Author, as appears in the article.: Rodriguez-Tomas, Elisabet; Acosta, Johana C; Torres-Royo, Laura; De Febrer, Gabriel; Baiges-Gaya, Gerard; Castane, Helena; Jimenez, Andrea; Vasco, Carlos; Araguas, Pablo; Gomez, Junior; Malave, Barbara; Arquez, Miguel; Calderon, David; Pique, Berta; Algara, Manel; Montero, Angel; Simo, Josep M; Gabaldo-Barrios, Xavier; Sabater, Sebastia; Camps, Jordi; Joven, Jorge; Arenas, Meritxell
Department: Ciències Mèdiques Bàsiques; Medicina i Cirurgia
URV's Author/s: Arenas Prat, Meritxell / Arquez Pianetta, Miguel / Baiges Gaya, Gerard / Calderon Garrido, Diego Mariano / Camps Andreu, Jorge / Castañé Vilafranca, Helena / Gómez Alvarez, Josep / JIMÉNEZ ARANDA, ANGEL / Joven Maried, Jorge / Piqué Smith, Berta / Rodriguez Tomas, Elisabet
Keywords: Radiation; Paraoxonases-1; Paraoxonase-1; Mouse; Low-dose radiation therapy; Immunohistochemical analysis; Expression; Covid-19 pneumonia; Chemokines
Abstract: The aim of our study was to investigate the changes produced by low-dose radiotherapy (LDRT) in the circulating levels of the antioxidant enzyme paraoxonase-1 (PON1) and inflammatory markers in patients with COVID-19 pneumonia treated with LDRT and their interactions with clinical and radiological changes. Data were collected from the IPACOVID prospective clinical trial (NCT04380818). The study included 30 patients treated with a whole-lung dose of 0.5 Gy. Clinical follow-up, as well as PON1-related variables, cytokines, and radiological parameters were analyzed before LDRT, at 24 h, and 1 week after treatment. Twenty-five patients (83.3%) survived 1 week after LDRT. Respiratory function and radiological images improved in survivors. Twenty-four hours after LDRT, PON1 concentration significantly decreased, while transforming growth factor beta 1 (TGF-beta 1) increased with respect to baseline. One week after LDRT, patients had increased PON1 activities and lower PON1 and TGF-beta 1 concentrations compared with 24 h after LDRT, PON1 specific activity increased, lactate dehydrogenase (LDH), and C-reactive protein (CRP) decreased, and CD4+ and CD8+ cells increased after one week. Our results highlight the benefit of LDRT in patients with COVID-19 pneumonia and it might be mediated, at least in part, by an increase in serum PON1 activity at one week and an increase in TGF-beta 1 concentrations at 24 h.
Thematic Areas: Química; Physiology; Molecular biology; Medicina ii; Medicina i; Interdisciplinar; Food science & technology; Food science; Farmacia; Engenharias ii; Clinical biochemistry; Ciências biológicas ii; Ciências biológicas i; Ciências ambientais; Ciências agrárias i; Ciência de alimentos; Chemistry, medicinal; Cell biology; Biotecnología; Biodiversidade; Biochemistry & molecular biology; Biochemistry
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: miguel.arquez@urv.cat; josep.gomez@urv.cat; diego.calderon@urv.cat; jorge.camps@urv.cat; berta.pique@estudiants.urv.cat; miguel.arquez@urv.cat; helena.castane@estudiants.urv.cat; gerard.baiges@estudiants.urv.cat; elisabet.rodriguezt@estudiants.urv.cat; elisabet.rodriguezt@estudiants.urv.cat; meritxell.arenas@urv.cat; jorge.joven@urv.cat
Record's date: 2025-03-15
Paper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.mdpi.com/2076-3921/11/6/1184
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Paper original source: Antioxidants. 11 (6): 1184-
APA: Rodriguez-Tomas, Elisabet; Acosta, Johana C; Torres-Royo, Laura; De Febrer, Gabriel; Baiges-Gaya, Gerard; Castane, Helena; Jimenez, Andrea; Vasco, Car (2022). Effect of Low-Dose Radiotherapy on the Circulating Levels of Paraoxonase-1-Related Variables and Markers of Inflammation in Patients with COVID-19 Pneumonia. Antioxidants, 11(6), 1184-. DOI: 10.3390/antiox11061184
Article's DOI: 10.3390/antiox11061184
Entity: Universitat Rovira i Virgili
Journal publication year: 2022
Publication Type: Journal Publications
Repositori URV