Articles producció científica> Química Física i Inorgànica

Structurally Defined Water-Soluble Metallofullerene Derivatives towards Biomedical Applications

  • Identification data

    Identifier: imarina:9286421
  • Authors:

    Li Y
    Biswas R
    Kopcha WP
    Dubroca T
    Abella L
    Sun Y
    Crichton RA
    Rathnam C
    Yang L
    Yeh YW
    Kundu K
    Rodríguez-Fortea A
    Poblet JM
    Lee KB
    Hill S
    Zhang J
    Angewandte Chemie (International Ed. Print)
    10.1002/anie.202211704
    Angewandte Chemie (International Ed. Print). 62 (3): e202211704-
  • Others:

    Author, as appears in the article.: Li Y; Biswas R; Kopcha WP; Dubroca T; Abella L; Sun Y; Crichton RA; Rathnam C; Yang L; Yeh YW; Kundu K; Rodríguez-Fortea A; Poblet JM; Lee KB; Hill S; Zhang J
    Department: Química Física i Inorgànica
    URV's Author/s: Abella Guzman, Laura / Poblet Rius, Josep Maria / Rodríguez Fortea, Antonio
    Keywords: Synthesis design Supramolecular chemistry Rare earth compounds Endohedral metallofullerene Endohedral fullerenes Contrast agents synthesis design supramolecular chemistry scaffolds relaxivity relaxation rare earth compounds hexakis-adducts fullerenes facile preparation endohedral fullerenes cyclooctyne crossover contrast agent
    Abstract: Endohedral metallofullerenes (EMFs) are excellent carriers of rare-earth element (REE) ions in biomedical applications because they preclude the release of toxic metal ions. However, existing approaches to synthesize water-soluble EMF derivatives yield mixtures that inhibit precise drug design. Here we report the synthesis of metallobuckytrio (MBT), a three-buckyball system, as a modular platform to develop structurally defined water-soluble EMF derivatives with ligands by choice. Demonstrated with PEG ligands, the resulting water-soluble MBTs show superb biocompatibility. The Gd MBTs exhibit superior T1 relaxivity than typical Gd complexes, potentially superseding current clinical MRI contrast agents in both safety and efficiency. The Lu MBTs generated reactive oxygen species upon light irradiation, showing promise as photosensitizers. With their modular nature to incorporate other ligands, we anticipate the MBT platform to open new paths towards bio-specific REE drugs.© 2022 Wiley-VCH GmbH.
    Thematic Areas: Química Medicina ii Medicina i Materiais Interdisciplinar General medicine General chemistry Farmacia Engenharias ii Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Chemistry, multidisciplinary Chemistry (miscellaneous) Chemistry (all) Chemistry Catalysis Astronomia / física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: laura.abella@urv.cat josepmaria.poblet@urv.cat antonio.rodriguezf@urv.cat
    Author identifier: 0000-0002-4533-0623 0000-0001-5884-5629
    Record's date: 2024-07-20
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://onlinelibrary.wiley.com/doi/10.1002/anie.202211704
    Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Angewandte Chemie (International Ed. Print). 62 (3): e202211704-
    APA: Li Y; Biswas R; Kopcha WP; Dubroca T; Abella L; Sun Y; Crichton RA; Rathnam C; Yang L; Yeh YW; Kundu K; Rodríguez-Fortea A; Poblet JM; Lee KB; Hill S; (2023). Structurally Defined Water-Soluble Metallofullerene Derivatives towards Biomedical Applications. Angewandte Chemie (International Ed. Print), 62(3), e202211704-. DOI: 10.1002/anie.202211704
    Article's DOI: 10.1002/anie.202211704
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2023
    Publication Type: Journal Publications
  • Keywords:

    Catalysis,Chemistry,Chemistry (Miscellaneous),Chemistry, Multidisciplinary
    Synthesis design
    Supramolecular chemistry
    Rare earth compounds
    Endohedral metallofullerene
    Endohedral fullerenes
    Contrast agents
    synthesis design
    supramolecular chemistry
    scaffolds
    relaxivity
    relaxation
    rare earth compounds
    hexakis-adducts
    fullerenes
    facile preparation
    endohedral fullerenes
    cyclooctyne
    crossover
    contrast agent
    Química
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    General medicine
    General chemistry
    Farmacia
    Engenharias ii
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Chemistry, multidisciplinary
    Chemistry (miscellaneous)
    Chemistry (all)
    Chemistry
    Catalysis
    Astronomia / física
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