Autor según el artículo: Shahzadi I; Islam M; Saeed H; Haider A; Shahzadi A; Haider J; Ahmed N; Ul-Hamid A; Nabgan W; Ikram M; Rathore HA
Departamento: Enginyeria Química
Autor/es de la URV: Nabgan, Walid
Palabras clave: antibacterial cellulose nanocrystals hydrogel mgo nanoparticles particles poly (acrylic acid) (paa) polymer therapy Cellulose nanocrystals (cnc) Drug-delivery Hydrogel Poly (acrylic acid) (paa)
Resumen: In this study, MgO-doped CNC-g-PAA hydrogel was synthesized by grafting poly (acrylic acid) (PAA) onto cellulose nanocrystals (CNC) and then doped Magnesium oxide (MgO) using pH 7.0 and 12.0 to obtain an efficient nanocomposite hydrogel for antibacterial and anti-cancer activities. The synthesized nanocomposite hydrogels were evaluated by detailed characterization and confirmed the formation of a well-interconnected porous structure. MgO/CNC-g-PAA (pH = 12.0) exhibited improved bactericidal tendencies towards gram-negative and gram-positive bacteria, which was further investigated by in-silico molecular docking analyses and also examined the reactive oxygen species production by photocatalysis and free radical-scavenging assay. After this, Doxorubicin (DOX), a model anticancer drug, was successfully loaded into nanocomposites (∼79 %) by electrostatic interaction and confirmed pH-triggered based release, which was over 53.7 % in 24 h. Finally, in vitro cytotoxicity-based analysis confirmed the improved antitumor efficacy of nanocomposite hydrogels. These findings revealed that MgO/CNC-g-PAA hydrogels might be prospective carriers for controlled drug delivery.
Áreas temáticas: Astronomia / física Biochemistry Biochemistry & molecular biology Biodiversidade Biotecnología Chemistry, applied Ciência de alimentos Ciências agrárias i Ciências ambientais Ciências biológicas i Ciências biológicas ii Ciências biológicas iii Economics and econometrics Energy (miscellaneous) Engenharias i Engenharias ii Engenharias iii Engenharias iv Ensino Farmacia General energy Geociências Interdisciplinar Materiais Medicina i Medicina ii Medicina iii Medicina veterinaria Medicine (miscellaneous) Molecular biology Nutrição Odontología Planejamento urbano e regional / demografia Polymer science Química Structural biology Zootecnia / recursos pesqueiros
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: walid.nabgan@urv.cat
Identificador del autor: 0000-0001-9901-862X
Fecha de alta del registro: 2022-11-12
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.sciencedirect.com/science/article/abs/pii/S0141813022018451?via%3Dihub
Referencia al articulo segun fuente origial: International Journal Of Biological Macromolecules. 220 1277-1286
Referencia de l'ítem segons les normes APA: Shahzadi I; Islam M; Saeed H; Haider A; Shahzadi A; Haider J; Ahmed N; Ul-Hamid A; Nabgan W; Ikram M; Rathore HA (2022). Formation of biocompatible MgO/cellulose grafted hydrogel for efficient bactericidal and controlled release of doxorubicin. International Journal Of Biological Macromolecules, 220(), 1277-1286. DOI: 10.1016/j.ijbiomac.2022.08.142
URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/
DOI del artículo: 10.1016/j.ijbiomac.2022.08.142
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2022
Tipo de publicación: Journal Publications
Repositori URV