Author, as appears in the article.: Gumà J; Peña K; Riu F; Guilarte C; Hernandez A; Lucía C; Martínez-Madueño F; Miranda MJ; Cabezas I; Grifoll M; Peralta S; Serrano S; Muñoz F; Delamo L; Roig B; Borràs J; Badia J; Rodriguez-Balada M; Parada D
Department: Medicina i Cirurgia
URV's Author/s: BORRAS BALADA, JOAN LLUÍS / Gumà Padró, José / Lucia Gozalvez, Clara Beatriz / RODRÍGUEZ BALADA, MARTA
Keywords: Precision medicine Melanoma Lung Liquid biopsy Ctdna Colorectal Cell lung-cancer Cancer survival ras mutations precision medicine osimertinib melanoma lung ctdna colorectal cancer
Abstract: Liquid biopsy has improved significantly over the last decade and is attracting attention as a tool that can complement tissue biopsy to evaluate the genetic landscape of solid tumors. In the present study, we evaluated the usefulness of liquid biopsy in daily oncology practice in different clinical contexts. We studied ctDNA and tissue biopsy to investigate EGFR, KRAS, NRAS, and BRAF mutations from 199 cancer patients between January 2016 and March 2021. The study included 114 male and 85 female patients with a median age of 68 years. A total of 122 cases were lung carcinoma, 53 were colorectal carcinoma, and 24 were melanoma. Liquid biopsy was positive for a potentially druggable driver mutation in 14 lung and colorectal carcinoma where tissue biopsy was not performed, and in two (3%) lung carcinoma patients whose tissue biopsy was negative. Liquid biopsy identified nine (45%) de novo EGFR-T790M mutations during TKI-treatment follow-up in lung carcinoma. BRAF-V600 mutation resurgence was detected in three (12.5%) melanoma patients during follow-up. Our results confirm the value of liquid biopsy in routine clinical oncologic practice for targeted therapy, diagnosis of resistance to treatment, and cancer follow-up.
Thematic Areas: Oncology Medicina iii Cancer research
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: clara.lucia@estudiants.urv.cat jose.guma@urv.cat
Author identifier: 0000-0001-6965-4529 0000-0001-7541-9832
Record's date: 2024-09-07
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.mdpi.com/2072-6694/14/23/5859
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Cancers. 14 (23):
APA: Gumà J; Peña K; Riu F; Guilarte C; Hernandez A; Lucía C; Martínez-Madueño F; Miranda MJ; Cabezas I; Grifoll M; Peralta S; Serrano S; Muñoz F; Delamo L (2022). Utility of ctDNA Liquid Biopsies from Cancer Patients: An Institutional Study of 285 ctDNA Samples. Cancers, 14(23), -. DOI: 10.3390/cancers14235859
Article's DOI: 10.3390/cancers14235859
Entity: Universitat Rovira i Virgili
Journal publication year: 2022
Publication Type: Journal Publications