Autor según el artículo: Fernandez-Millan, Elisa; Ramos, Sonia; Alvarez-Cilleros, David; Samino, Sara; Amigo, Nuria; Correig, Xavier; Chagoyen, Monica; Alvarez, Carmen; Angeles Martin, Maria;
Departamento: Enginyeria Electrònica, Elèctrica i Automàtica
Autor/es de la URV: Correig Blanchar, Francesc Xavier / SAMINO GENÉ, SARA
Palabras clave: Urine metabolites Untargeted metabolomics Type 2 diabetes Polyphenols Oxidative stress Metabolites Flavonoids Excretion Branched-chain aminoacids Biomarkers Acid
Resumen: Cocoa constitutes one of the richest sources of dietary flavonoids with demonstrated anti-diabetic potential. However, the metabolic impact of cocoa intake in a diabetic context remains unexplored. In this study, metabolomics tools have been used to investigate the potential metabolic changes induced by cocoa in type 2 diabetes (T2D). To this end, male Zucker diabetic fatty rats were fed on standard (ZDF) or 10% cocoa-rich diet (ZDF-C) from week 10 to 20 of life. Cocoa supplementation clearly decreased serum glucose levels, improved glucose metabolism and produced significant changes in the urine metabolome of ZDF animals. Fourteen differential urinary metabolites were identified, with eight of them significantly modified by cocoa. An analysis of pathways revealed that butanoate metabolism and the synthesis and degradation of branched-chain amino acids and ketone bodies are involved in the beneficial impact of cocoa on diabetes. Moreover, correlation analysis indicated major associations between some of these urine metabolites (mainly valine, leucine, and isoleucine) and body weight, glycemia, insulin sensitivity, and glycated hemoglobin levels. Overall, this untargeted metabolomics approach provides a clear metabolic fingerprint associated to chronic cocoa intake that can be used as a marker for the improvement of glucose homeostasis in a diabetic context.
Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: xavier.correig@urv.cat
Identificador del autor: 0000-0002-6902-3054
Fecha de alta del registro: 2024-09-07
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.mdpi.com/2072-6643/14/19/4127
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Nutrients. 14 (19):
Referencia de l'ítem segons les normes APA: Fernandez-Millan, Elisa; Ramos, Sonia; Alvarez-Cilleros, David; Samino, Sara; Amigo, Nuria; Correig, Xavier; Chagoyen, Monica; Alvarez, Carmen; Angele (2022). Urinary Metabolomics Study on the Protective Role of Cocoa in Zucker Diabetic Rats via H-1-NMR-Based Approach. Nutrients, 14(19), -. DOI: 10.3390/nu14194127
DOI del artículo: 10.3390/nu14194127
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2022
Tipo de publicación: Journal Publications