Autor según el artículo: Rodriguez-Tomas, Elisabet; Acosta, Johana C.; Torres-Royo, Laura; De Febrer, Gabriel; Baiges-Gaya, Gerard; Castane, Helena; Jimenez, Andrea; Vasco, Carlos; Araguas, Pablo; Gomez, Junior; Malave, Barbara; Arquez, Miguel; Calderon, David; Pique, Berta; Algara, Manel; Montero, Angel; Simo, Josep M.; Gabaldo-Barrios, Xavier; Sabater, Sebastia; Camps, Jordi; Joven, Jorge; Arenas, Meritxell;
Departamento: Ciències Mèdiques Bàsiques Medicina i Cirurgia
Autor/es de la URV: Arenas Prat, Meritxell / Arquez Pianetta, Miguel / Baiges Gaya, Gerard / Calderon Garrido, Diego Mariano / Camps Andreu, Jorge / Castañé Vilafranca, Helena / Gómez Alvarez, Josep / JIMÉNEZ ARANDA, ANGEL / Joven Maried, Jorge / Piqué Smith, Berta / Rodriguez Tomas, Elisabet
Palabras clave: Radiation Paraoxonases-1 Paraoxonase-1 Mouse Low-dose radiation therapy Immunohistochemical analysis Expression Covid-19 pneumonia Chemokines
Resumen: The aim of our study was to investigate the changes produced by low-dose radiotherapy (LDRT) in the circulating levels of the antioxidant enzyme paraoxonase-1 (PON1) and inflammatory markers in patients with COVID-19 pneumonia treated with LDRT and their interactions with clinical and radiological changes. Data were collected from the IPACOVID prospective clinical trial (NCT04380818). The study included 30 patients treated with a whole-lung dose of 0.5 Gy. Clinical follow-up, as well as PON1-related variables, cytokines, and radiological parameters were analyzed before LDRT, at 24 h, and 1 week after treatment. Twenty-five patients (83.3%) survived 1 week after LDRT. Respiratory function and radiological images improved in survivors. Twenty-four hours after LDRT, PON1 concentration significantly decreased, while transforming growth factor beta 1 (TGF-beta 1) increased with respect to baseline. One week after LDRT, patients had increased PON1 activities and lower PON1 and TGF-beta 1 concentrations compared with 24 h after LDRT, PON1 specific activity increased, lactate dehydrogenase (LDH), and C-reactive protein (CRP) decreased, and CD4+ and CD8+ cells increased after one week. Our results highlight the benefit of LDRT in patients with COVID-19 pneumonia and it might be mediated, at least in part, by an increase in serum PON1 activity at one week and an increase in TGF-beta 1 concentrations at 24 h.
Áreas temáticas: Química Physiology Molecular biology Medicina ii Medicina i Interdisciplinar Food science & technology Food science Farmacia Engenharias ii Clinical biochemistry Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Chemistry, medicinal Cell biology Biotecnología Biodiversidade Biochemistry & molecular biology Biochemistry
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: miguel.arquez@urv.cat josep.gomez@urv.cat diego.calderon@urv.cat jorge.camps@urv.cat berta.pique@estudiants.urv.cat miguel.arquez@urv.cat helena.castane@estudiants.urv.cat gerard.baiges@estudiants.urv.cat elisabet.rodriguezt@estudiants.urv.cat elisabet.rodriguezt@estudiants.urv.cat meritxell.arenas@urv.cat jorge.joven@urv.cat
Identificador del autor: 0000-0002-0573-7621 0000-0002-3165-3640 0000-0003-0815-2570 0000-0003-2749-4541
Fecha de alta del registro: 2024-09-07
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.mdpi.com/2076-3921/11/6/1184
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Antioxidants. 11 (6):
Referencia de l'ítem segons les normes APA: Rodriguez-Tomas, Elisabet; Acosta, Johana C.; Torres-Royo, Laura; De Febrer, Gabriel; Baiges-Gaya, Gerard; Castane, Helena; Jimenez, Andrea; Vasco, Ca (2022). Effect of Low-Dose Radiotherapy on the Circulating Levels of Paraoxonase-1-Related Variables and Markers of Inflammation in Patients with COVID-19 Pneumonia. Antioxidants, 11(6), -. DOI: 10.3390/antiox11061184
DOI del artículo: 10.3390/antiox11061184
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2022
Tipo de publicación: Journal Publications