Articles producció científica> Medicina i Cirurgia

Impact of Phenol-Enriched Olive Oils on Serum Metabonome and Its Relationship with Cardiometabolic Parameters: A Randomized, Double-Blind, Cross-Over, Controlled Trial

  • Identification data

    Identifier: imarina:9285876
  • Authors:

    Farras, Marta
    Swann, Jonathan Richard
    Rowland, Ian
    Rubio, Laura
    Subirana, Isaac
    Catalan, Ursula
    Jose Motilva, Maria
    Sola, Rosa
    Covas, Maria Isabel
    Blanco-Vaca, Francisco
    Fito, Montserrat
    Mayneris-Perxachs, Jordi
  • Others:

    Author, as appears in the article.: Farras, Marta; Swann, Jonathan Richard; Rowland, Ian; Rubio, Laura; Subirana, Isaac; Catalan, Ursula; Jose Motilva, Maria; Sola, Rosa; Covas, Maria Isabel; Blanco-Vaca, Francisco; Fito, Montserrat; Mayneris-Perxachs, Jordi;
    Department: Medicina i Cirurgia
    URV's Author/s: Catalán Santos, Úrsula
    Keywords: Selection Risk Promotes Profile Polyphenols enhance Phenolic compounds Metabonomics Hypercholesterolemic subjects. Functional olive oil Endothelial function Cardiovascular-disease Cardiovascular diseases Branched-chain Amino-acids
    Abstract: Phenol-rich foods consumption such as virgin olive oil (VOO) has been shown to have beneficial effects on cardiovascular diseases. The broader biochemical impact of VOO and phenol-enriched OOs remains, however, unclear. A randomized, double-blind, cross-over, controlled trial was performed with thirty-three hypercholesterolemic individuals who ingested for 3-weeks (25 mL/day): (1) an OO enriched with its own olive oil phenolic compounds (PCs) (500 ppm; FOO); (2) an OO enriched with its own olive oil PCs (250 ppm) plus thyme PCs (250 ppm; FOOT); and (3) a VOO with low phenolic content (80 ppm). Serum lipid and glycemic profiles, serum H-1-NMR spectroscopy-based metabolomics, endothelial function, blood pressure, and cardiovascular risk were measured. We combined OPLS-DA with machine learning modelling to identify metabolites discrimination of the treatment groups. Both phenol-enriched OO interventions decreased the levels of glutamine, creatinine, creatine, dimethylamine, and histidine in comparison to VOO one. In addition, FOOT decreased the plasma levels of glycine and DMSO2 compared to VOO, while FOO decreased the circulating alanine concentrations but increased the plasma levels of acetone and 3-HB compared to VOO. Based on these findings, phenol-enriched OOs were shown to result in a favorable shift in the circulating metabolic phenotype, inducing a reduction in metabolites associated with cardiometabolic diseases.
    Thematic Areas: Química Physiology Molecular biology Medicina ii Medicina i Interdisciplinar Food science & technology Food science Farmacia Engenharias ii Clinical biochemistry Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Chemistry, medicinal Cell biology Biotecnología Biodiversidade Biochemistry & molecular biology Biochemistry
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: ursula.catalan@urv.cat
    Author identifier: 0000-0001-8884-9823
    Record's date: 2023-08-05
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.mdpi.com/2076-3921/11/10/1964
    Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Antioxidants. 11 (10):
    APA: Farras, Marta; Swann, Jonathan Richard; Rowland, Ian; Rubio, Laura; Subirana, Isaac; Catalan, Ursula; Jose Motilva, Maria; Sola, Rosa; Covas, Maria Is (2022). Impact of Phenol-Enriched Olive Oils on Serum Metabonome and Its Relationship with Cardiometabolic Parameters: A Randomized, Double-Blind, Cross-Over, Controlled Trial. Antioxidants, 11(10), -. DOI: 10.3390/antiox11101964
    Article's DOI: 10.3390/antiox11101964
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2022
    Publication Type: Journal Publications
  • Keywords:

    Biochemistry,Biochemistry & Molecular Biology,Cell Biology,Chemistry, Medicinal,Clinical Biochemistry,Food Science,Food Science & Technology,Molecular Biology,Physiology
    Selection
    Risk
    Promotes
    Profile
    Polyphenols enhance
    Phenolic compounds
    Metabonomics
    Hypercholesterolemic subjects.
    Functional olive oil
    Endothelial function
    Cardiovascular-disease
    Cardiovascular diseases
    Branched-chain
    Amino-acids
    Química
    Physiology
    Molecular biology
    Medicina ii
    Medicina i
    Interdisciplinar
    Food science & technology
    Food science
    Farmacia
    Engenharias ii
    Clinical biochemistry
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Chemistry, medicinal
    Cell biology
    Biotecnología
    Biodiversidade
    Biochemistry & molecular biology
    Biochemistry
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