Articles producció científica> Bioquímica i Biotecnologia

Adherence to the Mediterranean Diet Has a Protective Role against Metabolic and DNA Damage Markers in Colorectal Cancer Patients

  • Identification data

    Identifier: imarina:9247344
    Handle: http://hdl.handle.net/20.500.11797/imarina9247344
  • Authors:

    Acevedo-León D
    Gómez-Abril SÁ
    Monzó-Beltrán L
    Estañ-Capell N
    Arroyo-Montañés R
    Bañuls C
    Salas-Salvadó J
    Sáez G
  • Others:

    Author, as appears in the article.: Acevedo-León D; Gómez-Abril SÁ; Monzó-Beltrán L; Estañ-Capell N; Arroyo-Montañés R; Bañuls C; Salas-Salvadó J; Sáez G
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Salas Salvadó, Jorge
    Keywords: Virgin olive oil Oxidative stress Mediterranean diet Colorectal cancer Antioxidants 8-oxodg risk red processed meat prevention oxidative stress men mediterranean diet intervention improves cardiovascular-disease antioxidants 8-oxodg
    Abstract: Oxidative stress (OS) and inflammation have been related to colorectal cancer (CRC), but the influence of the Mediterranean diet (MD) on these parameters is unknown. Therefore, the aim of this study was to determine the association between adherence to the MD and markers of OS and DNA damage in CRC patients and to study the influence of adherence to the MD on metabolic and tumor-related factors. This prospective observational study included a total of 80 patients diagnosed with CRC. Adherence to the MD was estimated by the 14-item Mediterranean Diet Adherence Screener (MEDAS) questionnaire. The levels of OS markers (catalase, glutathione peroxidase, and glutathione system in serum; 8-oxo-7′ 8-dihydro-2′-deoxyguanosine and F2-isoprotanes in urine) and tumor and metabolic factors were determined. A total of 51.2% of our CRC patients showed a high adherence to the MD. These patients presented decreased levels of 8-oxodG, increased GPX and HDL–cholesterol levels, and a downward trend in the GSSG/GSH ratio with respect to patients with low adherence to the MD. In addition, a high adherence to the MD was associated with a lower histological grade of the tumor and a lower presence of synchronous adenomas. We conclude that a high adherence to the MD has a protective role against metabolic and oxidative DNA damage and improves antioxidant systems in CRC patients.
    Thematic Areas: Química Physiology Molecular biology Medicina ii Medicina i Interdisciplinar Food science & technology Food science Farmacia Engenharias ii Clinical biochemistry Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Chemistry, medicinal Cell biology Biotecnología Biodiversidade Biochemistry & molecular biology Biochemistry
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: jordi.salas@urv.cat
    Author identifier: 0000-0003-2700-7459
    Record's date: 2023-02-19
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: mdpi.com/2076-3921/11/3/499
    Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Antioxidants. 11 (3):
    APA: Acevedo-León D; Gómez-Abril SÁ; Monzó-Beltrán L; Estañ-Capell N; Arroyo-Montañés R; Bañuls C; Salas-Salvadó J; Sáez G (2022). Adherence to the Mediterranean Diet Has a Protective Role against Metabolic and DNA Damage Markers in Colorectal Cancer Patients. Antioxidants, 11(3), -. DOI: 10.3390/antiox11030499
    Article's DOI: 10.3390/antiox11030499
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2022
    Publication Type: Journal Publications
  • Keywords:

    Biochemistry,Biochemistry & Molecular Biology,Cell Biology,Chemistry, Medicinal,Clinical Biochemistry,Food Science & Technology,Molecular Biology,Physiology
    Virgin olive oil
    Oxidative stress
    Mediterranean diet
    Colorectal cancer
    Antioxidants
    8-oxodg
    risk
    red
    processed meat
    prevention
    oxidative stress
    men
    mediterranean diet
    intervention
    improves
    cardiovascular-disease
    antioxidants
    8-oxodg
    Química
    Physiology
    Molecular biology
    Medicina ii
    Medicina i
    Interdisciplinar
    Food science & technology
    Food science
    Farmacia
    Engenharias ii
    Clinical biochemistry
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Chemistry, medicinal
    Cell biology
    Biotecnología
    Biodiversidade
    Biochemistry & molecular biology
    Biochemistry
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