Autor según el artículo: Catalán, Úrsula; Pedret, Anna; Yuste, Silvia; Rubió, Laura; Piñol, Carme; Sandoval-Ramírez, Berner Andrée; Companys, Judit; Foguet, Elisabet; Herrero, Pol; Canela, Núria; Motilva, Maria-Jose; Solà, Rosa
Departamento: Medicina i Cirurgia
Autor/es de la URV: Catalán Santos, Úrsula / Companys Alemany, Judit / HERRERO GIL, POL / Pedret Figuerola, Anna / SANDOVAL RAMÍREZ, BERNER ANDRÉE / Solà Alberich, Rosa Maria
Palabras clave: Proteomics Phenolic compounds Cyclase-associated protein-1 Apples Aorta and heart rat tissues Anthocyanins serum ferritin risk proteomics physical-activity phenolic-compounds phenolic compounds overexpression inflammation components ceruloplasmin c-reactive protein apples aorta and heart rat tissues
Resumen: The impact of a red-fleshed apple (RFA) rich in anthocyanins (ACNs), a white-fleshed apple (WFA) without ACNs, and an extract infusion from Aronia fruit (AI) equivalent in dose of cyanidin-3-O-galactoside (main ACN) as RFA was determined by the proteome profile of aorta and heart as key cardiovascular tissues. Hypercholesterolaemic Wistar rats were separated into six groups (n = 6/group; three males and three females) and the proteomic profiles were analyzed using nanoliquid chromatography coupled to mass spectrometry. No adverse events were reported and all products were well tolerated. RFA downregulated C1QB and CFP in aorta and CRP in heart. WFA downregulated C1QB and CFP in aorta and C9 and C3 in aorta and heart, among other proteins. AI downregulated PRKACA, IQGAP1, and HSP90AB1 related to cellular signaling. Thus, both apples showed an anti-inflammatory effect through the complement system, while RFA reduced CRP. Regardless of the ACN content, an apple matrix effect was observed that involved different bioactive components, and inflammatory proteins were reduced.
Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: judit.companys@urv.cat ursula.catalan@urv.cat anna.pedret@urv.cat judit.companys@urv.cat judit.companys@urv.cat rosa.sola@urv.cat
Identificador del autor: 0000-0003-1485-0818 0000-0001-8884-9823 0000-0002-5327-932X 0000-0003-1485-0818 0000-0003-1485-0818 0000-0002-8359-235X
Fecha de alta del registro: 2024-09-07
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.mdpi.com/2072-6643/14/5/1047
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Nutrients. 14 (5): 1047-
Referencia de l'ítem segons les normes APA: Catalán, Úrsula; Pedret, Anna; Yuste, Silvia; Rubió, Laura; Piñol, Carme; Sandoval-Ramírez, Berner Andrée; Companys, Judit; Foguet, Elisabet; Herrero, (2022). Red-Fleshed Apples Rich in Anthocyanins and White-Fleshed Apples Modulate the Aorta and Feart Proteome in Hypercholesterolaemic Rats. The AppleCOR Study. Nutrients, 14(5), 1047-. DOI: 10.3390/nu14051047
DOI del artículo: 10.3390/nu14051047
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2022
Tipo de publicación: Journal Publications
Repositori URV