Author, as appears in the article.: Martin-Grau, Carla; Diaz-Lopez, Andres; Aparicio, Estefania; Arija, Victoria
Department: Ciències Mèdiques Bàsiques
URV's Author/s: Aparicio Llopis, Estefania / Arija Val, Maria Victoria / Díaz López, Andres / Martín Grau, Carla
Keywords: Tandem mass spectrometry Spain Short chain fatty acid Reference values Reference ranges Pregnant women Pregnant people Pregnancy Parity Mothers Isobutyrates Humans Gut microbiome Follow-up studies Female Eclipses Chromatography, liquid Adult
Abstract: Maternal short-chain fatty acids (SCFAs) play a critical role in fetal development and metabolic programming. However, an important gap in the analysis of such relationships is the lack of reference values in pregnant women. Therefore, we establish serum SCFA percentile reference ranges both early and later in pregnancy in a population from a Mediterranean region of Northern Spain. A population-based follow-up study involving 455 healthy pregnant women (mean age 30.6 +/- 5.0 years) from the ECLIPSES study is conducted. Sociodemographic, obstetric, anthropometric, lifestyle, dietary variables and blood samples were collected in the first and third trimesters. Serum SCFA concentrations were measured by LC-MS/MS. The 2.5/97.5 percentiles of the reference interval for serum acetic, propionic, isobutyric, and butyric acids were 16.4/103.8 mu mol/L, 2.1/5.8 mu mol/L, 0.16/1.01 mu mol/L and 0.32/1.67 mu mol/L in the first trimester of pregnancy, respectively. In the third trimester, butyrate levels increased with most of the maternal factors and categories studied, while acetic acid and isobutyric acid decreased only in some maternal categories. Propionic acid was not affected by maternal factors. Reference ranges did not vary with maternal age, body weight, social class or diet, but decreased with smoking, high physical activity, low BMI and primiparity. This study establishes for the first-time SCFAs reference ranges in serum for women in our region in both early and late pregnancy. This information can be useful to monitor pregnancy follow-up and detect risk values.
Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: andres.diaz@urv.cat carla.martin@estudiants.urv.cat estefania.aparicio@urv.cat victoria.arija@urv.cat
Author identifier: 0000-0002-7500-5629 0000-0003-0542-0015 0000-0002-1758-0975
Record's date: 2025-02-19
Paper version: info:eu-repo/semantics/publishedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Paper original source: Nutrients. 14 (18): 3798-
APA: Martin-Grau, Carla; Diaz-Lopez, Andres; Aparicio, Estefania; Arija, Victoria (2022). Short-Chain Fatty Acid Reference Ranges in Pregnant Women from a Mediterranean Region of Northern Spain: ECLIPSES Study. Nutrients, 14(18), 3798-. DOI: 10.3390/nu14183798
Entity: Universitat Rovira i Virgili
Journal publication year: 2022
Publication Type: Journal Publications