Articles producció científica> Medicina i Cirurgia

Gut Microbiota-Derived Metabolites and Cardiovascular Disease Risk: A Systematic Review of Prospective Cohort Studies

  • Identification data

    Identifier: imarina:9272134
    Handle: http://hdl.handle.net/20.500.11797/imarina9272134
  • Authors:

    Sanchez-Gimenez, Raul
    Ahmed-Khodja, Wahiba
    Molina, Yesica
    Peiro, Oscar M.
    Bonet, Gil
    Carrasquer, Anna
    Fragkiadakis, George A.
    Bullo, Monica
    Bardaji, Alfredo
    Papandreou, Christopher
  • Others:

    Author, as appears in the article.: Sanchez-Gimenez, Raul; Ahmed-Khodja, Wahiba; Molina, Yesica; Peiro, Oscar M.; Bonet, Gil; Carrasquer, Anna; Fragkiadakis, George A.; Bullo, Monica; Bardaji, Alfredo; Papandreou, Christopher;
    Department: Medicina i Cirurgia Bioquímica i Biotecnologia
    URV's Author/s: Ahmed-Khodja, Wahiba / Bardají Ruiz, Alfredo / Bulló Bonet, Mònica
    Keywords: Trimethylamine-n-oxide Serum Profiles Mortality Metabolites Men Health Gut microbiota Coronary Cardiovascular disease Association All-cause mortality Acids
    Abstract: Gut microbiota-derived metabolites have recently attracted considerable attention due to their role in host-microbial crosstalk and their link with cardiovascular health. The MEDLINE-PubMed and Elsevier's Scopus databases were searched up to June 2022 for studies evaluating the association of baseline circulating levels of trimethylamine N-oxide (TMAO), secondary bile acids, short-chain fatty acids (SCFAs), branched-chain amino acids (BCAAs), tryptophan and indole derivatives, with risk of cardiovascular disease (CVD). A total of twenty-one studies were included in the systematic review after evaluating 1210 non-duplicate records. There were nineteen of the twenty-one studies that were cohort studies and two studies had a nested case-control design. All of the included studies were of high quality according to the "Newcastle-Ottawa Scale". TMAO was positively associated with adverse cardiovascular events and CVD/all-cause mortality in some, but not all of the included studies. Bile acids were associated with atrial fibrillation and CVD/all-cause mortality, but not with CVD. Positive associations were found between BCAAs and CVD, and between indole derivatives and major adverse cardiovascular events, while a negative association was reported between tryptophan and all-cause mortality. No studies examining the relationship between SCFAs and CVD risk were identified. Evidence from prospective studies included in the systematic review supports a role of microbial metabolites in CVD.
    Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: alfredo.bardaji@urv.cat monica.bullo@urv.cat wahiba.ahmed-khodja@urv.cat
    Author identifier: 0000-0003-1900-6974 0000-0002-0218-7046
    Record's date: 2023-02-23
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.mdpi.com/2072-6643/14/13/2654
    Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Nutrients. 14 (13):
    APA: Sanchez-Gimenez, Raul; Ahmed-Khodja, Wahiba; Molina, Yesica; Peiro, Oscar M.; Bonet, Gil; Carrasquer, Anna; Fragkiadakis, George A.; Bullo, Monica; Ba (2022). Gut Microbiota-Derived Metabolites and Cardiovascular Disease Risk: A Systematic Review of Prospective Cohort Studies. Nutrients, 14(13), -. DOI: 10.3390/nu14132654
    Article's DOI: 10.3390/nu14132654
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2022
    Publication Type: Journal Publications
  • Keywords:

    Food Science,Nutrition & Dietetics,Nutrition and Dietetics
    Trimethylamine-n-oxide
    Serum
    Profiles
    Mortality
    Metabolites
    Men
    Health
    Gut microbiota
    Coronary
    Cardiovascular disease
    Association
    All-cause mortality
    Acids
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Psicología
    Planejamento urbano e regional / demografia
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Food science
    Farmacia
    Engenharias iv
    Engenharias ii
    Enfermagem
    Educação física
    Economia
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
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