Articles producció científica> Medicina i Cirurgia

Utility of ctDNA Liquid Biopsies from Cancer Patients: An Institutional Study of 285 ctDNA Samples

  • Identification data

    Identifier: imarina:9287418
    Authors:
    Gumà JPeña KRiu FGuilarte CHernandez ALucía CMartínez-Madueño FMiranda MJCabezas IGrifoll MPeralta SSerrano SMuñoz FDelamo LRoig BBorràs JBadia JRodriguez-Balada MParada D
    Abstract:
    Liquid biopsy has improved significantly over the last decade and is attracting attention as a tool that can complement tissue biopsy to evaluate the genetic landscape of solid tumors. In the present study, we evaluated the usefulness of liquid biopsy in daily oncology practice in different clinical contexts. We studied ctDNA and tissue biopsy to investigate EGFR, KRAS, NRAS, and BRAF mutations from 199 cancer patients between January 2016 and March 2021. The study included 114 male and 85 female patients with a median age of 68 years. A total of 122 cases were lung carcinoma, 53 were colorectal carcinoma, and 24 were melanoma. Liquid biopsy was positive for a potentially druggable driver mutation in 14 lung and colorectal carcinoma where tissue biopsy was not performed, and in two (3%) lung carcinoma patients whose tissue biopsy was negative. Liquid biopsy identified nine (45%) de novo EGFR-T790M mutations during TKI-treatment follow-up in lung carcinoma. BRAF-V600 mutation resurgence was detected in three (12.5%) melanoma patients during follow-up. Our results confirm the value of liquid biopsy in routine clinical oncologic practice for targeted therapy, diagnosis of resistance to treatment, and cancer follow-up.
  • Others:

    Author, as appears in the article.: Gumà J; Peña K; Riu F; Guilarte C; Hernandez A; Lucía C; Martínez-Madueño F; Miranda MJ; Cabezas I; Grifoll M; Peralta S; Serrano S; Muñoz F; Delamo L; Roig B; Borràs J; Badia J; Rodriguez-Balada M; Parada D
    Department: Medicina i Cirurgia
    URV's Author/s: BORRAS BALADA, JOAN LLUÍS / Gumà Padró, José / Lucia Gozalvez, Clara Beatriz / RODRÍGUEZ BALADA, MARTA
    Keywords: Precision medicine Melanoma Lung Liquid biopsy Ctdna Colorectal Cell lung-cancer Cancer survival ras mutations precision medicine osimertinib melanoma lung ctdna colorectal cancer
    Abstract: Liquid biopsy has improved significantly over the last decade and is attracting attention as a tool that can complement tissue biopsy to evaluate the genetic landscape of solid tumors. In the present study, we evaluated the usefulness of liquid biopsy in daily oncology practice in different clinical contexts. We studied ctDNA and tissue biopsy to investigate EGFR, KRAS, NRAS, and BRAF mutations from 199 cancer patients between January 2016 and March 2021. The study included 114 male and 85 female patients with a median age of 68 years. A total of 122 cases were lung carcinoma, 53 were colorectal carcinoma, and 24 were melanoma. Liquid biopsy was positive for a potentially druggable driver mutation in 14 lung and colorectal carcinoma where tissue biopsy was not performed, and in two (3%) lung carcinoma patients whose tissue biopsy was negative. Liquid biopsy identified nine (45%) de novo EGFR-T790M mutations during TKI-treatment follow-up in lung carcinoma. BRAF-V600 mutation resurgence was detected in three (12.5%) melanoma patients during follow-up. Our results confirm the value of liquid biopsy in routine clinical oncologic practice for targeted therapy, diagnosis of resistance to treatment, and cancer follow-up.
    Thematic Areas: Oncology Medicina iii Cancer research
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: clara.lucia@estudiants.urv.cat jose.guma@urv.cat
    Author identifier: 0000-0001-6965-4529 0000-0001-7541-9832
    Record's date: 2024-09-07
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.mdpi.com/2072-6694/14/23/5859
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Cancers. 14 (23):
    APA: Gumà J; Peña K; Riu F; Guilarte C; Hernandez A; Lucía C; Martínez-Madueño F; Miranda MJ; Cabezas I; Grifoll M; Peralta S; Serrano S; Muñoz F; Delamo L (2022). Utility of ctDNA Liquid Biopsies from Cancer Patients: An Institutional Study of 285 ctDNA Samples. Cancers, 14(23), -. DOI: 10.3390/cancers14235859
    Article's DOI: 10.3390/cancers14235859
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2022
    Publication Type: Journal Publications
  • Keywords:

    Cancer Research,Oncology
    Precision medicine
    Melanoma
    Lung
    Liquid biopsy
    Ctdna
    Colorectal
    Cell lung-cancer
    Cancer
    survival
    ras mutations
    precision medicine
    osimertinib
    melanoma
    lung
    ctdna
    colorectal
    cancer
    Oncology
    Medicina iii
    Cancer research
  • Documents:

  • Cerca a google

    Search to google scholar