Author, as appears in the article.: Fernandez-Millan, Elisa; Ramos, Sonia; Alvarez-Cilleros, David; Samino, Sara; Amigo, Nuria; Correig, Xavier; Chagoyen, Monica; Alvarez, Carmen; Angeles Martin, Maria;
Department: Enginyeria Electrònica, Elèctrica i Automàtica
URV's Author/s: Correig Blanchar, Francesc Xavier / SAMINO GENÉ, SARA
Keywords: Urine metabolites Untargeted metabolomics Type 2 diabetes Polyphenols Oxidative stress Metabolites Flavonoids Excretion Branched-chain aminoacids Biomarkers Acid
Abstract: Cocoa constitutes one of the richest sources of dietary flavonoids with demonstrated anti-diabetic potential. However, the metabolic impact of cocoa intake in a diabetic context remains unexplored. In this study, metabolomics tools have been used to investigate the potential metabolic changes induced by cocoa in type 2 diabetes (T2D). To this end, male Zucker diabetic fatty rats were fed on standard (ZDF) or 10% cocoa-rich diet (ZDF-C) from week 10 to 20 of life. Cocoa supplementation clearly decreased serum glucose levels, improved glucose metabolism and produced significant changes in the urine metabolome of ZDF animals. Fourteen differential urinary metabolites were identified, with eight of them significantly modified by cocoa. An analysis of pathways revealed that butanoate metabolism and the synthesis and degradation of branched-chain amino acids and ketone bodies are involved in the beneficial impact of cocoa on diabetes. Moreover, correlation analysis indicated major associations between some of these urine metabolites (mainly valine, leucine, and isoleucine) and body weight, glycemia, insulin sensitivity, and glycated hemoglobin levels. Overall, this untargeted metabolomics approach provides a clear metabolic fingerprint associated to chronic cocoa intake that can be used as a marker for the improvement of glucose homeostasis in a diabetic context.
Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: xavier.correig@urv.cat
Author identifier: 0000-0002-6902-3054
Record's date: 2024-09-07
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.mdpi.com/2072-6643/14/19/4127
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Nutrients. 14 (19):
APA: Fernandez-Millan, Elisa; Ramos, Sonia; Alvarez-Cilleros, David; Samino, Sara; Amigo, Nuria; Correig, Xavier; Chagoyen, Monica; Alvarez, Carmen; Angele (2022). Urinary Metabolomics Study on the Protective Role of Cocoa in Zucker Diabetic Rats via H-1-NMR-Based Approach. Nutrients, 14(19), -. DOI: 10.3390/nu14194127
Article's DOI: 10.3390/nu14194127
Entity: Universitat Rovira i Virgili
Journal publication year: 2022
Publication Type: Journal Publications
Repositori URV