, Carme; Sandoval-Ramírez, Berner Andrée; Companys, Judit; Foguet, Elisabet; Herrero, Pol; Canela, Núria; Motilva, Maria-Jose; Solà, Rosa
Department: Medicina i Cirurgia
URV's Author/s: Catalán Santos, Úrsula / Companys Alemany, Judit / HERRERO GIL, POL / Pedret Figuerola, Anna / SANDOVAL RAMÍREZ, BERNER ANDRÉE / Solà Alberich, Rosa Maria
Keywords: Proteomics Phenolic compounds Cyclase-associated protein-1 Apples Aorta and heart rat tissues Anthocyanins serum ferritin risk proteomics physical-activity phenolic-compounds phenolic compounds overexpression inflammation components ceruloplasmin c-reactive protein apples aorta and heart rat tissues
Abstract: The impact of a red-fleshed apple (RFA) rich in anthocyanins (ACNs), a white-fleshed apple (WFA) without ACNs, and an extract infusion from Aronia fruit (AI) equivalent in dose of cyanidin-3-O-galactoside (main ACN) as RFA was determined by the proteome profile of aorta and heart as key cardiovascular tissues. Hypercholesterolaemic Wistar rats were separated into six groups (n = 6/group; three males and three females) and the proteomic profiles were analyzed using nanoliquid chromatography coupled to mass spectrometry. No adverse events were reported and all products were well tolerated. RFA downregulated C1QB and CFP in aorta and CRP in heart. WFA downregulated C1QB and CFP in aorta and C9 and C3 in aorta and heart, among other proteins. AI downregulated PRKACA, IQGAP1, and HSP90AB1 related to cellular signaling. Thus, both apples showed an anti-inflammatory effect through the complement system, while RFA reduced CRP. Regardless of the ACN content, an apple matrix effect was observed that involved different bioactive components, and inflammatory proteins were reduced.
Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: judit.companys@urv.cat ursula.catalan@urv.cat anna.pedret@urv.cat judit.companys@urv.cat judit.companys@urv.cat rosa.sola@urv.cat
Author identifier: 0000-0003-1485-0818 0000-0001-8884-9823 0000-0002-5327-932X 0000-0003-1485-0818 0000-0003-1485-0818 0000-0002-8359-235X
Record's date: 2024-09-07
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.mdpi.com/2072-6643/14/5/1047
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Nutrients. 14 (5): 1047-
APA: Catalán, Úrsula; Pedret, Anna; Yuste, Silvia; Rubió, Laura; Piñol, Carme; Sandoval-Ramírez, Berner Andrée; Companys, Judit; Foguet, Elisabet; Herrero, (2022). Red-Fleshed Apples Rich in Anthocyanins and White-Fleshed Apples Modulate the Aorta and Feart Proteome in Hypercholesterolaemic Rats. The AppleCOR Study. Nutrients, 14(5), 1047-. DOI: 10.3390/nu14051047
Article's DOI: 10.3390/nu14051047
Entity: Universitat Rovira i Virgili
Journal publication year: 2022
Publication Type: Journal Publications
Repositori URV