Autor según el artículo: Ballesteros, Monica; Gil-Lluis, Pilar; Ejarque, Miriam; Diaz-Perdigones, Cristina; Martinez-Guasch, Laia; Fernandez-Veledo, Sonia; Vendrell, Joan; Megia, Ana;
Departamento: Medicina i Cirurgia
Autor/es de la URV: Ballesteros Pérez, Monica / Fernandez Veledo, Sonia / Martínez Guasch, Laia / Megía Colet, Ana / Vendrell Ortega, Juan José
Palabras clave: Women Pregnancies Postpartum glucose disturbance Pathway Obesity Mellitus Gestational diabetes Epigenetic Dna methylation Disease Cord blood Association Adipogenesis
Resumen: Context DNA methylation in the diagnosis of gestational diabetes. Objective To assess the value of DNA methylation in the diagnosis of gestational diabetes (GDM) and in the prediction of maternal postpartum glucose disturbances. Methods Two-stage observational study performed between July 2006 and December 2010, at University Hospital. Forty-eight randomly selected pregnant women formed the discovery cohort (24 with GDM and 24 controls) and 252 pregnant women (94 with GDM and 158 controls) formed the replication cohort. GDM women were re-evaluated 4 years postpartum. The main outcome measures were GDM, type 2 diabetes or prediabetes at 4 years postpartum. Results We identified 3 CpG sites related to LINC00917, TRAPPC9, and LEF1 that were differentially methylated in women with GDM and abnormal glucose tolerance; and sites associated with LINC00917 and TRAPPC9 were independently associated with an abnormal glucose tolerance status 4 years postpartum after controlling for clinical variables. Moreover, the site associated with LINC00917 and the combination of the 3 sites had the highest predictive values. Conclusion Our results suggest that some of these sites may be implicated in the development of GDM and postpartum abnormal glucose tolerance.
Áreas temáticas: Sociología Saúde coletiva Odontología Nutrição Medicine (miscellaneous) Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Engenharias ii Enfermagem Endocrinology, diabetes and metabolism Endocrinology & metabolism Endocrinology Educação física Clinical biochemistry Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología Biochemistry (medical) Biochemistry
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: laia.martinez@urv.cat monica.ballesteros@urv.cat sonia.fernandez@urv.cat juanjose.vendrell@urv.cat ana.megia@urv.cat laia.martinez@urv.cat
Identificador del autor: 0000-0003-2906-3788 0000-0002-6994-6115 0000-0002-5101-9452
Fecha de alta del registro: 2023-02-19
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://academic.oup.com/jcem/article/107/10/2748/6653115
URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Journal Of Clinical Endocrinology & Metabolism. 107 (10): 2748-2757
Referencia de l'ítem segons les normes APA: Ballesteros, Monica; Gil-Lluis, Pilar; Ejarque, Miriam; Diaz-Perdigones, Cristina; Martinez-Guasch, Laia; Fernandez-Veledo, Sonia; Vendrell, Joan; Meg (2022). DNA Methylation in Gestational Diabetes and its Predictive Value for Postpartum Glucose Disturbances. Journal Of Clinical Endocrinology & Metabolism, 107(10), 2748-2757. DOI: 10.1210/clinem/dgac462
DOI del artículo: 10.1210/clinem/dgac462
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2022
Tipo de publicación: Journal Publications
Repositori URV