Articles producció científica> Enginyeria Química

Formation of biocompatible MgO/cellulose grafted hydrogel for efficient bactericidal and controlled release of doxorubicin

  • Identification data

    Identifier: imarina:9281736
    Authors:
    Shahzadi IIslam MSaeed HHaider AShahzadi AHaider JAhmed NUl-Hamid ANabgan WIkram MRathore HA
    Abstract:
    In this study, MgO-doped CNC-g-PAA hydrogel was synthesized by grafting poly (acrylic acid) (PAA) onto cellulose nanocrystals (CNC) and then doped Magnesium oxide (MgO) using pH 7.0 and 12.0 to obtain an efficient nanocomposite hydrogel for antibacterial and anti-cancer activities. The synthesized nanocomposite hydrogels were evaluated by detailed characterization and confirmed the formation of a well-interconnected porous structure. MgO/CNC-g-PAA (pH = 12.0) exhibited improved bactericidal tendencies towards gram-negative and gram-positive bacteria, which was further investigated by in-silico molecular docking analyses and also examined the reactive oxygen species production by photocatalysis and free radical-scavenging assay. After this, Doxorubicin (DOX), a model anticancer drug, was successfully loaded into nanocomposites (∼79 %) by electrostatic interaction and confirmed pH-triggered based release, which was over 53.7 % in 24 h. Finally, in vitro cytotoxicity-based analysis confirmed the improved antitumor efficacy of nanocomposite hydrogels. These findings revealed that MgO/CNC-g-PAA hydrogels might be prospective carriers for controlled drug delivery.
  • Others:

    Author, as appears in the article.: Shahzadi I; Islam M; Saeed H; Haider A; Shahzadi A; Haider J; Ahmed N; Ul-Hamid A; Nabgan W; Ikram M; Rathore HA
    Department: Enginyeria Química
    URV's Author/s: Nabgan, Walid
    Keywords: Poly (acrylic acid) (paa) Hydrogel Drug-delivery Cellulose nanocrystals (cnc) therapy polymer poly (acrylic acid) (paa) particles mgo nanoparticles hydrogel cellulose nanocrystals antibacterial
    Abstract: In this study, MgO-doped CNC-g-PAA hydrogel was synthesized by grafting poly (acrylic acid) (PAA) onto cellulose nanocrystals (CNC) and then doped Magnesium oxide (MgO) using pH 7.0 and 12.0 to obtain an efficient nanocomposite hydrogel for antibacterial and anti-cancer activities. The synthesized nanocomposite hydrogels were evaluated by detailed characterization and confirmed the formation of a well-interconnected porous structure. MgO/CNC-g-PAA (pH = 12.0) exhibited improved bactericidal tendencies towards gram-negative and gram-positive bacteria, which was further investigated by in-silico molecular docking analyses and also examined the reactive oxygen species production by photocatalysis and free radical-scavenging assay. After this, Doxorubicin (DOX), a model anticancer drug, was successfully loaded into nanocomposites (∼79 %) by electrostatic interaction and confirmed pH-triggered based release, which was over 53.7 % in 24 h. Finally, in vitro cytotoxicity-based analysis confirmed the improved antitumor efficacy of nanocomposite hydrogels. These findings revealed that MgO/CNC-g-PAA hydrogels might be prospective carriers for controlled drug delivery.
    Thematic Areas: Zootecnia / recursos pesqueiros Structural biology Química Polymer science Planejamento urbano e regional / demografia Odontología Nutrição Molecular biology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Geociências General energy Food science Farmacia Ensino Engenharias iv Engenharias iii Engenharias ii Engenharias i Energy (miscellaneous) Economics and econometrics Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Chemistry, applied Biotecnología Biomaterials Biodiversidade Biochemistry & molecular biology Biochemistry Astronomia / física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: walid.nabgan@urv.cat
    Author identifier: 0000-0001-9901-862X
    Record's date: 2024-09-07
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.sciencedirect.com/science/article/abs/pii/S0141813022018451?via%3Dihub
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: International Journal Of Biological Macromolecules. 220 1277-1286
    APA: Shahzadi I; Islam M; Saeed H; Haider A; Shahzadi A; Haider J; Ahmed N; Ul-Hamid A; Nabgan W; Ikram M; Rathore HA (2022). Formation of biocompatible MgO/cellulose grafted hydrogel for efficient bactericidal and controlled release of doxorubicin. International Journal Of Biological Macromolecules, 220(), 1277-1286. DOI: 10.1016/j.ijbiomac.2022.08.142
    Article's DOI: 10.1016/j.ijbiomac.2022.08.142
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2022
    Publication Type: Journal Publications
  • Keywords:

    Biochemistry,Biochemistry & Molecular Biology,Chemistry, Applied,Economics and Econometrics,Energy (Miscellaneous),Medicine (Miscellaneous),Molecular Biology,Polymer Science,Structural Biology
    Poly (acrylic acid) (paa)
    Hydrogel
    Drug-delivery
    Cellulose nanocrystals (cnc)
    therapy
    polymer
    poly (acrylic acid) (paa)
    particles
    mgo nanoparticles
    hydrogel
    cellulose nanocrystals
    antibacterial
    Zootecnia / recursos pesqueiros
    Structural biology
    Química
    Polymer science
    Planejamento urbano e regional / demografia
    Odontología
    Nutrição
    Molecular biology
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    Geociências
    General energy
    Food science
    Farmacia
    Ensino
    Engenharias iv
    Engenharias iii
    Engenharias ii
    Engenharias i
    Energy (miscellaneous)
    Economics and econometrics
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Chemistry, applied
    Biotecnología
    Biomaterials
    Biodiversidade
    Biochemistry & molecular biology
    Biochemistry
    Astronomia / física
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