Articles producció científica> Medicina i Cirurgia

DNA Methylation in Gestational Diabetes and its Predictive Value for Postpartum Glucose Disturbances

  • Identification data

    Identifier: imarina:9280699
    Authors:
    Ballesteros, MonicaGil-Lluis, PilarEjarque, MiriamDiaz-Perdigones, CristinaMartinez-Guasch, LaiaFernandez-Veledo, SoniaVendrell, JoanMegia, Ana
    Abstract:
    Context DNA methylation in the diagnosis of gestational diabetes. Objective To assess the value of DNA methylation in the diagnosis of gestational diabetes (GDM) and in the prediction of maternal postpartum glucose disturbances. Methods Two-stage observational study performed between July 2006 and December 2010, at University Hospital. Forty-eight randomly selected pregnant women formed the discovery cohort (24 with GDM and 24 controls) and 252 pregnant women (94 with GDM and 158 controls) formed the replication cohort. GDM women were re-evaluated 4 years postpartum. The main outcome measures were GDM, type 2 diabetes or prediabetes at 4 years postpartum. Results We identified 3 CpG sites related to LINC00917, TRAPPC9, and LEF1 that were differentially methylated in women with GDM and abnormal glucose tolerance; and sites associated with LINC00917 and TRAPPC9 were independently associated with an abnormal glucose tolerance status 4 years postpartum after controlling for clinical variables. Moreover, the site associated with LINC00917 and the combination of the 3 sites had the highest predictive values. Conclusion Our results suggest that some of these sites may be implicated in the development of GDM and postpartum abnormal glucose tolerance.
  • Others:

    Author, as appears in the article.: Ballesteros, Monica; Gil-Lluis, Pilar; Ejarque, Miriam; Diaz-Perdigones, Cristina; Martinez-Guasch, Laia; Fernandez-Veledo, Sonia; Vendrell, Joan; Megia, Ana;
    Department: Medicina i Cirurgia
    URV's Author/s: Ballesteros Pérez, Monica / Fernandez Veledo, Sonia / Martínez Guasch, Laia / Megía Colet, Ana / Vendrell Ortega, Juan José
    Keywords: Women Pregnancies Postpartum glucose disturbance Pathway Obesity Mellitus Gestational diabetes Epigenetic Dna methylation Disease Cord blood Association Adipogenesis
    Abstract: Context DNA methylation in the diagnosis of gestational diabetes. Objective To assess the value of DNA methylation in the diagnosis of gestational diabetes (GDM) and in the prediction of maternal postpartum glucose disturbances. Methods Two-stage observational study performed between July 2006 and December 2010, at University Hospital. Forty-eight randomly selected pregnant women formed the discovery cohort (24 with GDM and 24 controls) and 252 pregnant women (94 with GDM and 158 controls) formed the replication cohort. GDM women were re-evaluated 4 years postpartum. The main outcome measures were GDM, type 2 diabetes or prediabetes at 4 years postpartum. Results We identified 3 CpG sites related to LINC00917, TRAPPC9, and LEF1 that were differentially methylated in women with GDM and abnormal glucose tolerance; and sites associated with LINC00917 and TRAPPC9 were independently associated with an abnormal glucose tolerance status 4 years postpartum after controlling for clinical variables. Moreover, the site associated with LINC00917 and the combination of the 3 sites had the highest predictive values. Conclusion Our results suggest that some of these sites may be implicated in the development of GDM and postpartum abnormal glucose tolerance.
    Thematic Areas: Sociología Saúde coletiva Odontología Nutrição Medicine (miscellaneous) Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Engenharias ii Enfermagem Endocrinology, diabetes and metabolism Endocrinology & metabolism Endocrinology Educação física Clinical biochemistry Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología Biochemistry (medical) Biochemistry
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: laia.martinez@urv.cat laia.martinez@urv.cat monica.ballesteros@urv.cat sonia.fernandez@urv.cat ana.megia@urv.cat juanjose.vendrell@urv.cat
    Author identifier: 0000-0003-2906-3788 0000-0002-5101-9452 0000-0002-6994-6115
    Record's date: 2024-09-07
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://academic.oup.com/jcem/article/107/10/2748/6653115
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Journal Of Clinical Endocrinology & Metabolism. 107 (10): 2748-2757
    APA: Ballesteros, Monica; Gil-Lluis, Pilar; Ejarque, Miriam; Diaz-Perdigones, Cristina; Martinez-Guasch, Laia; Fernandez-Veledo, Sonia; Vendrell, Joan; Meg (2022). DNA Methylation in Gestational Diabetes and its Predictive Value for Postpartum Glucose Disturbances. Journal Of Clinical Endocrinology & Metabolism, 107(10), 2748-2757. DOI: 10.1210/clinem/dgac462
    Article's DOI: 10.1210/clinem/dgac462
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2022
    Publication Type: Journal Publications
  • Keywords:

    Biochemistry,Biochemistry (Medical),Clinical Biochemistry,Endocrinology,Endocrinology & Metabolism,Endocrinology, Diabetes and Metabolism,Medicine (Miscellaneous)
    Women
    Pregnancies
    Postpartum glucose disturbance
    Pathway
    Obesity
    Mellitus
    Gestational diabetes
    Epigenetic
    Dna methylation
    Disease
    Cord blood
    Association
    Adipogenesis
    Sociología
    Saúde coletiva
    Odontología
    Nutrição
    Medicine (miscellaneous)
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    General medicine
    Farmacia
    Engenharias ii
    Enfermagem
    Endocrinology, diabetes and metabolism
    Endocrinology & metabolism
    Endocrinology
    Educação física
    Clinical biochemistry
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Biotecnología
    Biochemistry (medical)
    Biochemistry
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