Author, as appears in the article.: Rodriguez-Tomas, Elisabet; Acosta, Johana C.; Torres-Royo, Laura; De Febrer, Gabriel; Baiges-Gaya, Gerard; Castane, Helena; Jimenez, Andrea; Vasco, Carlos; Araguas, Pablo; Gomez, Junior; Malave, Barbara; Arquez, Miguel; Calderon, David; Pique, Berta; Algara, Manel; Montero, Angel; Simo, Josep M.; Gabaldo-Barrios, Xavier; Sabater, Sebastia; Camps, Jordi; Joven, Jorge; Arenas, Meritxell;

Department: Ciències Mèdiques Bàsiques Medicina i Cirurgia

URV's Author/s: Arenas Prat, Meritxell / Baiges Gaya, Gerard / Camps Andreu, Jorge / Joven Maried, Jorge / Piqué Smith, Berta / Rodriguez Tomas, Elisabet

Keywords: Radiation Paraoxonases-1 Paraoxonase-1 Mouse Low-dose radiation therapy Immunohistochemical analysis Expression Covid-19 pneumonia Chemokines

Abstract: The aim of our study was to investigate the changes produced by low-dose radiotherapy (LDRT) in the circulating levels of the antioxidant enzyme paraoxonase-1 (PON1) and inflammatory markers in patients with COVID-19 pneumonia treated with LDRT and their interactions with clinical and radiological changes. Data were collected from the IPACOVID prospective clinical trial (NCT04380818). The study included 30 patients treated with a whole-lung dose of 0.5 Gy. Clinical follow-up, as well as PON1-related variables, cytokines, and radiological parameters were analyzed before LDRT, at 24 h, and 1 week after treatment. Twenty-five patients (83.3%) survived 1 week after LDRT. Respiratory function and radiological images improved in survivors. Twenty-four hours after LDRT, PON1 concentration significantly decreased, while transforming growth factor beta 1 (TGF-beta 1) increased with respect to baseline. One week after LDRT, patients had increased PON1 activities and lower PON1 and TGF-beta 1 concentrations compared with 24 h after LDRT, PON1 specific activity increased, lactate dehydrogenase (LDH), and C-reactive protein (CRP) decreased, and CD4+ and CD8+ cells increased after one week. Our results highlight the benefit of LDRT in patients with COVID-19 pneumonia and it might be mediated, at least in part, by an increase in serum PON1 activity at one week and an increase in TGF-beta 1 concentrations at 24 h.

Thematic Areas: Química Physiology Molecular biology Medicina ii Medicina i Interdisciplinar Food science & technology Food science Farmacia Engenharias ii Clinical biochemistry Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Chemistry, medicinal Cell biology Biotecnología Biodiversidade Biochemistry & molecular biology Biochemistry

licence for use: https://creativecommons.org/licenses/by/3.0/es/

Author's mail: jorge.camps@urv.cat jorge.joven@urv.cat meritxell.arenas@urv.cat elisabet.rodriguez@urv.cat gerard.baiges@estudiants.urv.cat berta.pique@estudiants.urv.cat

Author identifier: 0000-0002-3165-3640 0000-0003-2749-4541 0000-0003-0815-2570

Record's date: 2023-02-19

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.mdpi.com/2076-3921/11/6/1184

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Antioxidants. 11 (6):

APA: Rodriguez-Tomas, Elisabet; Acosta, Johana C.; Torres-Royo, Laura; De Febrer, Gabriel; Baiges-Gaya, Gerard; Castane, Helena; Jimenez, Andrea; Vasco, Ca (2022). Effect of Low-Dose Radiotherapy on the Circulating Levels of Paraoxonase-1-Related Variables and Markers of Inflammation in Patients with COVID-19 Pneumonia. Antioxidants, 11(6), -. DOI: 10.3390/antiox11061184

Article's DOI: 10.3390/antiox11061184

Entity: Universitat Rovira i Virgili

Journal publication year: 2022

Publication Type: Journal Publications