Author, as appears in the article.: Sanchez-Gimenez, Raul; Ahmed-Khodja, Wahiba; Molina, Yesica; Peiro, Oscar M; Bonet, Gil; Carrasquer, Anna; Fragkiadakis, George A; Bullo, Monica; Bardaji, Alfredo; Papandreou, Christopher
Department: Medicina i Cirurgia Bioquímica i Biotecnologia
URV's Author/s: Ahmed-Khodja, Wahiba / Bardají Ruiz, Alfredo / Bonet Pineda, Gil / Bulló Bonet, Mònica / Carrasquer Cucarella, Ana Maria / Molina Castro, Yésica / Peiró Ibáñez, Óscar Manuel / Sánchez Giménez, Raúl
Keywords: Tryptophan Trimethylamine-n-oxide Serum Prospective studies Profiles Mortality Methylamines Metabolites Men Indoles Humans Health Gut microbiota Gastrointestinal microbiome Coronary Cardiovascular diseases Cardiovascular disease Bile acids and salts Association Amino acids, branched-chain All-cause mortality Acids
Abstract: Gut microbiota-derived metabolites have recently attracted considerable attention due to their role in host-microbial crosstalk and their link with cardiovascular health. The MEDLINE-PubMed and Elsevier's Scopus databases were searched up to June 2022 for studies evaluating the association of baseline circulating levels of trimethylamine N-oxide (TMAO), secondary bile acids, short-chain fatty acids (SCFAs), branched-chain amino acids (BCAAs), tryptophan and indole derivatives, with risk of cardiovascular disease (CVD). A total of twenty-one studies were included in the systematic review after evaluating 1210 non-duplicate records. There were nineteen of the twenty-one studies that were cohort studies and two studies had a nested case-control design. All of the included studies were of high quality according to the "Newcastle-Ottawa Scale". TMAO was positively associated with adverse cardiovascular events and CVD/all-cause mortality in some, but not all of the included studies. Bile acids were associated with atrial fibrillation and CVD/all-cause mortality, but not with CVD. Positive associations were found between BCAAs and CVD, and between indole derivatives and major adverse cardiovascular events, while a negative association was reported between tryptophan and all-cause mortality. No studies examining the relationship between SCFAs and CVD risk were identified. Evidence from prospective studies included in the systematic review supports a role of microbial metabolites in CVD.
Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: gil.bonet@urv.cat oscarmanuel.peiro@urv.cat anamaria.carrasquer@urv.cat wahiba.ahmed-khodja@urv.cat raul.sanchez@estudiants.urv.cat yesica.molina@estudiants.urv.cat oscarmanuel.peiro@urv.cat anamaria.carrasquer@urv.cat monica.bullo@urv.cat alfredo.bardaji@urv.cat
Author identifier: 0000-0002-0218-7046 0000-0003-1900-6974
Record's date: 2024-10-12
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.mdpi.com/2072-6643/14/13/2654
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Nutrients. 14 (13): 2654-
APA: Sanchez-Gimenez, Raul; Ahmed-Khodja, Wahiba; Molina, Yesica; Peiro, Oscar M; Bonet, Gil; Carrasquer, Anna; Fragkiadakis, George A; Bullo, Monica; Bard (2022). Gut Microbiota-Derived Metabolites and Cardiovascular Disease Risk: A Systematic Review of Prospective Cohort Studies. Nutrients, 14(13), 2654-. DOI: 10.3390/nu14132654
Article's DOI: 10.3390/nu14132654
Entity: Universitat Rovira i Virgili
Journal publication year: 2022
Publication Type: Journal Publications