Autor según el artículo: Li, Yanbang; Biswas, Rohin; Kopcha, William P; Dubroca, Thierry; Abella, Laura; Sun, Yue; Crichton, Ryan A; Rathnam, Christopher; Yang, Letao; Yeh, Yao-Wen; Kundu, Krishnendu; Rodriguez-Fortea, Antonio; Poblet, Josep M; Lee, Ki-Bum; Hill, Stephen; Zhang, Jianyuan
Departamento: Química Física i Inorgànica
Autor/es de la URV: Abella Guzman, Laura / Poblet Rius, Josep Maria / Rodríguez Fortea, Antonio
Palabras clave: Synthesis design Supramolecular chemistry Rare earth compounds Endohedral metallofullerene Endohedral fullerenes Contrast agents synthesis design supramolecular chemistry scaffolds relaxivity relaxation rare earth compounds hexakis-adducts fullerenes facile preparation endohedral fullerenes cyclooctyne crossover contrast agent
Resumen: Endohedral metallofullerenes (EMFs) are excellent carriers of rare-earth element (REE) ions in biomedical applications because they preclude the release of toxic metal ions. However, existing approaches to synthesize water-soluble EMF derivatives yield mixtures that inhibit precise drug design. Here we report the synthesis of metallobuckytrio (MBT), a three-buckyball system, as a modular platform to develop structurally defined water-soluble EMF derivatives with ligands by choice. Demonstrated with PEG ligands, the resulting water-soluble MBTs show superb biocompatibility. The Gd MBTs exhibit superior T1 relaxivity than typical Gd complexes, potentially superseding current clinical MRI contrast agents in both safety and efficiency. The Lu MBTs generated reactive oxygen species upon light irradiation, showing promise as photosensitizers. With their modular nature to incorporate other ligands, we anticipate the MBT platform to open new paths towards bio-specific REE drugs.© 2022 Wiley-VCH GmbH.
Áreas temáticas: Química Medicina ii Medicina i Materiais Interdisciplinar General medicine General chemistry Farmacia Engenharias ii Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Chemistry, multidisciplinary Chemistry (miscellaneous) Chemistry (all) Chemistry Catalysis Astronomia / física
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: josepmaria.poblet@urv.cat antonio.rodriguezf@urv.cat
Identificador del autor: 0000-0002-4533-0623 0000-0001-5884-5629
Fecha de alta del registro: 2024-10-12
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://onlinelibrary.wiley.com/doi/10.1002/anie.202211704
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Angewandte Chemie (International Ed. Print). 62 (3): e202211704-
Referencia de l'ítem segons les normes APA: Li, Yanbang; Biswas, Rohin; Kopcha, William P; Dubroca, Thierry; Abella, Laura; Sun, Yue; Crichton, Ryan A; Rathnam, Christopher; Yang, Letao; Yeh, Ya (2023). Structurally Defined Water-Soluble Metallofullerene Derivatives towards Biomedical Applications. Angewandte Chemie (International Ed. Print), 62(3), e202211704-. DOI: 10.1002/anie.202211704
DOI del artículo: 10.1002/anie.202211704
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2023
Tipo de publicación: Journal Publications
Repositori URV